| A role of Lhx2 in the migration and axonal projection of cortical postmitotic neurons in the cortical upper layer of the mouse neocortex. | A role of Lhx2 in the migration and axonal projection of cortical postmitotic neurons in the cortical upper layer of the mouse neocortex.
Yang H, Ryu J, Gil Y, Ma Y, Nam KH, Jang SW, Shim S. | 10/29/2024 |
| Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma. | Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma.
Li CP, Wu S, Sun YQ, Peng XQ, Gong M, Du HZ, Zhang J, Teng ZQ, Wang N, Liu CM., Free PMC Article | 05/29/2024 |
| Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2. | Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2.
Suresh V, Muralidharan B, Pradhan SJ, Bose M, D'Souza L, Parichha A, Reddy PC, Galande S, Tole S., Free PMC Article | 09/11/2023 |
| LHX2 in germ cells control tubular organization in the developing mouse testis. | LHX2 in germ cells control tubular organization in the developing mouse testis.
Singh N, Singh D, Bhide A, Sharma R, Bhowmick S, Patel V, Modi D. | 03/20/2023 |
| Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis. | Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.
Li X, Gordon PJ, Gaynes JA, Fuller AW, Ringuette R, Santiago CP, Wallace V, Blackshaw S, Li P, Levine EM., Free PMC Article | 12/17/2022 |
| Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary. | Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary.
Singh N, Singh D, Bhide A, Sharma R, Sahoo S, Jolly MK, Modi D. | 04/23/2022 |
| Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone. | Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone.
Saito T, Terajima M, Taga Y, Hayashi F, Oshima S, Kasamatsu A, Okubo Y, Ito C, Toshimori K, Sunohara M, Tanzawa H, Uzawa K, Yamauchi M. | 03/19/2022 |
| REGgamma regulates hair cycle by activating Lgr5 positive hair follicle stem cells. | REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cells.
Gao X, Wang Q, Yuan L, Jiao C, Yu Y, Wang X, Xu P, Ma Y, Wu Y, Wu Z, Li L, Xiao J, Dang Y. | 07/31/2021 |
| An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity. | An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity.
Kinare V, Iyer A, Padmanabhan H, Godbole G, Khan T, Khatri Z, Maheshwari U, Muralidharan B, Tole S. | 01/2/2021 |
| Lhx2 regulates Cux2 expression in cortical layer II-IV during brain development. | Cux2 expression regulated by Lhx2 in the upper layer neurons of the developing cortex.
Yang H, Kim J, Kim Y, Jang SW, Sestan N, Shim S. | 08/13/2020 |
| LHX2 coordinates variations in chromatin accessibility, by competition for nucleosome occupancy and secondary regulation of candidate pioneer factors. | Epigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin.
Zibetti C, Liu S, Wan J, Qian J, Blackshaw S., Free PMC Article | 05/16/2020 |
| Greek-island-bound transcription factor LHX2 and adaptor protein LDB1 regulate the assembly and maintenance of olfactory receptor compartments, Greek island hubs and olfactory receptor transcription, providing mechanistic insights into and functional support for the role of trans interactions in gene expression | LHX2- and LDB1-mediated trans interactions regulate olfactory receptor choice.
Monahan K, Horta A, Lomvardas S., Free PMC Article | 07/6/2019 |
| PAX6 can substitute for LHX2 and override NFIA-induced astrogliogenesis in developing hippocampus in vivo. | PAX6 can substitute for LHX2 and override NFIA-induced astrogliogenesis in developing hippocampus in vivo.
Kinare V, Shetty AS, Suresh A, Tole S. | 08/25/2018 |
| The central role of Lhx2 in organizing and coordinating Muller glia retinal differentiation. | Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis.
de Melo J, Clark BS, Blackshaw S., Free PMC Article | 08/18/2018 |
| these results not only reveal a novel function for LHX2 in regulating dorsoventral patterning in the telencephalon, but also identify PAX6 as a fundamental regulator of where the hem can form, and therefore implicate this molecule as a determinant of hippocampal positioning. | Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes.
Godbole G, Roy A, Shetty AS, Tole S., Free PMC Article | 07/28/2018 |
| The authors show that transcription factors Lhx2 and Ebf specify olfactory receptor enhancers by binding in a functionally cooperative fashion to stereotypically spaced motifs that defy heterochromatin. | Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons.
Monahan K, Schieren I, Cheung J, Mumbey-Wafula A, Monuki ES, Lomvardas S., Free PMC Article | 06/16/2018 |
| These findings show that control of Lhx2 function by Ldb1 and Rnf12 underpins the coordinated differentiation of neurons and Muller glia in postnatal retina. | Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina.
de Melo J, Clark BS, Venkataraman A, Shiau F, Zibetti C, Blackshaw S., Free PMC Article | 05/26/2018 |
| Foxg1 and Lhx2 form a genetic hierarchy in the spatiotemporal regulation of cortical hem specification and positioning, and together ensure the normal development of this hippocampal organizer. | Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon.
Godbole G, Shetty AS, Roy A, D'Souza L, Chen B, Miyoshi G, Fishell G, Tole S., Free PMC Article | 03/31/2018 |
| LIM homeobox protein 2 confers neuronal competency for activity-dependent dendritic development in L4 neurons by inducing the expression of BTB domain containing 3. | Lhx2 Expression in Postmitotic Cortical Neurons Initiates Assembly of the Thalamocortical Somatosensory Circuit.
Wang CF, Hsing HW, Zhuang ZH, Wen MH, Chang WJ, Briz CG, Nieto M, Shyu BC, Chou SJ. | 12/23/2017 |
| Lhx2 regulates Dmrt5: loss of either factor promotes gliogenesis and overexpression of either factor promotes neurogenesis. | Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus.
Muralidharan B, Keruzore M, Pradhan SJ, Roy B, Shetty AS, Kinare V, D'Souza L, Maheshwari U, Karmodiya K, Suresh A, Galande S, Bellefroid EJ, Tole S., Free PMC Article | 12/2/2017 |
| Neuroretinal expression of Lhx2 and neuroretina-derived FGF factors are crucial for lens fiber development in vivo. | Control of lens development by Lhx2-regulated neuroretinal FGFs.
Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S., Free PMC Article | 09/16/2017 |
| LHX2 is a key component of the control network for producing neurons that will participate in cortical circuitry | LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11.
Muralidharan B, Khatri Z, Maheshwari U, Gupta R, Roy B, Pradhan SJ, Karmodiya K, Padmanabhan H, Shetty AS, Balaji C, Kolthur-Seetharam U, Macklis JD, Galande S, Tole S., Free PMC Article | 07/29/2017 |
| We found that expression of Emx2 and Lhx2 initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 and Meis2 were only expressed in the apical layer, together with Gnai2, but not in the basal layer. | Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages.
Chang I, Parrilla M. | 05/27/2017 |
| Lhx2 is required for maintenance of the corneal epithelial cell compartment and the limbal barrier. | LIM Homeobox Domain 2 Is Required for Corneal Epithelial Homeostasis.
Sartaj R, Chee RI, Yang J, Wan P, Liu A, Guaiquil V, Fuchs E, Rosenblatt MI., Free PMC Article | 11/5/2016 |
| The ectopic expression of Lhx2 in OP9 cells (OP9-Lhx2) accelerates the hematopoietic differentiation of PSCs. | OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo.
Chen X, Zhao Q, Li C, Geng Y, Huang K, Zhang J, Wang X, Yang J, Wang T, Xia C, Liu X, Meng M, Yang D, Zheng Y, Du J, Zhang X, Chen J, Pan G, Wang J. | 08/6/2016 |