| Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages. | Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages.
Onyishi CU, Jeon Y, Fejer G, Mukhopadhyay S, Gordon S, May RC. | 10/22/2024 |
| TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain. | TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
Wang L, Yang HY, Zang CX, Shang JM, Liu H, Zhang ZH, Yuan FY, Ju C, Li FY, Bao XQ, Zhang D. | 03/26/2022 |
| MARCO(+) lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination. | MARCO(+) lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination.
Carpentier KS, Sheridan RM, Lucas CJ, Davenport BJ, Li FS, Lucas ED, McCarthy MK, Reynoso GV, May NA, Tamburini BAJ, Hesselberth JR, Hickman HD, Morrison TE., Free PMC Article | 01/8/2022 |
| Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300. | Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300.
Lee KH, Woo J, Kim J, Lee CH, Yoo CG. | 07/3/2021 |
| Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis. | Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
Kanno S, Hirano S, Sakamoto T, Furuyama A, Takase H, Kato H, Fukuta M, Aoki Y., Free PMC Article | 05/1/2021 |
| The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. | The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. | 01/9/2021 |
| Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages. | Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages.
Yamada C, Beron-Pelusso C, Algazzaz N, Heidari A, Luz D, Rawas-Qalaji M, Toderas I, Mascarenhas AK, Kawai T, Movila A., Free PMC Article | 08/29/2020 |
| Clearance from the circulation of chikungunya and o'nyong 'nyong virus was independent of natural antibodies or complement factor C3, and instead relied on scavenger receptor SR-A6 (MARCO). | Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.
Carpentier KS, Davenport BJ, Haist KC, McCarthy MK, May NA, Robison A, Ruckert C, Ebel GD, Morrison TE., Free PMC Article | 03/14/2020 |
| the absence of MARCO does not interfere with the efficiency of HSV-1 entry and that the inhibitory effect on viral adsorption by poly(I), a ligand of MARCO, is independent of MARCO. | Entry of Herpes Simplex Virus 1 into Epidermis and Dermal Fibroblasts Is Independent of the Scavenger Receptor MARCO.
Thier K, Möckel M, Palitzsch K, Döhner K, Sodeik B, Knebel-Mörsdorf D., Free PMC Article | 07/28/2018 |
| presence of MARCO allows rapid Adenovirus (AD) gene expression and strong virus-stimulated innate responses; blockage or lack of MARCO results in strong impairment of these processes;. MARCO is involved in innate Ad recognition and the elevated Ad sensitivity of MARCO-expressing macrophages is due to the expression of this receptor on the cell surface | Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.
Maler MD, Nielsen PJ, Stichling N, Cohen I, Ruzsics Z, Wood C, Engelhard P, Suomalainen M, Gyory I, Huber M, Müller-Quernheim J, Schamel WWA, Gordon S, Jakob T, Martin SF, Jahnen-Dechent W, Greber UF, Freudenberg MA, Fejer G., Free PMC Article | 04/7/2018 |
| Common damage-associated molecular patterns (DAMPs) were internalized through the class A scavenger receptors MSR1 and MARCO in vitro. In ischemic murine brain, DAMP internalization was largely mediated by MSR1. Combined deficiency for Msr1 and Marco in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke. | MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1.
Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A. | 09/2/2017 |
| Increasing MARCO expression by targeting Nrf2 signaling or the Akt-TFEB-MARCO pathway are promising strategies to improve bacterial clearance and survival in postinfluenza bacterial pneumonia. | Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.
Wu M, Gibbons JG, DeLoid GM, Bedugnis AS, Thimmulappa RK, Biswal S, Kobzik L., Free PMC Article | 08/5/2017 |
| free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria. | Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin.
Ordija CM, Chiou TT, Yang Z, Deloid GM, de Oliveira Valdo M, Wang Z, Bedugnis A, Noah TL, Jones S, Koziel H, Kobzik L., Free PMC Article | 08/5/2017 |
| this study shows that Marco functions as co-receptor along with TLRs for HMGB1 in M1-type inflammatory macrophages | Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation.
