| Calcium-Dependent Regulation of the Neuronal Glycine Transporter GlyT2 by M2 Muscarinic Acetylcholine Receptors. | Calcium-Dependent Regulation of the Neuronal Glycine Transporter GlyT2 by M2 Muscarinic Acetylcholine Receptors.
Jiménez E, Fornés A, Felipe R, Núñez E, Aragón C, López-Corcuera B. | 07/2/2022 |
| The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo. | The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.
de la Rocha-Muñoz A, Núñez E, Vishwanath AA, Gómez-López S, Dhanasobhon D, Rebola N, López-Corcuera B, de Juan-Sanz J, Aragón C., Free PMC Article | 12/25/2021 |
| Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia. | Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia.
de la Rocha-Muñoz A, Melgarejo E, Aragón C, López-Corcuera B. | 12/11/2021 |
| Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain. | Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain.
Imam MZ, Kuo A, Nicholson JR, Corradini L, Smith MT. | 07/3/2021 |
| Phosphorylation of Serine 157 Protects the Rat Glycine Transporter GlyT2 from Calpain Cleavage. | Phosphorylation of Serine 157 Protects the Rat Glycine Transporter GlyT2 from Calpain Cleavage.
Baliova M, Jursky F. | 05/29/2021 |
| E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2. | E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2.
de la Rocha-Muñoz A, Núñez E, Arribas-González E, López-Corcuera B, Aragón C, de Juan-Sanz J., Free PMC Article | 12/5/2020 |
| Following spinal cord transection there is a decrease in GlyT2 mRNA and GlyT2 protein expression. | Time-dependent, bidirectional, anti- and pro-spinal hyper-reflexia and muscle spasticity effect after chronic spinal glycine transporter 2 (GlyT2) oligonucleotide-induced downregulation.
Kamizato K, Marsala S, Navarro M, Kakinohana M, Platoshyn O, Yoshizumi T, Lukacova N, Wancewicz E, Powers B, Mazur C, Marsala M. | 01/12/2019 |
| Results show that glycine transport by neuronal glycine transporter GlyT2 responds positively to treatments promoting pain signaling including ATP. GlyT2 is up-regulated upon stimulation of ATP-preferring P2X2/3 receptors in brainstem/spinal cord primary neuronal cultures in a paracrine manner causing a rapid increase of surface transporter and glycine transport. | P2X receptors up-regulate the cell-surface expression of the neuronal glycine transporter GlyT2.
Villarejo-López L, Jiménez E, Bartolomé-Martín D, Zafra F, Lapunzina P, Aragón C, López-Corcuera B. | 06/16/2018 |
| Study showed that glycine uptake mediated by GlyT1 and GlyT2 in astrocytes is modulated by BDNF | BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in astrocytes.
Aroeira RI, Sebastião AM, Valente CA. | 07/30/2016 |
| GlyT2 activity is pre-synaptically controlled by physical and functional association with plasma membrane PMCA2, PMCA3, and NCX1. | Presynaptic control of glycine transporter 2 (GlyT2) by physical and functional association with plasma membrane Ca2+-ATPase (PMCA) and Na+-Ca2+ exchanger (NCX).
de Juan-Sanz J, Núñez E, Zafra F, Berrocal M, Corbacho I, Ibáñez I, Arribas-González E, Marcos D, López-Corcuera B, Mata AM, Aragón C., Free PMC Article | 03/7/2015 |
| astrocytes express functional GlyT2, which challenge previous findings that those cells would express only GlyT1 | GlyT1 and GlyT2 in brain astrocytes: expression, distribution and function.
Aroeira RI, Sebastião AM, Valente CA. | 02/7/2015 |
| Calnexin discriminates between different conformational states of GlyT2 displaying a lectin-independent chaperone activity. | Calnexin-assisted biogenesis of the neuronal glycine transporter 2 (GlyT2).
Arribas-González E, Alonso-Torres P, Aragón C, López-Corcuera B., Free PMC Article | 11/30/2013 |
| The clathrin-mediated pathway is the primary mechanism for constitutive and regulated GLYT2 endocytosis in heterologous cells and neurons. | Endocytosis of the neuronal glycine transporter GLYT2: role of membrane rafts and protein kinase C-dependent ubiquitination.
de Juan-Sanz J, Zafra F, López-Corcuera B, Aragón C. | 06/9/2012 |
| Using molecular interaction potential maps and mutagenesis, identified a conserved region in the GLYT2 external vestibule likely to be involved in Na+ interactions. Replacement of Asp471 reduced Na+ affinity and Na+ co-operativity of transport. | An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling.
