Lama1 upregulation prolongs the lifespan of the dy[H]/dy[H] mouse model of LAMA2-related congenital muscular dystrophy. | Lama1 upregulation prolongs the lifespan of the dy(H)/dy(H) mouse model of LAMA2-related congenital muscular dystrophy. Liu Y, Tan D, Ma K, Luo H, Mao J, Luo J, Shen Q, Xu L, Yang S, Ge L, Guo Y, Zhang H, Xiong H. | 10/9/2024 |
Effects of experimental glaucoma in Lama1[nmf223] mutant mice. | Effects of experimental glaucoma in Lama1(nmf223) mutant mice. Madhoun S, Martins MTC, Korneva A, Johnson TV, Kimball E, Quillen S, Pease ME, Edwards M, Quigley H., Free PMC Article | 02/11/2023 |
Effect of laminin environments and tumor factors on the biology of myeloid dendritic cells. | Effect of laminin environments and tumor factors on the biology of myeloid dendritic cells. Phillippi B, Singh M, Loftus T, Smith H, Muccioli M, Wright J, Pate M, Benencia F. | 01/9/2021 |
Sleep deprivation regulates availability of PrP(C) and Abeta peptides which can impair interaction between PrP(C) and laminin and neuronal plasticity. | Sleep deprivation regulates availability of PrP(C) and Aβ peptides which can impair interaction between PrP(C) and laminin and neuronal plasticity. da Luz MHM, Pino JMV, Santos TG, Antunes HKM, Martins VR, de Souza AAL, Torquato RJS, Lee KS., Free PMC Article | 11/21/2020 |
Lama1 as the genetic modifier of TGF-beta1 effector responses that significantly affects the development of pulmonary fibrosis. | Laminin α1 is a genetic modifier of TGF-β1-stimulated pulmonary fibrosis. Lee CM, Cho SJ, Cho WK, Park JW, Lee JH, Choi AM, Rosas IO, Zheng M, Peltz G, Lee CG, Elias JA., Free PMC Article | 11/16/2019 |
Laminin alpha1 reduces muscular dystrophy in dy(2J) mice. | Laminin α1 reduces muscular dystrophy in dy(2J) mice. Gawlik KI, Harandi VM, Cheong RY, Petersén Å, Durbeej M. | 03/2/2019 |
laminin-1 does not have a positive effect on ENCC migration in HD mice on E12.5, in contrast to the phenomenon seen in normal mice gut specimens, where laminin-1 promotes ENCC migration during the same period. | The effect of laminin-1 on enteric neural crest-derived cell migration in the Hirschsprung's disease mouse model. Nakazawa-Tanaka N, Fujiwara N, Miyahara K, Nakada S, Arikawa-Hirasawa E, Akazawa C, Urao M, Yamataka A. | 07/21/2018 |
Altered LAMA1 expression in the aganglionic region may contribute to impaired ENCC migration, resulting in HD. These data could help in understanding the pathophysiologic interactions between LAMA1 and ENCC migration | Altered expression of laminin alpha1 in aganglionic colon of endothelin receptor-B null mouse model of Hirschsprung's disease. Fujiwara N, Nakazawa-Tanaka N, Miyahara K, Arikawa-Hirasawa E, Akazawa C, Yamataka A. | 07/21/2018 |
Laminin is instructive and CaMKII is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture. | Laminin is instructive and calmodulin dependent kinase II is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture. Vezina-Audette R, Tremblay M, Carbonetto S. | 01/6/2018 |
Laminin differentially regulates the stemness of type I and type II pericytes. | Laminin differentially regulates the stemness of type I and type II pericytes. Gautam J, Nirwane A, Yao Y., Free PMC Article | 11/11/2017 |
Laminin regulates PDGFRbeta cell differentiation, fate determination, cell stemness and muscle development via gpihbp1. | Laminin regulates PDGFRβ(+) cell stemness and muscle development. Yao Y, Norris EH, Mason CE, Strickland S., Free PMC Article | 09/10/2016 |
while MMP-9 is not essential for hypoxic-induced cerebral angiogenesis, it plays an important role in post-hypoxic vascular pruning by degrading laminin and claudin-5 | Matrix metalloproteinase-9 mediates post-hypoxic vascular pruning of cerebral blood vessels by degrading laminin and claudin-5. Boroujerdi A, Welser-Alves JV, Milner R. | 04/9/2016 |
interaction of alpha6beta1 in embryonic stem cells (ECCs) with laminin-1 activates alpha6beta1/CD151 signaling which programs ESCs toward the endothelial cells lineage fate | Integrin α6β1 Expressed in ESCs Instructs the Differentiation to Endothelial Cells. Toya SP, Wary KK, Mittal M, Li F, Toth PT, Park C, Rehman J, Malik AB., Free PMC Article | 03/19/2016 |
