| A novel intramolecular negative regulation of mouse Jak3 activity by tyrosine 820. | A novel intramolecular negative regulation of mouse Jak3 activity by tyrosine 820.
Sekine Y, Kikkawa K, Witthuhn BA, Kashiwakura JI, Muromoto R, Kitai Y, Fujimuro M, Oritani K, Matsuda T. | 06/25/2022 |
| PHF6 and JAK3 mutations cooperate to drive T-cell acute lymphoblastic leukemia progression. | PHF6 and JAK3 mutations cooperate to drive T-cell acute lymphoblastic leukemia progression.
Yuan S, Wang X, Hou S, Guo T, Lan Y, Yang S, Zhao F, Gao J, Wang Y, Chu Y, Shi J, Cheng T, Yuan W., Free PMC Article | 02/19/2022 |
| Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata. | Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata.
Dai Z, Chen J, Chang Y, Christiano AM., Free PMC Article | 01/22/2022 |
| Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization-Brief Report. | Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization-Brief Report.
Wang YC, Cai D, Cui XB, Chuang YH, Fay WP, Chen SY., Free PMC Article | 08/14/2021 |
| Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice. | Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice.
Barcia Durán JG, Lu T, Houghton S, Geng F, Schreiner R, Xiang J, Rafii S, Redmond D, Lis R., Free PMC Article | 08/7/2021 |
| Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8(+) T Cells. | Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8(+) T Cells.
Lee GW, Lee SW, Kim J, Ju YJ, Kim HO, Yun CH, Cho JH., Free PMC Article | 07/3/2021 |
| Here we show that CRISPR/Cas9-mediated inactivation of Suz12 cooperates with mutant JAK3 to drive T-cell transformation and T-cell acute lymphoblastic leukemia development | Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia.
Broux M, Prieto C, Demeyer S, Vanden Bempt M, Alberti-Servera L, Lodewijckx I, Vandepoel R, Mentens N, Gielen O, Jacobs K, Geerdens E, Vicente C, de Bock CE, Cools J., Free PMC Article | 02/8/2020 |
| Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models. | Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models.
Rivera-Munoz P, Laurent AP, Siret A, Lopez CK, Ignacimouttou C, Cornejo MG, Bawa O, Rameau P, Bernard OA, Dessen P, Gilliland GD, Mercher T, Malinge S., Free PMC Article | 04/6/2019 |
| Blockade of JAK1-JAK3 accelerated, and selective inactivation of STAT3 decelerated differentiation of progenitor cells. | Particular Role of JAK/STAT3 Signaling in Functional Control of Mesenchymal Progenitor Cells.
Zyuz'kov GN, Udut EV, Miroshnichenko LA, Polyakova TY, Simanina EV, Stavrova LA, Chaikovskii AV, Agafonov VI, Borodulina EV, Timofeev MS, Zyuz'kova YN, Danilets MG, Zhdanov VV, Udut VV. | 08/11/2018 |
| Study investigated the effect of Jak3 signaling on differentiation from nestin progenitor cells using E13.5 spinal progenitor cell cultures. Results indicated that neuronal and microglial cell differentiation was regulated primarily by Jak3 signaling and the developing neurons and neurite outgrowth might also be regulated by Jak3-dependent microglial activity. | Jak kinase 3 signaling in microgliogenesis from the spinal nestin+ progenitors in both development and response to injury.
Barua S, Chung JI, Kim AY, Lee SY, Lee SH, Baik EJ., Free PMC Article | 05/5/2018 |
| Small-scale in vivo screening identified several genes, including Cd109, that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 as a critical, pharmacologically targetable effector of CD109-driven lung cancer metastasis | Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis.
Chuang CH, Greenside PG, Rogers ZN, Brady JJ, Yang D, Ma RK, Caswell DR, Chiou SH, Winters AF, Grüner BM, Ramaswami G, Spencley AL, Kopecky KE, Sayles LC, Sweet-Cordero EA, Li JB, Kundaje A, Winslow MM., Free PMC Article | 08/12/2017 |
| a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported. | Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases.
Springuel L, Losdyck E, Saussoy P, Turcq B, Mahon FX, Knoops L, Renauld JC., Free PMC Article | 08/5/2017 |
| JAK1, JAK2, and JAK3 are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor. | Involvement of JAK1, JAK2, and JAK3 in Stimulation of Functional Activity of Mesenchymal Progenitor Cells by Fibroblast Growth Factor.
Zyuz'kov GN, Zhdanov VV, Udut EV, Miroshnichenko LA, Simanina EV, Polyakova TY, Stavrova LA, Udut VV, Minakova MY, Dygai AM. | 02/18/2017 |
| JAK mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells. | Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro.
