| Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A) heterodimeric receptor is widely expressed among M. musculus subspecies musculus. | Evidence of functional Cd94 polymorphism in a free-living house mouse population.
Knutsen LE, Dissen E, Saether PC, Bjørnsen EG, Piálek J, Storset AK, Boysen P. | 09/7/2019 |
| Segregation of a spontaneous Klrd1 mutation in DBA/2 mouse substrains | Segregation of a spontaneous Klrd1 (CD94) mutation in DBA/2 mouse substrains.
Shin DL, Pandey AK, Ziebarth JD, Mulligan MK, Williams RW, Geffers R, Hatesuer B, Schughart K, Wilk E., Free PMC Article | 11/21/2015 |
| The transmembrane region sequences of CD94 and NKG2 in mouse and rat differ markedly from other mammalian orthologs by the presence of a lysine residue in the transmembrane region. | Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
Saether PC, Hoelsbrekken SE, Fossum S, Dissen E. | 02/11/2012 |
| The complex interplay between various stimuli may account for the variable expression of CD94/NKG2A during responses to different pathogens in vivo. | Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells.
Cho JH, Kim HO, Webster K, Palendira M, Hahm B, Kim KS, King C, Tangye SG, Sprent J. | 09/3/2011 |
| expression of CD94 and its associated NKG2A, NKG2C, and NKG2E subunits is dispensable for NK cell development, education, and many NK cell functions | Development and function of CD94-deficient natural killer cells.
Orr MT, Wu J, Fang M, Sigal LJ, Spee P, Egebjerg T, Dissen E, Fossum S, Phillips JH, Lanier LL., Free PMC Article | 07/9/2011 |
| show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus | CD94 is essential for NK cell-mediated resistance to a lethal viral disease.
Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL, Sigal LJ., Free PMC Article | 06/18/2011 |
| CD94 is an Ag that can be used to identify functionally distinct NK cell subsets in mice and could also be relevant to late-stage mouse NK cell development. | CD94 defines phenotypically and functionally distinct mouse NK cell subsets.
Yu J, Wei M, Mao H, Zhang J, Hughes T, Mitsui T, Park IK, Hwang C, Liu S, Marcucci G, Trotta R, Benson DM Jr, Caligiuri MA., Free PMC Article | 01/21/2010 |
| CD94 and NKG2 were both expressed early in NK cell development, sometimes in the absence of NK1.1, with CD94 invariably being expressed at two different levels. IL-4 differentially inhibited the expression of CD94 and Ly49 receptors. | NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2.
Fraser KP, Gays F, Robinson JH, van Beneden K, Leclercq G, Vance RE, Raulet DH, Brooks CG. | 01/21/2010 |
| There is no evidence that CD94 inhibits either the lytic function of lymphocytic choriomeningitis virus-specific T cells or their capacity to produce effector cytokines upon peptide stimulation. | CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
Miller JD, Peters M, Oran AE, Beresford GW, Harrington L, Boss JM, Altman JD. | 01/21/2010 |
| results indicate that LTbetaR-mediated signals are not required for Ly49 and CD94/NKG2 receptor acquisition on NK cells | Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression.
Stevenaert F, Van Beneden K, De Colvenaer V, Franki AS, Debacker V, Boterberg T, Deforce D, Pfeffer K, Plum J, Elewaut D, Leclercq G. | 01/21/2010 |
| The acquisition of individual receptor gene expressions during various stages of differentiation in culture from embryonic stem cells to NK cells follows a predetermined order, with the order of receptor acquisition being first CD94. | Orderly and nonstochastic acquisition of CD94/NKG2 receptors by developing NK cells derived from embryonic stem cells in vitro.
Lian RH, Maeda M, Lohwasser S, Delcommenne M, Nakano T, Vance RE, Raulet DH, Takei F. | 01/21/2010 |
| Inhibitory receptor CD94 is expressed on mature fetal thymic and adult epidermal TCR Vgamma3+ lymphocytes. | Expression of inhibitory receptors Ly49E and CD94/NKG2 on fetal thymic and adult epidermal TCR V gamma 3 lymphocytes.
Van Beneden K, De Creus A, Stevenaert F, Debacker V, Plum J, Leclercq G. | 01/21/2010 |
| Identification of a novel second CD94 upstream CD94 promoter and the observation that various lymphoid cells use the two promoters differentially offer a theoretical mechanism for the expression of NK receptors on non-NK cells. | Transcriptional control of murine CD94 gene: differential usage of dual promoters by lymphoid cell types.
Wilhelm BT, Landry JR, Takei F, Mager DL. | 01/21/2010 |
| the CD94/NKG2A inhibitory receptor plays a critical role in down-regulating invariant NK-cell responses | IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.
Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K., Free PMC Article | 01/21/2010 |
| The engagement of the activating isoforms of C-type lectin inhibitory receptor (CD94)by their natural ligands, represented by soluble HLA-I molecules, induced programmed cell death of natural killer cells | Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction.
Spaggiari GM, Contini P, Dondero A, Carosio R, Puppo F, Indiveri F, Zocchi MR, Poggi A. | 01/21/2010 |
| Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. | Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.
Vance RE, Jamieson AM, Cado D, Raulet DH., Free PMC Article | 01/21/2010 |
| CD94 heterodimers costimulate effector functions of differentiated Th1 cells, but not Th2 cells. | Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions.
Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK. | 01/21/2010 |
| A high level of expression of CD94/NKG2 receptors is correlated with a lower level of apoptosis and may play an important role in the maintenance of CD8 T and NK cells. | Preferential survival of CD8 T and NK cells expressing high levels of CD94.
Gunturi A, Berg RE, Forman J. | 01/21/2010 |
| CD94-expressing anti-polyoma virus CD8 T cells appear to be essential for antigen-specific recall responses in mice persistently infected by polyoma virus. | CD94/NKG2A expression is associated with proliferative potential of CD8 T cells during persistent polyoma virus infection.
Byers AM, Andrews NP, Lukacher AE. | 01/21/2010 |