| tissue kallikrein knockout mice had a significant two-fold increase in albuminuria | Kallikrein protects against microalbuminuria in experimental type I diabetes.
Bodin S, Chollet C, Goncalves-Mendes N, Gardes J, Pean F, Heudes D, Bruneval P, Marre M, Alhenc-Gelas F, Bouby N. | 02/22/2016 |
| Tissue kallikrein and kinins do not influence the trophicity of kidneys, the synthesis and secretion of renin, blood pressure increase, and cardiac remodeling due to renin angiotensin system activation. | Tissue kallikrein deficiency and renovascular hypertension in the mouse.
Griol-Charhbili V, Sabbah L, Colucci J, Vincent MP, Baudrie V, Laude D, Elghozi JL, Bruneval P, Picard N, Meneton P, Alhenc-Gelas F, Richer C. | 02/22/2016 |
| TK, like several other proteases, can activate ENaC in the kidney and the colon. | Defective ENaC processing and function in tissue kallikrein-deficient mice.
Picard N, Eladari D, El Moghrabi S, Planès C, Bourgeois S, Houillier P, Wang Q, Burnier M, Deschenes G, Knepper MA, Meneton P, Chambrey R. | 02/22/2016 |
| Protective effects of Tissue kallikrein gene transfer on ischemic diseases. | Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium.
Spillmann F, Graiani G, Van Linthout S, Meloni M, Campesi I, Lagrasta C, Westermann D, Tschöpe C, Quaini F, Emanueli C, Madeddu P. | 02/22/2016 |
| Polypeptides identified based on immunorecognition by autoantibodies in sera from IQI/Jic mice affected with autoimmune disease (>12 weeks of age) were tissue kallikrein (Klk)-1 and -13 and were cross-reactive to the autoantibodies. | Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndrome.
Takada K, Takiguchi M, Konno A, Inaba M. | 02/22/2016 |
| The study suggests that kallikrein plays an antihypertensive role in hyperaldosteronism. | Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.
Waeckel L, Potier L, Chollet C, Taveau C, Bruneval P, Roussel R, Alhenc-Gelas F, Bouby N. | 02/22/2016 |
| These data do not support a role for the TK-kinin system, protective or deleterious, in the development of insulin resistance and diabetes. | Tissue kallikrein deficiency, insulin resistance, and diabetes in mouse and man.
Potier L, Waeckel L, Fumeron F, Bodin S, Fysekidis M, Chollet C, Bellili N, Bonnet F, Gusto G, Velho G, Marre M, Alhenc-Gelas F, Roussel R, Bouby N, DESIR Study Group. | 02/22/2016 |
| Lower excretion of active renin and prorenin in TK(-/-) compared to TK(+/+) suggest coordinated regulation of the two proteins in their participation to collecting duct function. | Renin and kallikrein in connecting tubule of mouse.
Rohrwasser A, Ishigami T, Gociman B, Lantelme P, Morgan T, Cheng T, Hillas E, Zhang S, Ward K, Bloch-Faure M, Meneton P, Lalouel JM. | 02/22/2016 |
| Plasma kallikrein-deficient mice challenged with transient middle cerebral artery occlusion developed significantly smaller brain infarctions. | Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation.
Göb E, Reymann S, Langhauser F, Schuhmann MK, Kraft P, Thielmann I, Göbel K, Brede M, Homola G, Solymosi L, Stoll G, Geis C, Meuth SG, Nieswandt B, Kleinschnitz C. | 06/27/2015 |
| Local expression of kallikreins within the kidney has the capacity to dampen lupus nephritis, possibly by modulating inflammation and oxidative stress. | Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis.
Shao X, Yang R, Yan M, Li Y, Du Y, Raman I, Zhang B, Wakeland EK, Igarashi P, Mohan C, Li QZ. | 04/27/2013 |
| The data of this study presented support the conclusion that Klk6 is an important participant in the immunopathogenic events that drive TMEV-IDD at acute through early chronic time points. | Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.
