| Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis. | Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis.
Donovan ML, Bielefeldt-Ohmann H, Rollo RF, McPherson SJ, Schultz TE, Mori G, Kling JC, Blumenthal A. | 04/20/2023 |
| RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-kappaB signaling pathways. | RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-κB signaling pathways.
Zhu J, Zhang Y, Shi L, Xia Y, Zha H, Li H, Song Z. | 06/25/2022 |
| Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs. | Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs.
Roe K, Shu GL, Draves KE, Giordano D, Pepper M, Clark EA., Free PMC Article | 05/23/2020 |
| A critical role of CD180 in regulating TLR7- and TLR9-mediated activation of macrophages and DCs. | CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus.
Yang Y, Wang C, Cheng P, Zhang X, Li X, Hu Y, Xu F, Hong F, Dong G, Xiong H., Free PMC Article | 10/5/2019 |
| the impaired venous OR in RP105(-/-) mice could result from of a shift in both macrophages and VSMCs towards a regenerative phenotype, identifying a novel relationship between inflammation and VSMC function in AVF maturation. | Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure.
Bezhaeva T, Wong C, de Vries MR, van der Veer EP, van Alem CMA, Que I, Lalai RA, van Zonneveld AJ, Rotmans JI, Quax PHA., Free PMC Article | 05/11/2019 |
| The present study shows that a noncanonical Toll-like receptor complex, CD180/MD-1, is specifically expressed on Multiple myeloma cells and senses bacterial lipopolysaccharide to transduce proliferative signals, leading to the regrowth of dormant Multiple myeloma clones. | Myeloma Cells Are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex, Which Senses Lipopolysaccharide.
Kikuchi J, Kuroda Y, Koyama D, Osada N, Izumi T, Yasui H, Kawase T, Ichinohe T, Furukawa Y. | 03/23/2019 |
| Silencing Cd180 results in increased phagocytosis while tempering the production of the proinflammatory cytokine TNF during Borrelia burgdorferi infection. | A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi.
Carreras-González A, Navasa N, Martín-Ruiz I, Lavín JL, Azkargorta M, Atondo E, Barriales D, Macías-Cámara N, Pascual-Itoiz MA, Sampedro L, Tomás-Cortázar J, Peña-Cearra A, Pellón A, Prados-Rosales R, Abecia L, Elortza F, Aransay AM, Rodríguez H, Anguita J., Free PMC Article | 08/25/2018 |
| the close association between the increased proportion of CD180-negative B cells and the activation of IFN-alpha signaling in Systemic lupus erythematosus, is reported. | Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.
You M, Dong G, Li F, Ma F, Ren J, Xu Y, Yue H, Tang R, Ren D, Hou Y., Free PMC Article | 07/15/2017 |
| Data show that RP105 knockout (-/-) smooth muscle cells and mast cells secreted higher levels of chemokine (C-C motif) ligand 2 protein (CCL2). | Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.
Wezel A, de Vries MR, Maassen JM, Kip P, Peters EA, Karper JC, Kuiper J, Bot I, Quax PHA., Free PMC Article | 03/11/2017 |
| These data unveil a novel innate immune signaling axis that orchestrates key cytokine responses of macrophages and provide molecular insight into the functions of RP105 as an innate immune receptor for mycobacteria. | RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection.
Yu CH, Micaroni M, Puyskens A, Schultz TE, Yeo JC, Stanley AC, Lucas M, Kurihara J, Dobos KM, Stow JL, Blumenthal A. | 01/2/2016 |
| RP105 regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model. | TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model.
Bastiaansen AJ, Karper JC, Wezel A, de Boer HC, Welten SM, de Jong RC, Peters EA, de Vries MR, van Oeveren-Rietdijk AM, van Zonneveld AJ, Hamming JF, Nossent AY, Quax PH., Free PMC Article | 10/24/2015 |
| RP105 deficiency results in reduced early atherosclerotic plaque development with a marked decrease in lesional macrophage content, which may be due to disturbed migration of RP105 deficient monocytes resulting from CCR2 downregulation | RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner.
