| Regulation of 20alpha-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo. | Regulation of 20α-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo.
Paul M, Barreda AP, Gregson A, Kahl R, King M, Hussein WM, Walker FR, Smith R, Zakar T, Paul JW., Free PMC Article | 01/17/2024 |
| AKR1C1 and hormone metabolism in lipedema pathogenesis: a computational biology approach. | AKR1C1 and hormone metabolism in lipedema pathogenesis: a computational biology approach.
Kaftalli J, Bonetti G, Marceddu G, Dhuli K, Maltese PE, Donato K, Herbst KL, Michelini S, Chiurazzi P, Hill M, Michelini S, Michelini S, Bernini A, Bertelli M. | 12/29/2023 |
| 20alpha-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index. | 20α-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index.
Paul M, Zakar T, Phung J, Gregson A, Barreda AP, Butler TA, Walker FR, Pennell C, Smith R, Paul JW., Free PMC Article | 07/21/2023 |
| AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye. | AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye.
Zuo X, Zeng H, Wang B, Yang X, He D, Wang L, Ouyang H, Yuan J., Free PMC Article | 09/17/2022 |
| Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death. | Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death.
Phoo NLL, Dejkriengkraikul P, Khaw-On P, Yodkeeree S., Free PMC Article | 12/18/2021 |
| Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor. | Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor.
Liu X, Lian X, Liu X, Du Y, Zhu Y, Hu M, Zhang P, Liu Y, Zhou Y., Free PMC Article | 07/24/2021 |
| AKR1C1 Contributes to Cervical Cancer Progression via Regulating TWIST1 Expression. | AKR1C1 Contributes to Cervical Cancer Progression via Regulating TWIST1 Expression.
Wei X, Wei Z, Li Y, Tan Z, Lin C. | 07/10/2021 |
| Loss of AKR1C1 is a good prognostic factor in advanced NPC cases and increases chemosensitivity to cisplatin in NPC cells. | Loss of AKR1C1 is a good prognostic factor in advanced NPC cases and increases chemosensitivity to cisplatin in NPC cells.
Zhou C, Shen G, Yang F, Duan J, Wu Z, Yang M, Liu Y, Du X, Zhang X, Xiao S., Free PMC Article | 05/1/2021 |
| The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer. | The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer.
Zhu H, Hu Y, Zeng C, Chang L, Ge F, Wang W, Yan F, Zhao Q, Cao J, Ying M, Gu Y, Zheng L, He Q, Yang B., Free PMC Article | 04/17/2021 |
| Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema. | Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema.
Michelini S, Chiurazzi P, Marino V, Dell'Orco D, Manara E, Baglivo M, Fiorentino A, Maltese PE, Pinelli M, Herbst KL, Dautaj A, Bertelli M., Free PMC Article | 02/27/2021 |
| Use of AKR1C1 and TKTL1 in the Diagnosis of Low-grade Squamous Intraepithelial Lesions from Mexican Women. | Use of AKR1C1 and TKTL1 in the Diagnosis of Low-grade Squamous Intraepithelial Lesions from Mexican Women.
Sequeda-JuÁrez A, JimÉnez A, Espinosa-Montesinos A, Del Carmen Cardenas-Aguayo M, RamÓn-Gallegos E. | 11/21/2020 |
| Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis. | Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.
Gagliardi M, Cotella D, Santoro C, Corà D, Barlev NA, Piacentini M, Corazzari M., Free PMC Article | 09/5/2020 |
| Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids. | Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C(19)-steroids.
Endo S, Morikawa Y, Kudo Y, Suenami K, Matsunaga T, Ikari A, Hara A. | 08/15/2020 |
| AKR1C1 is a crucial regulator for cisplatin-resistance in HNSCC and also poor prognostic marker for patients. Targeting the AKR1C1-STAT axis may provide a new therapeutic strategy to treat patients who are refractory to cisplatin treatment. | AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway.
Chang WM, Chang YC, Yang YC, Lin SK, Chang PM, Hsiao M., Free PMC Article | 12/7/2019 |
| OPSCC with integrated HPV16 show upregulation of AKR1C1 and AKR1C3 expression. | Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis.
Huebbers CU, Verhees F, Poluschkin L, Olthof NC, Kolligs J, Siefer OG, Henfling M, Ramaekers FCS, Preuss SF, Beutner D, Seehawer J, Drebber U, Korkmaz Y, Lam WL, Vucic EA, Kremer B, Klussmann JP, Speel EM. | 08/10/2019 |
| AKR1C1 activates STAT3 pathway to promote NSCLC metastasis. | AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer.
Zhu H, Chang LL, Yan FJ, Hu Y, Zeng CM, Zhou TY, Yuan T, Ying MD, Cao J, He QJ, Yang B., Free PMC Article | 12/22/2018 |
| Decreased invasion caused by AKR1C1 knockdown suggests a novel role of AKR1C1 in cancer invasion, which is probably due to the regulation of Rac1, Src, or Akt. An inflammatory cytokine, interleukin-1beta, was found to increase AKR1C1 in bladder cancer cell lines. | Aldo-keto reductase 1C1 induced by interleukin-1β mediates the invasive potential and drug resistance of metastatic bladder cancer cells.
Matsumoto R, Tsuda M, Yoshida K, Tanino M, Kimura T, Nishihara H, Abe T, Shinohara N, Nonomura K, Tanaka S., Free PMC Article | 06/16/2018 |
| Data show that increased levels of AKR1C1/C2 enhanced the sensitivity of esophageal squamous cell carcinoma (ESCC) cells to ethyl-3,4-dihydroxybenzoate (EDHB). | The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death.
Li W, Hou G, Zhou D, Lou X, Xu Y, Liu S, Zhao X., Free PMC Article | 12/9/2017 |
| the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells. | Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Shiiba M, Yamagami H, Yamamoto A, Minakawa Y, Okamoto A, Kasamatsu A, Sakamoto Y, Uzawa K, Takiguchi Y, Tanzawa H. | 04/22/2017 |
| Activation of AKR1C1/ERbeta induces apoptosis by downregulation of c-FLIP in prostate cancer cells. | Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity.
Yun H, Xie J, Olumi AF, Ghosh R, Kumar AP., Free PMC Article | 03/5/2016 |
| results suggest a gender-specific modulatory effect of AKR1C1 on anxiety levels, most likely through changes in progesterone and allopregnanolone levels within and outside the brain | Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety?
Quast C, Reif A, Brückl T, Pfister H, Weber H, Mattheisen M, Cichon S, Lang T, Hamm A, Fehm L, Ströhle A, Arolt V, Domschke K, Kircher T, Wittchen HU, Pauli P, Gerlach AL, Alpers GW, Deckert J, Rupprecht R, Binder EB, Erhardt A. | 06/20/2015 |
| Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency. | Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.
Rižner TL, Penning TM., Free PMC Article | 08/30/2014 |
| activation of the Nrf2/AKR1C axis may contribute to oxaliplatin resistance in gastric carcinoma | Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification.
Chen CC, Chu CB, Liu KJ, Huang CY, Chang JY, Pan WY, Chen HH, Cheng YH, Lee KD, Chen MF, Kuo CC, Chen LT. | 12/21/2013 |
| The involvement of up-regulated AKR1C1, AKR1C3 and proteasome in CDDP resistance of colon cancers. | Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers.
Matsunaga T, Hojo A, Yamane Y, Endo S, El-Kabbani O, Hara A. | 08/10/2013 |
| Which promoted significant reduction of AKR1C1 and AKR1C2 expression. | Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line.
Beranič N, Lanišnik Rižner T. | 08/10/2013 |