These findings suggest that LAMA1 plays a critical role in kidney function and kidney aging by regulating the mesangial cell population and mesangial matrix deposition through TGF-beta/Smad signaling. | Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-β pathway. Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner JH, Arikawa-Hirasawa E., Free PMC Article | 01/3/2015 |
alpha1- and alpha5-containing laminins differentially regulate the sequential events to form epithelial tissues via beta1 integrin signals. | α1- and α5-containing laminins regulate the development of bile ducts via β1 integrin signals. Tanimizu N, Kikkawa Y, Mitaka T, Miyajima A., Free PMC Article | 11/3/2012 |
Mutations in Lama1 allow developing retinal vessels to enter the vitreous where they anastomose with vessels of the hyaloid system which persist and expand | Lama1 mutations lead to vitreoretinal blood vessel formation, persistence of fetal vasculature, and epiretinal membrane formation in mice. Edwards MM, McLeod DS, Grebe R, Heng C, Lefebvre O, Lutty GA., Free PMC Article | 06/23/2012 |
-DG prepared from lung- or testis-derived cells lacks the post-phosphoryl moiety and shows little laminin a1 and a2 binding activity. | Absence of post-phosphoryl modification in dystroglycanopathy mouse models and wild-type tissues expressing non-laminin binding form of α-dystroglycan. Kuga A, Kanagawa M, Sudo A, Chan YM, Tajiri M, Manya H, Kikkawa Y, Nomizu M, Kobayashi K, Endo T, Lu QL, Wada Y, Toda T., Free PMC Article | 06/16/2012 |
Our data show that the absence of Lama1 has an impact on the Bergmann glia scaffold that aberrantly develops. | Functional role of laminin α1 chain during cerebellum development. Heng C, Lefebvre O, Klein A, Edwards MM, Simon-Assmann P, Orend G, Bagnard D., Free PMC Article | 05/19/2012 |
Laminin alpha1 is essential for mouse cerebellar development. | Laminin α1 is essential for mouse cerebellar development. Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai T, Kohsaka S, Chiba H, Hattori N, Yamada Y, Arikawa-Hirasawa E., Free PMC Article | 05/5/2012 |
Laminin promotes epithelial formation of XEN cells, and up-regulation of visceral endoderm markers. | BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm. Paca A, Séguin CA, Clements M, Ryczko M, Rossant J, Rodriguez TA, Kunath T. | 02/4/2012 |
Laminin alpha1 chain is not responsible for muscle disease in the mdx mouse model for Duchenne muscular dystrophy | Transgenic expression of Laminin α1 chain does not prevent muscle disease in the mdx mouse model for Duchenne muscular dystrophy. Gawlik KI, Oliveira BM, Durbeej M., Free PMC Article | 07/16/2011 |
The results show that laminin alpha1LG domains and consequently their receptors have disparate functions in the neuromuscular system | Distinct roles for laminin globular domains in laminin alpha1 chain mediated rescue of murine laminin alpha2 chain deficiency. Gawlik KI, Akerlund M, Carmignac V, Elamaa H, Durbeej M., Free PMC Article | 10/30/2010 |
we analyze the lifespan of laminin alpha2 chain-deficient mice with transgenic overexpression of laminin alpha1 chain | Transgenic overexpression of laminin alpha1 chain in laminin alpha2 chain-deficient mice rescues the disease throughout the lifespan. Gawlik KI, Durbeej M. | 07/19/2010 |
This first report of viable Lama1 mouse mutants emphasizes the importance of this gene in retinal development, and data suggest that hypomorphic mutations in human LAMA1 could lead to retinal disease. | Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation. Edwards MM, Mammadova-Bach E, Alpy F, Klein A, Hicks WL, Roux M, Simon-Assmann P, Smith RS, Orend G, Wu J, Peachey NS, Naggert JK, Lefebvre O, Nishina PM., Free PMC Article | 05/3/2010 |
Data suggest that laminin alpha1 domains LG4-5 provide an autocrine signal necessary for the complete differentiation of a functional visceral endoderm and vital signals for the polarization of the epiblast. | Laminin alpha1 domains LG4-5 are essential for the complete differentiation of visceral endoderm. Akerlund M, Carmignac V, Schéele S, Durbeej M. | 01/21/2010 |