| The CEBPA-FGF21 regulatory network may participate in the T2DM-induced skeletal muscle atrophy by regulating the autophagy-lysosomal pathway. | The CEBPA-FGF21 regulatory network may participate in the T2DM-induced skeletal muscle atrophy by regulating the autophagy-lysosomal pathway.
Wu K, Huang S, Zheng F, Liu Y. | 09/28/2023 |
| Endogenous FGF21 attenuates blood-brain barrier disruption in penumbra after delayed recanalization in MCAO rats through FGFR1/PI3K/Akt pathway. | Endogenous FGF21 attenuates blood-brain barrier disruption in penumbra after delayed recanalization in MCAO rats through FGFR1/PI3K/Akt pathway.
Zheng W, Li W, Zeng Y, Yuan H, Yang H, Chen R, Zhu A, Wu J, Song Z, Yan W., Free PMC Article | 08/7/2023 |
| Exploring the Epigenetic Regulated Modulation of Fibroblast Growth Factor 21 Involvement in High-Fat Diet Associated Parkinson's Disease in Rats. | Exploring the Epigenetic Regulated Modulation of Fibroblast Growth Factor 21 Involvement in High-Fat Diet Associated Parkinson's Disease in Rats.
Kakoty V, Kc S, Yang CH, Dubey SK, Taliyan R. | 02/23/2023 |
| Lysine or Threonine Deficiency Decreases Body Weight Gain in Growing Rats despite an Increase in Food Intake without Increasing Energy Expenditure in Response to FGF21. | Lysine or Threonine Deficiency Decreases Body Weight Gain in Growing Rats despite an Increase in Food Intake without Increasing Energy Expenditure in Response to FGF21.
Moro J, Roisné-Hamelin G, Chaumontet C, Even PC, Blais A, Cansell C, Piedcoq J, Gaudichon C, Tomé D, Azzout-Marniche D., Free PMC Article | 01/21/2023 |
| The Association Between FGF21 and Diabetic Erectile Dysfunction: Evidence from Clinical and Animal Studies. | The Association Between FGF21 and Diabetic Erectile Dysfunction: Evidence from Clinical and Animal Studies.
Yang S, Zhang Y, Lyu X, Gu Y, Zhang G, Liu P, Zheng Y, Guo Z, Zhang Y, Hou H., Free PMC Article | 10/15/2022 |
| Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21. | Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21.
Pena-Leon V, Folgueira C, Barja-Fernández S, Pérez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, González-Saenz P, Vázquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, López M, Tovar S, Casanueva FF, Valjent E, Diéguez C, Prevot V, Nogueiras R, Seoane LM., Free PMC Article | 07/30/2022 |
| Possible effects of fibroblast growth factor 21 on vascular calcification via suppressing activating transcription factor 4 mediated apoptosis and osteogenic transformation in rats. | Possible effects of fibroblast growth factor 21 on vascular calcification via suppressing activating transcription factor 4 mediated apoptosis and osteogenic transformation in rats.
Shi Y, Zheng Z, Luo J, Li Y, He S, Shen X, Liu J. | 06/18/2022 |
| [Effects of different exercise on liver lipid accumulation and FGF21 secretion in obese rats]. | [Effects of different exercise on liver lipid accumulation and FGF21 secretion in obese rats].
Zhang Y, Sheng L, Liu XW, Wei J, Liu XJ, Zhang NY, Wang ZY. | 06/11/2022 |
| Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart. | Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart.
Kawakami R, Sunaga H, Iso T, Kaneko R, Koitabashi N, Obokata M, Harada T, Matsui H, Yokoyama T, Kurabayashi M., Free PMC Article | 05/14/2022 |
| Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2. | Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2.
Moon H, Choi JW, Song BW, Kim IK, Lim S, Lee S, Han G, Hwang KC, Kim SW., Free PMC Article | 04/16/2022 |
| Rats Self-Select a Constant Protein-to-Carbohydrate Ratio Rather Than a Constant Protein-to-Energy Ratio and Have Low Plasma FGF21 Concentrations. | Rats Self-Select a Constant Protein-to-Carbohydrate Ratio Rather Than a Constant Protein-to-Energy Ratio and Have Low Plasma FGF21 Concentrations.
Gehring J, Azzout-Marniche D, Chaumontet C, Piedcoq J, Gaudichon C, Even PC. | 02/5/2022 |
| Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21-ACE2 signaling. | Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21-ACE2 signaling.
Song JJ, Yang M, Liu Y, Song JW, Liu XY, Miao R, Zhang ZZ, Liu Y, Fan YF, Zhang Q, Dong Y, Yang XC, Zhong JC., Free PMC Article | 01/29/2022 |
| Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide. | Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide.