Wezel A, van der Velden D, Maassen JM, Lagraauw HM, de Vries MR, Karper JC, Kuiper J, Bot I, Quax PH. | 10/24/2015 |
| Deficiency of the endogenous TLR4 inhibitor, RP105, leads to pronounced cardiac dilation after myocardial infarction. | RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice.
Louwe MC, Karper JC, de Vries MR, Nossent AY, Bastiaansen AJ, van der Hoorn JW, Willems van Dijk K, Rensen PC, Steendijk P, Smit JW, Quax PH. | 07/25/2015 |
| Data indicate that RP105 and TLR4 are both expressed by vascular smooth muscle cells (VSMC). | TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation.
Karper JC, Ewing MM, de Vries MR, de Jager SC, Peters EA, de Boer HC, van Zonneveld AJ, Kuiper J, Huizinga EG, Brondijk TH, Jukema JW, Quax PH., Free PMC Article | 02/8/2014 |
| RP105 deficiency on circulating cells results in an intriguing unexpected TLR-associated mechanisms that decrease atherosclerotic lesion formation with alterations on proinflammatory B2 B cells. | An unexpected intriguing effect of Toll-like receptor regulator RP105 (CD180) on atherosclerosis formation with alterations on B-cell activation.
Karper JC, de Jager SC, Ewing MM, de Vries MR, Bot I, van Santbrink PJ, Redeker A, Mallat Z, Binder CJ, Arens R, Jukema JW, Kuiper J, Quax PH. | 01/11/2014 |
| The function of TLR2 and TLR4 in response to TLR ligands could be associated with each other by RP105. | RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling.
Liu B, Zhang N, Liu Z, Fu Y, Feng S, Wang S, Cao Y, Li D, Liang D, Li F, Song X, Yang Z. | 11/16/2013 |
| Data show that both RP105/MD-1 and TLR4/MD-2 are expressed in marginal zone (MZ) B cells. | The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.
Nagai Y, Yanagibashi T, Watanabe Y, Ikutani M, Kariyone A, Ohta S, Hirai Y, Kimoto M, Miyake K, Takatsu K. | 10/6/2012 |
| The RP105/MD-1 complex is a major mediator of adipose tissue inflammation independent of TLR4 signaling and may represent a novel therapeutic target for obesity-associated metabolic disorders. | The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama HO, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y., Free PMC Article | 06/30/2012 |
| Modulation of B cell proliferation by RP105 is not a function of B cell-intrinsic expression of RP105. | Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
Allen JL, Flick LM, Divanovic S, Jackson SW, Bram R, Rawlings DJ, Finkelman FD, Karp CL., Free PMC Article | 06/2/2012 |
| Both mouse and human RP105/MD-1 exhibit dimerization of the 1:1 RP105/MD-1 complex, demonstrating a novel organization. | Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.
Ohto U, Miyake K, Shimizu T. | 12/17/2011 |
| CD180 stimulation induces intrinsic B cell proliferation and differentiation | Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway.
Chaplin JW, Kasahara S, Clark EA, Ledbetter JA., Free PMC Article | 11/19/2011 |
| RP105 regulates the antigen-presenting cell function and Treg development, which induced the attenuation of the cell-mediated immune responses and, as a result, suppressed the development of collagen-induced arthritis . | Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis.
Tada Y, Koarada S, Morito F, Mitamura M, Inoue H, Suematsu R, Ohta A, Miyake K, Nagasawa K., Free PMC Article | 01/21/2010 |
| The data identify RP105 as an accessory molecule for TLR2, forming part of the receptor complex for innate immune recognition of mycobacterial lipoproteins. | RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins.
Blumenthal A, Kobayashi T, Pierini LM, Banaei N, Ernst JD, Miyake K, Ehrt S., Free PMC Article | 01/21/2010 |
| RP105 regulated TLR4 signaling in dendritic cells | Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, Visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y, Kurt-Jones EA, Karp CL., Free PMC Article | 01/21/2010 |
| A signal via RP105 is uniquely important for regulating Toll-like receptor-dependent antibody production to microbial membranes. | The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.
Nagai Y, Kobayashi T, Motoi Y, Ishiguro K, Akashi S, Saitoh S, Kusumoto Y, Kaisho T, Akira S, Matsumoto M, Takatsu K, Miyake K. | 01/21/2010 |