| Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors. | Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors.
Shay TF, Sullivan EE, Ding X, Chen X, Ravindra Kumar S, Goertsen D, Brown D, Crosby A, Vielmetter J, Borsos M, Wolfe DA, Lam AW, Gradinaru V., Free PMC Article | 04/21/2023 |
| Ly6c as a New Marker of Mouse Blood Vessels: Qualitative and Quantitative Analyses on Intact and Ischemic Retinas. | Ly6c as a New Marker of Mouse Blood Vessels: Qualitative and Quantitative Analyses on Intact and Ischemic Retinas.
Martínez-Carmona M, Lucas-Ruiz F, Gallego-Ortega A, Galindo-Romero C, Norte-Muñoz M, González-Riquelme MJ, Valiente-Soriano FJ, Vidal-Sanz M, Agudo-Barriuso M., Free PMC Article | 02/5/2022 |
| Infection-induced type I interferons critically modulate the homeostasis and function of CD8(+) naive T cells. | Infection-induced type I interferons critically modulate the homeostasis and function of CD8(+) naïve T cells.
Jergović M, Coplen CP, Uhrlaub JL, Besselsen DG, Cheng S, Smithey MJ, Nikolich-Žugich J., Free PMC Article | 10/9/2021 |
| Ly6CLo Monocyte/Macrophages are Essential for Thrombus Resolution in a Murine Model of Venous Thrombosis. | Ly6CLo Monocyte/Macrophages are Essential for Thrombus Resolution in a Murine Model of Venous Thrombosis.
Kimball AS, Obi AT, Luke CE, Dowling AR, Cai Q, Adili R, Jankowski H, Schaller M, Holinstadt M, Jaffer FA, Kunkel SL, Gallagher KA, Henke PK., Free PMC Article | 12/12/2020 |
| Ly6c(Lo) non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. | Ly6c(Lo) non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A., Free PMC Article | 11/28/2020 |
| Splenic Ly6Chi monocytes are critical players in dystrophic muscle injury and repair. | Splenic Ly6Chi monocytes are critical players in dystrophic muscle injury and repair.
Rizzo G, Di Maggio R, Benedetti A, Morroni J, Bouche M, Lozanoska-Ochser B., Free PMC Article | 11/21/2020 |
| The Ym1(+)Ly6C(hi) monocytes greatly expanded in bone marrow during the recovery phase of systemic inflammation or tissue injury. | Emergence of immunoregulatory Ym1(+)Ly6C(hi) monocytes during recovery phase of tissue injury.
Ikeda N, Asano K, Kikuchi K, Uchida Y, Ikegami H, Takagi R, Yotsumoto S, Shibuya T, Makino-Okamura C, Fukuyama H, Watanabe T, Ohmuraya M, Araki K, Nishitai G, Tanaka M. | 09/28/2019 |
| TCR-dependent and cytokine-mediated signals that modulate T cell expression of Ly6C and Sca-1 in vitro and in vivo during infection. | Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1.
DeLong JH, Hall AO, Konradt C, Coppock GM, Park J, Harms Pritchard G, Hunter CA., Free PMC Article | 02/16/2019 |
| Splenic Ly6C(hi) monocytes contribute to adverse late post-ischemic left ventricular remodeling in heme oxygenase-1 deficient mice. | Splenic Ly6C(hi) monocytes contribute to adverse late post-ischemic left ventricular remodeling in heme oxygenase-1 deficient mice.
Tomczyk M, Kraszewska I, Szade K, Bukowska-Strakova K, Meloni M, Jozkowicz A, Dulak J, Jazwa A., Free PMC Article | 04/14/2018 |
| CX3CL1 is upregulated in both human and murine tumors following VEGF signaling blockade, resulting in recruitment of CX3CR1+Ly6Clo monocytes into the tumor | Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D., Free PMC Article | 10/14/2017 |
| surface expression on Ly6C(high) monocytes changes in a time-of-day-dependent manner, which crucially affects cardiac monocyte recruitment after an acute ischemic event. | Ly6C(high) Monocytes Oscillate in the Heart During Homeostasis and After Myocardial Infarction-Brief Report.
Schloss MJ, Hilby M, Nitz K, Guillamat Prats R, Ferraro B, Leoni G, Soehnlein O, Kessler T, He W, Luckow B, Horckmans M, Weber C, Duchene J, Steffens S. | 09/9/2017 |
| monocyte differentiation occurred through de novo enhancer establishment and activation of pre-established (poised) enhancers. Generation of Ly6C(-) monocytes involved induction of the transcription factor C/EBPbeta and C/EBPbeta-deficient mice lacked Ly6C(-) monocytes. | Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C(-) Cells.