Komai K, Shichita T, Ito M, Kanamori M, Chikuma S, Yoshimura A. | 05/6/2017 |
| MARCO Is Processed by either Macropinocytosis or Endocytosis-Autophagy Pathway | Macrophage Receptor with Collagenous Structure (MARCO) Is Processed by either Macropinocytosis or Endocytosis-Autophagy Pathway.
Hirano S, Kanno S., Free PMC Article | 06/28/2016 |
| our data demonstrate that MARCO differentially affects TLR-induced DC activation and suggest targeting of MARCO could lead to different outcomes that depend on the inflammatory context encountered by dendritic cells. | The scavenger receptor MARCO modulates TLR-induced responses in dendritic cells.
Kissick HT, Dunn LK, Ghosh S, Nechama M, Kobzik L, Arredouani MS., Free PMC Article | 11/21/2015 |
| Vaccinia virus bound directly to MARCO, and overexpression of MARCO increased susceptibility to vaccinia infection. | Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes.
MacLeod DT, Nakatsuji T, Wang Z, di Nardo A, Gallo RL., Free PMC Article | 02/28/2015 |
| MARCO-/- dendritic cells demonstrated enhanced migratory capacity in response to CCL-21 in vitro. | Examination of MARCO activity on dendritic cell phenotype and function using a gene knockout mouse.
Komine H, Kuhn L, Matsushita N, Mulé JJ, Pilon-Thomas S., Free PMC Article | 02/8/2014 |
| herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease. | HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection.
MacLeod DT, Nakatsuji T, Yamasaki K, Kobzik L, Gallo RL., Free PMC Article | 01/4/2014 |
| results indicate that accumulation of SQSTM1 leads to increased activation of NFE2L2 and the subsequent increase in MARCO and MSR1 | Autophagy regulates phagocytosis by modulating the expression of scavenger receptors.
Bonilla DL, Bhattacharya A, Sha Y, Xu Y, Xiang Q, Kan A, Jagannath C, Komatsu M, Eissa NT., Free PMC Article | 11/23/2013 |
| this study, we confirm that tolerized mouse bone marrow-derived macrophages selectively increase expression of MARCO and increase phagocytosis | Role of macrophage receptor with collagenous structure in innate immune tolerance.
Jing J, Yang IV, Hui L, Patel JA, Evans CM, Prikeris R, Kobzik L, O'Connor BP, Schwartz DA., Free PMC Article | 08/31/2013 |
| MARCO is an important component of anti-Streptococcus pneumoniae responses in murine nasopharyngeal macrophages during bacterial colonization. | MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx.
Dorrington MG, Roche AM, Chauvin SE, Tu Z, Mossman KL, Weiser JN, Bowdish DM., Free PMC Article | 03/16/2013 |
| Fetuin-A-containing calciprotein particles facilitate the clearance of mineral debris by macrophages via SR-A. | Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A.
Herrmann M, Schäfer C, Heiss A, Gräber S, Kinkeldey A, Büscher A, Schmitt MM, Bornemann J, Nimmerjahn F, Herrmann M, Helming L, Gordon S, Jahnen-Dechent W. | 11/3/2012 |
| These results indicate that MARCO suppresses a protective early inflammatory response to influenza, which modulates viral clearance and delays recovery. | MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome.
Ghosh S, Gregory D, Smith A, Kobzik L., Free PMC Article | 12/24/2011 |
| SR-A/MARCO-mediated rapid ligand internalization prevented sensing by surface TLRs while increasing ligand availability in intracellular compartments, thus allowing sensing and robust responses by intracellular sensors. | SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens.
Mukhopadhyay S, Varin A, Chen Y, Liu B, Tryggvason K, Gordon S. | 03/26/2011 |