Zyuz'kov GN, Zhdanov VV, Udut EV, Miroshnichenko LA, Simanina EV, Polyakova TY, Chaikovskii AV, Stavrova LA, Udut VV, Agafonov VI, Burmina YV, Danilets MG, Minakova MY, Dygai AM. | 02/18/2017 |
| JAK3 up-regulates SGLT1 activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response. | Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes.
Bhavsar SK, Singh Y, Sharma P, Khairnar V, Hosseinzadeh Z, Zhang S, Palmada M, Sabolic I, Koepsell H, Lang KS, Lang PA, Lang F. | 02/4/2017 |
| This study evaluated a chemical genetic toolkit that evaluated a biphasic requirement for JAK3 kinase activity in IL-2-driven T cell proliferation. | Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling.
Smith GA, Uchida K, Weiss A, Taunton J., Free PMC Article | 09/3/2016 |
| Experiments implicate JAK1/3 signaling in cancer- and myocardial infarction-mediated diaphragm weakness in mice. | Janus kinase inhibition prevents cancer- and myocardial infarction-mediated diaphragm muscle weakness in mice.
Smith IJ, Roberts B, Beharry A, Godinez GL, Payan DG, Kinsella TM, Judge AR, Ferreira LF., Free PMC Article | 09/3/2016 |
| Foxp3 has a rapid turn over in Treg partly controlled at the transcriptional level by the JAK/STAT pathway | Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.
Goldstein JD, Burlion A, Zaragoza B, Sendeyo K, Polansky JK, Huehn J, Piaggio E, Salomon BL, Marodon G., Free PMC Article | 08/27/2016 |
| JAK3 contributes to the regulation of membrane Kv1.5 protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase activity. | Regulation of Voltage-Gated K+ Channel Kv1.5 by the Janus Kinase JAK3.
Warsi J, Elvira B, Bissinger R, Hosseinzadeh Z, Lang F. | 08/20/2016 |
| JAK3 deficiency is followed by down-regulation of cytosolic Ca(2+) release, receptor and store operated Ca(2+) entry and Na(+)/Ca(2+) exchanger activity in dendritic cells. | Impact of Janus Kinase 3 on Cellular Ca Release, Store Operated Ca(2+) Entry and Na(+)/Ca(2+) Exchanger Activity in Dendritic Cells.
Yan J, Schmid E, Hosseinzadeh Z, Honisch S, Shumilina E, Fuchs J, Lang F. | 05/28/2016 |
| Jak3 has a role in promoting mucosal tolerance through suppressed expression and limiting activation of TLRs thereby preventing intestinal and systemic chronic low-grade inflammation and associated obesity and MetS | Role of Janus Kinase 3 in Predisposition to Obesity-associated Metabolic Syndrome.
Mishra J, Verma RK, Alpini G, Meng F, Kumar N., Free PMC Article | 04/23/2016 |
| Our results demonstrate that JAK3/STAT6 has an important role in bone marrow-derived fibroblast activation, extracellular matrix production, and interstitial fibrosis development. | JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis.
Yan J, Zhang Z, Yang J, Mitch WE, Wang Y., Free PMC Article | 04/2/2016 |
| results showed that different JAK3 mutations induce constitutive activation through distinct mechanisms, pointing to specific therapeutic perspectives | Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities.
Losdyck E, Hornakova T, Springuel L, Degryse S, Gielen O, Cools J, Constantinescu SN, Flex E, Tartaglia M, Renauld JC, Knoops L., Free PMC Article | 03/19/2016 |
| JAK3 down-regulates Na(+)/K(+)-ATPase activity, an effect involving gene expression and profoundly curtailing ATP consumption. | The Role of Janus Kinase 3 in the Regulation of Na⁺/K⁺ ATPase under Energy Depletion.
Hosseinzadeh Z, Honisch S, Schmid E, Jilani K, Szteyn K, Bhavsar S, Singh Y, Palmada M, Umbach AT, Shumilina E, Lang F. | 02/27/2016 |
| In conclusion, JAK3 deficiency leads to increased formation of calcitriol, which contributes to or even accounts for increased release of FGF23 and enhanced intestinal phosphate absorption. | Janus kinase 3 regulates renal 25-hydroxyvitamin D 1α-hydroxylase expression, calcitriol formation, and phosphate metabolism.
Umbach AT, Zhang B, Daniel C, Fajol A, Velic A, Hosseinzadeh Z, Bhavsar SK, Bock CT, Kandolf R, Pichler BJ, Amann KU, Föller M, Lang F. | 02/20/2016 |