Babaei M, Alizadeh-Fanalou S, Nourian A, Yarahmadi S, Farahmandian N, Nabi-Afjadi M, Alipourfard I, Bahreini E., Free PMC Article | 12/11/2021 |
| Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats. | Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats.
Moro J, Chaumontet C, Even PC, Blais A, Piedcoq J, Gaudichon C, Tomé D, Azzout-Marniche D., Free PMC Article | 11/6/2021 |
| FGF21 impedes peripheral myelin development by stimulating p38 MAPK/c-Jun axis. | FGF21 impedes peripheral myelin development by stimulating p38 MAPK/c-Jun axis.
Zhang Y, Jiang K, Xie G, Ding J, Peng S, Liu X, Sun C, Tang X. | 09/11/2021 |
| FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival. | FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
Zhou K, Chen H, Lin J, Xu H, Wu H, Bao G, Li J, Deng X, Shui X, Gao W, Ding J, Xiao J, Xu H., Free PMC Article | 09/26/2020 |
| suggest that FGF21 signaling contributes to the caloric restriction-induced metabolic remodeling of white adipose tissue | Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.
Fujii N, Uta S, Kobayashi M, Sato T, Okita N, Higami Y. | 06/20/2020 |
| Cold acclimation significantly reduced circulating FGF21 and its liver expression. Conversely, FGF21 content increased in interscapular and aortic brown adipose tissue and Sc Ing fat depots, along with the expressions of the Fgf21 receptor and the receptor co-factor beta-klotho. | Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated rats.
Sepa-Kishi DM, Ceddia RB., Free PMC Article | 09/7/2019 |
| FGF21 could potentially attenuate the pathogenic derangements of hypoxia-induced pulmonary hypertension by targeting PPARgamma and inflammatory cytokines | Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPARγ expression and suppressing inflammatory cytokine levels.
Liu J, Cai G, Li M, Fan S, Yao B, Ping W, Huang Z, Cai H, Dai Y, Wang L, Huang X. | 03/30/2019 |
| Beta-klotho is potently regulated by caloric restriction but not by increasing dietary phosphorus intake while FGF21 is regulated by both caloric restriction and increased P intake. | Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake.
Pineda C, Rios R, Raya AI, Rodriguez M, Aguilera-Tejero E, Lopez I., Free PMC Article | 02/2/2019 |
| Study used the high fructose-drinking (HFD) induced hypertension rats as a metabolic syndrome-related hypertension model, and investigated the effects of FGF21 on blood pressure regulation and baroreflex sensitivity. The results extend the work of the FGF21 actions on the neurocontrol of blood pressure regulations through baroreflex afferent pathway in HFD rats. | FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats.
He JL, Zhao M, Xia JJ, Guan J, Liu Y, Wang LQ, Song DX, Qu MY, Zuo M, Wen X, Yu X, Huo R, Pan ZW, Ban T, Zhang Y, Zhu JX, Shou W, Qiao GF, Li BY., Free PMC Article | 07/14/2018 |
| Data (including data from studies in knockout mice) suggest that dietary manipulations that induce ketosis also lead to increased HPA axis tone; FGF21 knockout mice exhibit blunted HPA response to ketogenic diet relative to wild-type mice; thus, the hepatokine FGF21 appears to play important role in response to ketogenic diet. (HPA axis = hypothalamic-pituitary-adrenal axis) | Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21.
Ryan KK, Packard AEB, Larson KR, Stout J, Fourman SM, Thompson AMK, Ludwick K, Habegger KM, Stemmer K, Itoh N, Perez-Tilve D, Tschöp MH, Seeley RJ, Ulrich-Lai YM., Free PMC Article | 02/24/2018 |
| provide the first evidence that FGF21 can inhibit the development of VC by inhibiting the osteogenic transition of VSMCs in rats. FGF21 might be an efficient endogenous vasoprotective factor for calcification. | Fibroblast growth factor 21 ameliorates vascular calcification by inhibiting osteogenic transition in vitamin D3 plus nicotine-treated rats.
Shi Y, Lu W, Hou Y, Fu K, Gan F, Liu J. | 02/24/2018 |
| This study demonstrates that FGF21 action is necessary to achieve the full metabolic benefits of exercise during chronic HF feeding. | Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding.
Loyd C, Magrisso IJ, Haas M, Balusu S, Krishna R, Itoh N, Sandoval DA, Perez-Tilve D, Obici S, Habegger KM., Free PMC Article | 12/16/2017 |
| in the present study we demonstrated behavioral effects induced by central FGF-21 and irisin injections that could involve increased DA signaling in the prefrontal cortex | Effects of central fibroblast growth factor 21 and irisin in anxiety-like behavior.
Chiavaroli A, Recinella L, Ferrante C, Martinotti S, Vacca M, Brunetti L, Orlando G, Leone S. | 12/16/2017 |