Pérez-Siles G, Núñez E, Morreale A, Jiménez E, Leo-Macías A, Pita G, Cherubino F, Sangaletti R, Bossi E, Ortíz AR, Aragón C, López-Corcuera B. | 04/14/2012 |
| In contrast to GLYT1, high and low affinity lithium-binding processes are detected in GLYT2. | Molecular basis of the differential interaction with lithium of glycine transporters GLYT1 and GLYT2.
Pérez-Siles G, Morreale A, Leo-Macías A, Pita G, Ortíz AR, Aragón C, López-Corcuera B. | 09/3/2011 |
| Both extracellular glycine and GlyT-2 are essential for forskolin-induced increase in amplitude of glycinergic miniature inhibitory postsynaptic currents during postnatal development. | GlyT-2 mediates the forskolin-induced increase of glycinergic transmission.
Nakamura M, Jang IS. | 06/4/2011 |
| GLYT2 is associated with membrane rafts in the plasma membrane of brainstem terminals and neurons and is functionally modulated by the lipid environment. | The neuronal glycine transporter GLYT2 associates with membrane rafts: functional modulation by lipid environment.
Núñez E, Alonso-Torres P, Fornés A, Aragón C, López-Corcuera B. | 08/16/2010 |
| Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. | Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.
Edington AR, McKinzie AA, Reynolds AJ, Kassiou M, Ryan RM, Vandenberg RJ., Free PMC Article | 01/21/2010 |
| study investigated the subcellular distribution of GLYT2 in brainstem tissue; data suggest that intracellular GLYT2 resides in a subset of endosomal membranes and may traffic around several compartments, mainly Rab11-positive endosomes | Subcellular localization of the neuronal glycine transporter GLYT2 in brainstem.
Núñez E, Pérez-Siles G, Rodenstein L, Alonso-Torres P, Zafra F, Jiménez E, Aragón C, López-Corcuera B. | 01/21/2010 |
| Data show the retina 2 expression of glycine transporter 1 in rats. | Glycine transporters (glycine transporter 1 and glycine transporter 2) are expressed in retina.
Peña-Rangel MT, Riesgo-Escovar JR, Sánchez-Chávez G, Salceda R. | 01/21/2010 |
| Syntenin-1 may be an in vivo binding partner of GlyT2 that regulates its trafficking and/or presynaptic localization in glycinergic neurons. | The neuronal glycine transporter 2 interacts with the PDZ domain protein syntenin-1.
Ohno K, Koroll M, El Far O, Scholze P, Gomeza J, Betz H. | 01/21/2010 |
| Many areas of the brainstem and cerebellum involve double-labeled neurons with GLYT2 and GAD67 mRNAs and suggests that the corelease of glycine and GABA from single neurons is more widespread than has been reported. | Overall distribution of GLYT2 mRNA-containing versus GAD67 mRNA-containing neurons and colocalization of both mRNAs in midbrain, pons, and cerebellum in rats.
Tanaka I, Ezure K. | 01/21/2010 |
| residue Lys-422 is crucial for glycine transport | The second intracellular loop of the glycine transporter 2 contains crucial residues for glycine transport and phorbol ester-induced regulation.
Fornés A, Núñez E, Aragón C, López-Corcuera B. | 01/21/2010 |
| Activation of a Ca2+-dependent protease, likely calpain, in spinal cord synaptosomes or cultured spinal cord neurons, results in partial proteolysis; this may contribute to regulation of GlyT2 trafficking and/or function in the neuronal plasma membrane | Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2.
Baliova M, Betz H, Jursky F. | 01/21/2010 |
| No significant change in either VGLUT1 or GlyT2 labeling of sacrocaudal motoneurons at any of the time points examined. | VGLUT1 and GLYT2 labeling of sacrocaudal motoneurons in the spinal cord injured spastic rat.
Kitzman P. | 01/21/2010 |