| KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1. | KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1.
Li M, Fang Q, Xiao P, Yin Z, Mei G, Wang C, Xiang Y, Zhao X, Qu L, Xu T, Zhang J, Liu K, Li X, Dong H, Xiao R, Zhou R., Free PMC Article | 08/28/2024 |
| KSRP improves pancreatic beta cell function and survival. | KSRP improves pancreatic beta cell function and survival.
Barssotti L, Soares GM, Marconato-Júnior E, Lourençoni Alves B, Oliveira KM, Carneiro EM, Boschero AC, Barbosa HCL., Free PMC Article | 03/15/2024 |
| KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization. | KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization.
Olguin SL, Patel P, Buchanan CN, Dell'Orco M, Gardiner AS, Cole R, Vaughn LS, Sundararajan A, Mudge J, Allan AM, Ortinski P, Brigman JL, Twiss JL, Perrone-Bizzozero NI., Free PMC Article | 07/16/2022 |
| Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Fas(lpr) Mice. | Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Fas(lpr) Mice.
Schmidtke L, Meineck M, Saurin S, Otten S, Gather F, Schrick K, Käfer R, Roth W, Kleinert H, Weinmann-Menke J, Pautz A., Free PMC Article | 12/18/2021 |
| FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells. | FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells.
Zheng Y, Dubois W, Benham C, Batchelor E, Levens D., Free PMC Article | 06/26/2021 |
| The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally. | The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
Schmidtke L, Schrick K, Saurin S, Käfer R, Gather F, Weinmann-Menke J, Kleinert H, Pautz A. | 09/7/2019 |
| Report KSRP/mRNA/microRNA interactions in chromatoid body of spermatids regulating spermatogenesis. | KH-type splicing regulatory protein is a new component of chromatoid body.
Zhang H, Wang G, Liu L, Liang X, Lin Y, Lin YY, Chou CF, Liu MF, Huang H, Sun F. | 06/30/2018 |
| CXCL-2 and HMOX-1 were upregulated in H. pylori infection after KSRP overexpression. This difference in expression of these genes implicated that KSRP was closely associated with and directly participated in the innate immune response against H. pylori. | Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.
Li N, Cao M, Yi S, Cheng J, Wang L, Tao Y, Wu D, Peng J, Zhang M, Qi P, Zhao J. | 02/24/2018 |
| IFN-gamma production was increased in spleen cells of KSRP(-/-) mice. | Inactivation of the KSRP gene modifies collagen antibody induced arthritis.
Käfer R, Schrick K, Schmidtke L, Montermann E, Hobernik D, Bros M, Chen CY, Kleinert H, Pautz A. | 09/16/2017 |
| Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1. | Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells.
Moshiri A, Puppo M, Rossi M, Gherzi R, Briata P. | 08/19/2017 |
| KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression | KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression.
Chou CF, Zhu X, Lin YY, Gamble KL, Garvey WT, Chen CY., Free PMC Article | 10/24/2015 |
| KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons. | KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
Bird CW, Gardiner AS, Bolognani F, Tanner DC, Chen CY, Lin WJ, Yoo S, Twiss JL, Perrone-Bizzozero N., Free PMC Article | 11/29/2014 |
| This study reveals the in vivo function of KSRP in controlling brown-like transformation of subcutaneous/inguinal white adipose tissue through post-transcriptional regulation of miR-150 expression. | KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression.
Chou CF, Lin YY, Wang HK, Zhu X, Giovarelli M, Briata P, Gherzi R, Garvey WT, Chen CY., Free PMC Article | 11/8/2014 |
| This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR-145 expression. | KSRP and MicroRNA 145 are negative regulators of lipolysis in white adipose tissue.
Lin YY, Chou CF, Giovarelli M, Briata P, Gherzi R, Chen CY., Free PMC Article | 10/4/2014 |
| KSRP is required to maintain P19 cells in undifferentiated state and that its inactivation can orient cells towards neural differentiation. | KSRP silencing favors neural differentiation of P19 teratocarcinoma cells.
Giovarelli M, Bucci G, Pasero M, Gherzi R, Briata P. | 07/20/2013 |
| Our results outline a critical role for KSRP in regulating pro-inflammatory mediators and have implications for a wide range of CNS inflammatory and autoimmune diseases. | KSRP: a checkpoint for inflammatory cytokine production in astrocytes.
Li X, Lin WJ, Chen CY, Si Y, Zhang X, Lu L, Suswam E, Zheng L, King PH., Free PMC Article | 02/16/2013 |
| We have identified a post-transcriptional regulatory network active during mouse pituitary development in which the expression of the hormone alphaGSU is increased by let7b/c through downregulation of KSRP | Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP.
Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M., Free PMC Article | 01/5/2013 |
| data suggest that miR-27b targets KSRP and modulates iNOS mRNA stability following C. parvum infection, a process that may be relevant to the regulation of epithelial anti-microbial defense in general | miR-27b targets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection.
Zhou R, Gong AY, Eischeid AN, Chen XM., Free PMC Article | 11/17/2012 |
| PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis. | PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis.
Briata P, Lin WJ, Giovarelli M, Pasero M, Chou CF, Trabucchi M, Rosenfeld MG, Chen CY, Gherzi R., Free PMC Article | 06/9/2012 |
| function of KSRP in innate immunity by negatively regulating interferon production | Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection.
Lin WJ, Zheng X, Lin CC, Tsao J, Zhu X, Cody JJ, Coleman JM, Gherzi R, Luo M, Townes TM, Parker JN, Chen CY., Free PMC Article | 11/12/2011 |
| Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability. | Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA.
Bikkavilli RK, Malbon CC., Free PMC Article | 06/28/2010 |
| Both inhibition of miR-155 and KSRP knockdown enhance the LPS-induced expression of select inflammation mediators, and the effect of KSRP knockdown is reverted by mature miR-155 | LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages.
Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P, Gherzi R. | 01/21/2010 |
| In addition to the approximately 75-kDa KSRP, a approximately 52-kD KSRP, t-KSRP, is present in the cytoplasm of a subpopulation of germ cells. | A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cells.
Xu M, McCarrey JR, Hecht NB., Free PMC Article | 01/21/2010 |
| KSRP is misregulated in the absence of SMN, and this correlated with increased mRNA stability of its mRNA target, p21(cip1/waf1), in spinal cord of mild spinal muscular atrophy. | KH-type splicing regulatory protein interacts with survival motor neuron protein and is misregulated in spinal muscular atrophy.
Tadesse H, Deschênes-Furry J, Boisvenue S, Côté J. | 01/21/2010 |
| A set of transcripts that are targets of KSRP and whose expression is increased by PI3K-AKT activation. | Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling.
Ruggiero T, Trabucchi M, Ponassi M, Corte G, Chen CY, al-Haj L, Khabar KS, Briata P, Gherzi R., Free PMC Article | 01/21/2010 |