| Differential expression and activities of cytochrome P450 3A in the rat brain microsomes and mitochondria. | Differential expression and activities of cytochrome P450 3A in the rat brain microsomes and mitochondria.
Alshammari N, Chandrashekar DV, Rashid M, Mehvar R. | 03/6/2023 |
| This study suggests that there is an impairment of CYP2D and CYP3A metabolism in aging rats. | In vitro metabolism of specific CYP2D and CYP3A opioid substrates using rat liver S9 fractions and mass spectrometry reveal a severe metabolic impairment with increasing age.
Salmin SF, Giroux MC, Vachon P, Beaudry F. | 02/4/2017 |
| The aim of the current work was to study the effect of dexamethasone (DEX) on the gene expression and function of CYP3A23 (in rat), CYP3A28 (in cattle) and the transcriptional factors involved in their regulation. | Gene expression and enzyme function of two cytochrome P450 3A isoenzymes in rat and cattle precision cut liver slices.
Maté ML, Ballent M, Larsen K, Lifschitz A, Lanusse C, Virkel G. | 04/23/2016 |
| mRNA and protein expression of CYP3A were significantly induced and the absorbance and bioavailability of midazolam in rats were reduced | Induction of CYP3A by morroniside in rats.
Xiong S, Li J, Zhang W, Wang X, Zhang Z. | 03/19/2016 |
| CYP3A mRNA expressions in goat and rat gastrointestinal tracts in comparison to the liver were investigated using real-time PCR. | Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts.
Mureithi D, Darwish WS, Ikenaka Y, Kanja L, Ishizuka M. | 02/9/2013 |
| Report a lack of potent drug-drug interactions between both Kampo extract medicines and CYP3A substrate drugs. | Effects of furanocoumarins in Kampo extract-based medicines on rat intestinal absorption of CYP3A and P-glycoprotein substrate drugs in vivo.
Iwanaga K, Arimune K, Miyazaki M, Shibano M, Taniguchi M, Baba K, Kakemi M. | 12/22/2012 |
| Aqueous extract of Schisandra chinensis could show a dual effect on the enzyme activity of CYP3A in rat in vivo. | [Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A].
Chen Q, Wu YJ, Cheng NN, Li YL, Wang YM. | 08/18/2012 |
| Danshen extract affected the metabolism of CYP3A substrates through competitive inhibition in human and rat liver in vitro and had no enzyme inducing effects on rat CYP3A in vivo after chronic administration. | Effects of Salvia miltiorrhiza extract on the liver CYP3A activity in humans and rats.
Wang X, Yeung JH. | 02/25/2012 |
| the poor bioavailability of buagafuran was mostly due to the interplay of P-gp and CYP3A on the absorption, transport and metabolism of buagafuran in intestine | [Effect of CYP3A and P-glycoprotein on the absorption of buagafuran in rat intestinal lumen].
Sheng L, Tan W, Hu JP, Chen H, Li Y. | 02/25/2012 |
| A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16alpha-carbonitrile. | A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile.
Bailey I, Gibson GG, Plant K, Graham M, Plant N., Free PMC Article | 09/3/2011 |
| Hepatic CYP3A and CYP2B subfamily enzymes are decreased during the development of MT adjuvant-induced arthritis. | Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats.
Sanada H, Sekimoto M, Kamoshita A, Degawa M. | 07/23/2011 |
| Data show that only rLSEC-PEM-Hepatocyte cultures exhibited increasing CYP1A1/2 and CYP3A activity. | 3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes.
Kim Y, Rajagopalan P., Free PMC Article | 04/30/2011 |
| Data show that CYP3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein/CHIP E3 ubiquitin ligases. | Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance.
Kim SM, Acharya P, Engel JC, Correia MA., Free PMC Article | 02/26/2011 |
| Using limited plasma sampling is simpler than the usual method of estimating CYP3A phenotyping by predicting the systemic clearance of MDZ when the hepatic activity of CYP3A is reduced in the rat. | Limited sampling strategy in rats to predict the inhibited activities of hepatic CYP3A.
Zhu XH, Jiao JJ, Zhang CL, Lou JS, Liu CX. | 01/21/2010 |
| Repeated intake of green tea extract may aggravate cyclophosphamide-induced body weight loss and malformations of fetuses by modulating CYP2B and CYP3A. | Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA.
Park D, Jeon JH, Shin S, Joo SS, Kang DH, Moon SH, Jang MJ, Cho YM, Kim JW, Ji HJ, Ahn B, Oh KW, Kim YB. | 01/21/2010 |
| CYP3A isoforms play a major role in ecteinascidin 743 rat and human metabolism. | Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans.
Reid JM, Kuffel MJ, Ruben SL, Morales JJ, Rinehart KL, Squillace DP, Ames MM. | 01/21/2010 |
| CYP3a ctributes to liver injury in lipopolysaccharide induced endotoxemia. | CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats.
Minamiyama Y, Takemura S, Toyokuni S, Imaoka S, Funae Y, Hirohashi K, Yoshikawa T, Okada S. | 01/21/2010 |
| Methoxymorpholinyl doxorubicin can be activated by CYP3A metabolism to a potent, long-lived, and cell-permeable cytotoxic metabolite | Antitumor activity of methoxymorpholinyl doxorubicin: potentiation by cytochrome P450 3A metabolism.
Lu H, Waxman DJ. | 01/21/2010 |
| The ability of brain microsomes to catalyze demethylation of erythromycin, and increase in the activity of erythromycin demethylase following pretreatment with dexamethasone or PCN indicates that CYP3A isoenzymes expressed in brain are functionally active | Cytochrome P4503A: evidence for mRNA expression and catalytic activity in rat brain.
Yadav S, Dhawan A, Seth PK, Singh RL, Parmar D. | 01/21/2010 |
| Several fold increase in CYP3A mRNA expression following pretreatment with dexamethasone showed similarities in the regulation of CYP3A isoenzymes in rat blood lymphocytes with the liver enzyme. | Evidence for cytochrome P450 3A expression and catalytic activity in rat blood lymphocytes.
Dey A, Yadav S, Dhawan A, Seth PK, Parmar D. | 01/21/2010 |
| a major enzyme involved in the 2-hydroxylation of 1,4-cineole | Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.
Miyazawa M, Shindo M, Shimada T. | 01/21/2010 |
| Early soy protein consumption has potential effects on the metabolism of a wide variety of CYP3A substrates. | Diets containing soy protein isolate increase hepatic CYP3A expression and inducibility in weanling male rats exposed during early development.
Ronis MJ, Chen Y, Jo CH, Simpson P, Badger TM. | 01/21/2010 |
| CYP3A62 may play major roles together with CYP3A9 and CYP3A18 in endogenous or exogenous detoxification at the absorption site. (cyp3a62) | Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat.
Matsubara T, Kim HJ, Miyata M, Shimada M, Nagata K, Yamazoe Y. | 01/21/2010 |