Scarisbrick IA, Yoon H, Panos M, Larson N, Blaber SI, Blaber M, Rodriguez M., Free PMC Article | 04/27/2013 |
| Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells. | Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells.
Spinetti G, Fortunato O, Cordella D, Portararo P, Kränkel N, Katare R, Sala-Newby GB, Richer C, Vincent MP, Alhenc-Gelas F, Tonolo G, Cherchi S, Emanueli C, Madeddu P., Free PMC Article | 04/16/2011 |
| These findings indicate that kallikreins play an important protective role in autoantibody-initiated glomerulonephritis (GN) and could constitute potential candidate genes for anti-glomerular basement membrane-induced GN and spontaneous lupus nephritis. | The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis.
Li QZ, Zhou J, Yang R, Yan M, Ye Q, Liu K, Liu S, Shao X, Li L, Zhou XJ, Wakeland EK, Mohan C., Free PMC Article | 01/21/2010 |
| Gene-transfer of wild-type Ad.hKLK1 (kallikrein 1) was able to rescue impaired muscle neovascularization in hindlimb ischemia in knockout mice | Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization.
Stone OA, Richer C, Emanueli C, van Weel V, Quax PH, Katare R, Kraenkel N, Campagnolo P, Barcelos LS, Siragusa M, Sala-Newby GB, Baldessari D, Mione M, Vincent MP, Benest AV, Al Haj Zen A, Gonzalez J, Bates DO, Alhenc-Gelas F, Madeddu P., Free PMC Article | 01/21/2010 |
| KLK6, but not KLK1 is an activator of CNS protease-activated receptors | Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines.
Vandell AG, Larson N, Laxmikanthan G, Panos M, Blaber SI, Blaber M, Scarisbrick IA., Free PMC Article | 01/21/2010 |
| role of KLK1 in arterial function; role of KLK1 in the control of ionic transport in the renal tubule; cardio- and nephro-protective effects of KLK1 and kinins in acute cardiac ischemia, post-ischemic heart failure, and diabetes [review] | Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney.
Pizard A, Richer C, Bouby N, Picard N, Meneton P, Azizi M, Alhenc-Gelas F. | 01/21/2010 |
| These results suggest that LPS activates the kallikrein-kinin system in the choroid plexus via autocrine induction of IL-1beta and TNF-alpha. | Lipopolysaccharide activates the kallikrein-kinin system in mouse choroid plexus cell line ECPC4.
Takano M, Satoh C, Kunimatsu N, Otani M, Hamada-Kanazawa M, Miyake M, Ming K, Yayama K, Okamoto H. | 01/21/2010 |
| Data suggest that tissue kallikrein 1 may be implicated in the growth of uterine endometrial tissues during the proliferative phase. | Estrogen-dependent expression of the tissue kallikrein gene (Klk1) in the mouse uterus and its implications for endometrial tissue growth.
Rajapakse S, Yamano N, Ogiwara K, Hirata K, Takahashi S, Takahashi T. | 01/21/2010 |
| Tissue-specific expression patterns and differential regulation in CNS disease indicates that each K6 5'-transcript is probably regulated by unique promoter elements and may serve as a molecular target to treat inflammatory demyelinating disease. | Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease.
Christophi GP, Isackson PJ, Blaber S, Blaber M, Rodriguez M, Scarisbrick IA. | 01/21/2010 |
| kallikrein 6 is expressed in the nonmalignant and malignant prostate, with cancer tissues demonstrating slightly lower expression | Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues.
Petraki CD, Gregorakis AK, Papanastasiou PA, Karavana VN, Luo LY, Diamandis EP. | 01/21/2010 |
| Kallikrein 6 participates in enzymatic cascades mediating CNS inflammatory disease. | Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease.
Blaber SI, Ciric B, Christophi GP, Bernett MJ, Blaber M, Rodriguez M, Scarisbrick IA. | 01/21/2010 |