| Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia. | Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia.
Zhang S, Breidenbach JD, Khalaf FK, Dube PR, Mohammed CJ, Lad A, Stepkowski S, Hinds TD, Kumarasamy S, Kleinhenz A, Tian J, Malhotra D, Kennedy DJ, Cooper CJ, Haller ST., Free PMC Article | 03/13/2021 |
| CD40 was a direct target of miR-16 and was negatively regulated by miR-16 in H9c2 cells stimulated by LPS. The ablation of CD40 aggravated the biological activities of miR-16 in LPS-induced H9c2 cells. | MiR-16, as a potential NF-κB-related miRNA, exerts anti-inflammatory effects on LPS-induced myocarditis via mediating CD40 expression: A preliminary study.
Li QQ, Xi J, Li BQ, Li N. | 02/29/2020 |
| Transient middle cerebral artery occlusion (MCAO) rats yielded an acceleration of thrombus formation that was accompanied by increased CD40 levels in serum. The brain infarction was significantly decreased in CD40 antagonist treatment group compared to MCAO model group. The mTOR/S6K signaling was activated in MACO model than that of CD40 antagonist treatment group. | The CD40/CD40L system regulates rat cerebral microvasculature after focal ischemia/reperfusion via the mTOR/S6K signaling pathway.
Jiang RH, Xu XQ, Wu CJ, Lu SS, Zu QQ, Zhao LB, Liu S, Shi HB. | 11/10/2018 |
| Cd40 plays a crucial role in the development of hypertensive renal disease via development of renal fibrosis. | Targeted disruption of Cd40 in a genetically hypertensive rat model attenuates renal fibrosis and proteinuria, independent of blood pressure.
Haller ST, Kumarasamy S, Folt DA, Wuescher LM, Stepkowski S, Karamchandani M, Waghulde H, Mell B, Chaudhry M, Maxwell K, Upadhyaya S, Drummond CA, Tian J, Filipiak WE, Saunders TL, Shapiro JI, Joe B, Cooper CJ., Free PMC Article | 11/4/2017 |
| SIRT1 inhibits LPS-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-kappaB signaling pathway | SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-κB signaling pathway.
Lin QQ, Geng YW, Jiang ZW, Tian ZJ. | 03/4/2017 |
| Suggest that CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury. | CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury.
de Ramon L, Ripoll E, Merino A, Lúcia M, Aran JM, Pérez-Rentero S, Lloberas N, Cruzado JM, Grinyó JM, Torras J., Free PMC Article | 06/11/2016 |
| Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents | Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents.
Durand J, Huchet V, Merieau E, Usal C, Chesneau M, Remy S, Heslan M, Anegon I, Cuturi MC, Brouard S, Chiffoleau E. | 02/27/2016 |
| Migrating lymph dendritic cells contain stores of CD40 that can be mobilized rapidly to sites of interaction with antigen-specific T cells; the disappearance of CD40 by 24 hours may help regulate T cell activation. | Migrating lymph dendritic cells contain intracellular CD40 that is mobilized to the immunological synapse during interactions with antigen-specific T lymphocytes.
Foster N, Turnbull EL, Macpherson G. | 02/23/2013 |
| CD40/CD40L and IkappaB/NF-kappaB pathways could effectively extend the survival of islet grafts | Simultaneous blockade of the CD40/CD40L and NF-κB pathways prolonged islet allograft survival.
Wang XH, Ding XM, Li Y, Liu HB, Xue WJ, Tian XH, Feng XS, Jiao FM, Zheng J. | 04/21/2012 |
| The intra-renal effective blockade of the CD40/CD40L signal reduces graft inflammation as well as the incidence of humoral vascular acute rejection in transplanted kidneys. | In vivo therapeutic efficacy of intra-renal CD40 silencing in a model of humoral acute rejection.
Ripoll E, Pluvinet R, Torras J, Olivar R, Vidal A, Franquesa M, Cassis L, Cruzado JM, Bestard O, Grinyó JM, Aran JM, Herrero-Fresneda I. | 02/4/2012 |
| Data suggest that astrocytes activated by CD40-CD40L in co-culture induce inflammatory cytokine production, and secreted cytokines re-activate astrocytes via Jak/STAT1701 pathways, and release more cytokines that contribute to the development of EAE. | Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L.
Kim DY, Hong GU, Ro JY., Free PMC Article | 06/4/2011 |
| mRNAs and proteins for inducible nitric oxide synthase and tumor necrosis factor-alpha are more easily induced in CD40-expressing microglia than CD40-negative microglia, after lipopolysaccharide stimulation. | Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40+ microglia by comparison to CD40- microglia.
Kawahara K, Yoshida A, Koga K, Yokoo S, Kuniyasu A, Gotoh T, Sawada M, Nakayama H. | 01/21/2010 |
| expression and function on neuronal cells | CD40 is expressed and functional on neuronal cells.
Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M., Free PMC Article | 01/21/2010 |
| CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1. | CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1.
Mann J, Oakley F, Johnson PW, Mann DA. | 01/21/2010 |
| B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis of Lewis rats | B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis in Lewis rats.
Zhu W, Mix E, Jin T, Adem A, Zhu J. | 01/21/2010 |