Mildner A, Schönheit J, Giladi A, David E, Lara-Astiaso D, Lorenzo-Vivas E, Paul F, Chappell-Maor L, Priller J, Leutz A, Amit I, Jung S. | 09/9/2017 |
| Ly6C, 4-1BB, and KLRG1 have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease | Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice.
Montufar-Solis D, Williams A, Vigneswaran N, Klein JR., Free PMC Article | 06/10/2017 |
| The adapter Mal (encoded by TIRAP) has appeared crucial for the cytokine production by Ly6C(lo) but not by Ly6C(hi) monocytes. The protein Mal was necessary to induce cytokine synthesis by Ly6C(lo) monocytes after triggering TLR2 or TLR9. | MyD88 Adapter-like (Mal)/TIRAP Is Required for Cytokine Production by Splenic Ly6CloTLR2hi but Not by Ly6ChiTLR2hi Monocytes during Trypanosoma cruzi Infection.
Gravina HD, Goes AM, Murta SM, Ropert C., Free PMC Article | 06/3/2017 |
| data demonstrate that CD11c(hi) DCs provide a critical and unexpected role to preserve the immune-privileged CNS in lethal neuroinflammation via regulating the differentiation, function, and trafficking of CD11b(+)Ly-6C(hi) monocytes. | CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation.
Kim JH, Choi JY, Kim SB, Uyangaa E, Patil AM, Han YW, Park SY, Lee JH, Kim K, Eo SK., Free PMC Article | 10/1/2016 |
| Data show that Ly6C(high) monocyte subset after middle cerebral artery occlusion/reperfusion (MCAO/R) peaked on day 2 after the operation and was correlated with cerebral infarct size. | [Increased circulating Ly6Chigh monocyte subsets are correlated with cerebral infarct size in cerebral ischemia/reperfusion mouse models].
Zhang X, Li H, Li Y, Ma Y, Luo Y, Ji W, Zhou X, Li Y. | 07/30/2016 |
| Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection. | Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection.
Peters NC, Pagán AJ, Lawyer PG, Hand TW, Henrique Roma E, Stamper LW, Romano A, Sacks DL., Free PMC Article | 11/7/2015 |
| in vitro, Ly6C(high) NK cells become Ly6C(low) NK cells with strong effector functions upon stimulation with IL-15. | Mature resting Ly6C(high) natural killer cells can be reactivated by IL-15.
Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A. | 11/22/2014 |
| Monocytes expressing Ly-6C orchestrate both inflammatory and reparative phases during myocardial infarction. | Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium.
Hilgendorf I, Gerhardt LM, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK., Free PMC Article | 06/21/2014 |
| MPYS-deficient Ly6C(hi) monocytes are intrinsically defective in migration to the liver, but not the spleen. | STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration.
Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC., Free PMC Article | 05/18/2013 |
| Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. | Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.
Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, Hartland SN, Snowdon VK, Cappon A, Gordon-Walker TT, Williams MJ, Dunbar DR, Manning JR, van Rooijen N, Fallowfield JA, Forbes SJ, Iredale JP., Free PMC Article | 02/2/2013 |
| Identify for the involvement of inflammatory Ly-6C(hi) monocytes in the pathogenesis of transplant arteriosclerosis, particularly in conditions of hyperlipidemia. | Inflammatory Ly-6C(hi) monocytes play an important role in the development of severe transplant arteriosclerosis in hyperlipidemic recipients.
Schiopu A, Nadig SN, Cotoi OS, Hester J, van Rooijen N, Wood KJ., Free PMC Article | 01/5/2013 |
| decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection | Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection.
Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM., Free PMC Article | 12/24/2011 |
| TNF-alpha-dependent regulation of acute pancreatitis severity by Ly-6C(hi) monocytes in mice. | TNF-alpha-dependent regulation of acute pancreatitis severity by Ly-6C(hi) monocytes in mice.
Perides G, Weiss ER, Michael ES, Laukkarinen JM, Duffield JS, Steer ML., Free PMC Article | 07/2/2011 |
| Ly6C(high-expressing) and Ly6C(low-expressing) bone marrow (BM)-derived monocytes have different fates, demonstrating that BM may be a reservoir of preinflammatory monocytes for rapid deployment as inflammatory dendritic cells during virus infection. | Accelerated dendritic cell differentiation from migrating Ly6C(lo) bone marrow monocytes in early dermal West Nile virus infection.
Davison AM, King NJ. | 04/30/2011 |