| Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis. | Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis.
Liu JC, Pan ZN, Ju JQ, Zou YJ, Pan MH, Wang Y, Wu X, Sun SC., Free PMC Article | 04/10/2024 |
| Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile. | Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile.
Stevens ML, Mersha TB, Zhang Z, Kothari A, Khurana Hershey GK., Free PMC Article | 06/11/2022 |
| Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function. | Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Gailey CD, Wang EJ, Jin L, Ahmadi S, Brautigan DL, Li X, Xu W, Scott MM, Fu Z., Free PMC Article | 01/22/2022 |
| Photoreceptor Compartment-Specific TULP1 Interactomes. | Photoreceptor Compartment-Specific TULP1 Interactomes.
Ebke LA, Sinha S, Pauer GJT, Hagstrom SA., Free PMC Article | 09/11/2021 |
| KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step. | KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step.
Quinn SM, Vargason T, Pokhrel N, Antony E, Hahn J, Gilbert SP., Free PMC Article | 08/7/2021 |
| The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C. | The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C.
Bensel BM, Woody MS, Pyrpassopoulos S, Goldman YE, Gilbert SP, Ostap EM., Free PMC Article | 09/12/2020 |
| Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. | Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
Stevens ML, Zhang Z, Johansson E, Ray S, Jagpal A, Ruff BP, Kothari A, He H, Martin LJ, Ji H, Wikenheiser-Brokamp K, Weirauch MT, Supp DM, Biagini Myers JM, Khurana Hershey GK., Free PMC Article | 09/12/2020 |
| there may be a potential correlation between Pitchfork and Kif3a that could regulate primary cilia disassembly during palate development | The correlative hypotheses between Pitchfork and Kif3a in palate development.
Li S, Jin S, Jin C. | 12/7/2019 |
| Study demonstrates that the non-canonical SMO/Gi/RHOA pathway functions outside primary cilia: Kif3a-deficient fibroblasts, unable to form primary cilia and to activate the canonical Hedgehog pathway, can activate RHOA robustly after stimulation of endogenous SMO with SHH or purmorphamine, and that KIF3A re-expression rescues ciliogenesis but does not affect RHOA activation. | Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia.
Ho Wei L, Arastoo M, Georgiou I, Manning DR, Riobo-Del Galdo NA., Free PMC Article | 02/16/2019 |
| KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma | KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.
Geng G, Du Y, Dai J, Tian D, Xia Y, Fu Z. | 08/11/2018 |
| Cell senescence is a central feature in nephronophthisis type 7 and Kif3a is unexpectedly required for efficient DNA damage response and cell cycle arrest. | Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.
Lu D, Rauhauser A, Li B, Ren C, McEnery K, Zhu J, Chaki M, Vadnagara K, Elhadi S, Jetten AM, Igarashi P, Attanasio M., Free PMC Article | 09/30/2017 |
| The results show for KIF3AB that the kinetics of microtubule association is less than the rates observed for KIF3AA or KIF3BB. | Heterodimerization of Kinesin-2 KIF3AB Modulates Entry into the Processive Run.
Albracht CD, Guzik-Lendrum S, Rayment I, Gilbert SP., Free PMC Article | 09/30/2017 |
| genetically ablated Kif3a, Ift88, and Ttc21b in a series of specific spatiotemporal domains. The resulting phenotypes allow us to draw several conclusions. First, we conclude that the Ttc21b cortical phenotype is not due to the activity of Ttc21b within the brain itself | Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development.
Snedeker J, Schock EN, Struve JN, Chang CF, Cionni M, Tran PV, Brugmann SA, Stottmann RW., Free PMC Article | 09/9/2017 |
| Airway epithelial KIF3A suppresses Th2 pulmonary inflammation and airway hyperresponsiveness following aeroallergen exposure, implicating epithelial microtubular functions in the pathogenesis of Th2-mediated lung pathology. | Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens.
Giridhar PV, Bell SM, Sridharan A, Rajavelu P, Kitzmiller JA, Na CL, Kofron M, Brandt EB, Ericksen M, Naren AP, Moon C, Khurana Hershey GK, Whitsett JA., Free PMC Article | 07/29/2017 |
| Longitudinal microcomputed tomography (muCT) imaging and histopathological analyses revealed an increased rate of cyst formation, increased proportion of cysts with proliferating cells, higher frequency of atypical cysts as well as the development of neoplasms in Vhl/Kif3a/Trp53 mutant kidneys compared to Kif3a/Trp53 or Vhl/Kif3a mutant kidneys. | Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.
Guinot A, Lehmann H, Wild PJ, Frew IJ. | 06/10/2017 |
| Study found that both KIF3AC and KIF3AB can traverse long distances over the microtubule track, revealing that these motors are adept and well-tuned for their specialized roles as cargo transporters | Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules.
Guzik-Lendrum S, Rank KC, Bensel BM, Taylor KC, Rayment I, Gilbert SP., Free PMC Article | 08/6/2016 |
| Data suggest biocatalysis by Kif3a homodimer, Kif3c homodimer, or Kif3a/Kif3c heterodimer vary; microtubule interaction is very fast for Kif3a homodimer; Kif3c homodimer interaction is much slower; Kif3a/Kif3c heterodimer interaction is intermediate. | Fast or Slow, Either Head Can Start the Processive Run of Kinesin-2 KIF3AC.
Zhang P, Rayment I, Gilbert SP., Free PMC Article | 08/6/2016 |
| KIF1-binding protein interacts with KIF3A in haploid male germ cells, promoting spermatid elongation. | KIF1-binding protein interacts with KIF3A in haploid male germ cells.
Lehti MS, Kotaja N, Sironen A. | 05/14/2016 |
| Vhl and Kif3a deletion accelerates renal cyst formation | Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.
Lehmann H, Vicari D, Wild PJ, Frew IJ., Free PMC Article | 02/27/2016 |
| The results of this study suggested thatactivity-dependent cargo loading, in which phosphorylation of the KIF3A C terminus upregulates the loading and transport of N-cadherin in homeostatic synaptic plasticity. | Mechanism of Activity-Dependent Cargo Loading via the Phosphorylation of KIF3A by PKA and CaMKIIa.
Ichinose S, Ogawa T, Hirokawa N. | 11/28/2015 |
| The results demonstrate that visual pigments transport to the retinal outer segment despite removal of KIF3 and IFT88, and KIF3-mediated anterograde IFT is responsible for photoreceptor transition zone and axoneme formation. | Heterotrimeric kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptors.
Jiang L, Wei Y, Ronquillo CC, Marc RE, Yoder BK, Frederick JM, Baehr W., Free PMC Article | 08/1/2015 |
| Processivity of the kinesin-2 KIF3A results from rear head gating and not front head gating. | Processivity of the kinesin-2 KIF3A results from rear head gating and not front head gating.
Chen GY, Arginteanu DF, Hancock WO., Free PMC Article | 06/20/2015 |
| A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a | A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Liu B, Chen S, Johnson C, Helms JA. | 05/16/2015 |
| KIF3AB exhibits novel ATPase activity. | Kinesin-2 KIF3AB exhibits novel ATPase characteristics.
Albracht CD, Rank KC, Obrzut S, Rayment I, Gilbert SP., Free PMC Article | 12/20/2014 |
| single-molecule motility from different kinesin-1 and kinesin-2 neck-linker chimeras stepping along microtubules, was studied. | Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface.
Hoeprich GJ, Thompson AR, McVicker DP, Hancock WO, Berger CL., Free PMC Article | 12/6/2014 |