| Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion. | Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion.
Faraldo MM, Romagnoli M, Wallon L, Dubus P, Deugnier MA, Fre S., Free PMC Article | 06/12/2024 |
| Targeted m[6]A demethylation of ITGA6 mRNA by a multisite dCasRx-m[6]A editor inhibits bladder cancer development. | Targeted m(6)A demethylation of ITGA6 mRNA by a multisite dCasRx-m(6)A editor inhibits bladder cancer development.
Ying X, Huang Y, Liu B, Hu W, Ji D, Chen C, Zhang H, Liang Y, Lv Y, Ji W., Free PMC Article | 02/2/2024 |
| miR-30a-5p targets ITGA6 to inhibit oral squamous cell carcinoma progression. | miR-30a-5p targets ITGA6 to inhibit oral squamous cell carcinoma progression.
Zhang G, Wang H, Liu G, Huang J. | 01/29/2024 |
| Evaluation of CD49f as a novel surface marker to identify functional adipose-derived mesenchymal stem cell subset. | Evaluation of CD49f as a novel surface marker to identify functional adipose-derived mesenchymal stem cell subset.
Zha K, Li X, Tian G, Yang Z, Sun Z, Yang Y, Wei F, Huang B, Jiang S, Li H, Sui X, Liu S, Guo Q., Free PMC Article | 05/15/2021 |
| Integrin alpha6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. | Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia.
Gang EJ, Kim HN, Hsieh YT, Ruan Y, Ogana HA, Lee S, Pham J, Geng H, Park E, Klemm L, Willman CL, Carroll WL, Mittelman SD, Orgel E, Oberley MJ, Parekh C, Abdel-Azim H, Bhojwani D, Wayne AS, De Arcangelis A, Georges-Labouesse E, Wayner E, Bonig H, Minasyan A, Ten Hoeve J, Graeber TG, Müschen M, Heisterkamp N, Kim YM., Free PMC Article | 02/27/2021 |
| During wound healing (WH), alpha6 integrin significantly increased in migratory cells and migration was coupled with differentiation | Dynamic expression of α6 integrin indicates epidermal cell behaviors.
He W, Xu H, Zhang Q, Zheng Y. | 07/4/2020 |
| The study shows that ITGA3 and ITGA6 promote distinct functions and signaling by collecting duct cells on laminin substrata. | The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth.
Yazlovitskaya EM, Viquez OM, Tu T, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Pozzi A, Zent R., Free PMC Article | 08/3/2019 |
| These data indicate that integrin alpha6beta4 and PMP22 cooperate to organize the internode and to allow proper propagation of the axonal signal along the axons. | A dual role for Integrin α6β4 in modulating hereditary neuropathy with liability to pressure palsies.
Poitelon Y, Matafora V, Silvestri N, Zambroni D, McGarry C, Serghany N, Rush T, Vizzuso D, Court FA, Bachi A, Wrabetz L, Feltri ML., Free PMC Article | 05/11/2019 |
| miR-542-5p attenuates fibroblast activation by targeting ITGA6 in silica-induced pulmonary fibrosis. | miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin α6 in Silica-Induced Pulmonary Fibrosis.
Yuan J, Li P, Pan H, Li Y, Xu Q, Xu T, Ji X, Liu Y, Yao W, Han L, Ni C., Free PMC Article | 03/9/2019 |
| alpha6 and beta1 integrins are induced in Schwann cells in the sciatic nerve after a crush injury, and the blocking of integrin activity by siRNA expression and by treatment with anti-integrin antibodies attenuates Schwann cell contact with cultured neurons and decreases neurite outgrowth. After nerve transection, the levels of alpha6 and beta1 integrins in the distal nerve stump are lower than corresponding nerve area... | α6 and β1 Integrin Heterodimer Mediates Schwann Cell Interactions with Axons and Facilitates Axonal Regeneration after Peripheral Nerve Injury.
Chang IA, Kim KJ, Namgung U. | 12/22/2018 |
| CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities. | CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities.
Song J, Ding F, Li S, Li W, Li N, Xue K. | 12/1/2018 |
| alpha6-integrin is a matrix stiffness-regulated mechanosensitive molecule which confers an invasive fibroblast phenotype and mediates experimental lung fibrosis. | Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis.
Chen H, Qu J, Huang X, Kurundkar A, Zhu L, Yang N, Venado A, Ding Q, Liu G, Antony VB, Thannickal VJ, Zhou Y., Free PMC Article | 09/1/2018 |
| our data suggest that alpha6beta4 integrin upregulation is an inducible protective mechanism that stabilizes the blood-brain barrier during neuroinflammatory conditions. | Endothelial α6β4 integrin protects during experimental autoimmune encephalomyelitis-induced neuroinflammation by maintaining vascular integrity and tight junction protein expression.
Welser JV, Halder SK, Kant R, Boroujerdi A, Milner R., Free PMC Article | 07/28/2018 |
| he potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway. | Netrin-1-Induced Stem Cell Bioactivity Contributes to the Regeneration of Injured Tissues via the Lipid Raft-Dependent Integrin α6β4 Signaling Pathway.
Lee SS, Lee SJ, Lee SH, Ryu JM, Lim HS, Kim JS, Song EJ, Jung YH, Lee HJ, Kim CH, Han HJ., Free PMC Article | 05/26/2018 |
| RFX1 transcriptionally targets Itga6 in Sertoli cells, thereby, helping maintain the integrity of the basal lamina during testis cord development. | RFX1 maintains testis cord integrity by regulating the expression of Itga6 in male mouse embryos.
Wang B, Qi T, Chen SQ, Ye L, Huang ZS, Li H. | 01/27/2018 |
| pericyte alpha6beta1-integrin regulates tumour blood vessels by both controlling PDGFRbeta and basement membrane architecture. | Dual role of pericyte α6β1-integrin in tumour blood vessels.
Reynolds LE, D'Amico G, Lechertier T, Papachristodoulou A, Muñoz-Félix JM, De Arcangelis A, Baker M, Serrels B, Hodivala-Dilke KM., Free PMC Article | 01/27/2018 |
| ITGA6 maintains structural integrity of the kidney collecting system. | Integrin alpha6 maintains the structural integrity of the kidney collecting system.
Viquez OM, Yazlovitskaya EM, Tu T, Mernaugh G, Secades P, McKee KK, Georges-Labouesse E, De Arcangelis A, Quaranta V, Yurchenco P, Gewin LC, Sonnenberg A, Pozzi A, Zent R., Free PMC Article | 01/6/2018 |
| Integrin alpha 6 Expression on Microglia Surface and Motility on Laminin Is Up-regulated upon Adenosine Diphosphate Stimulation. | Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin.
Lee SH, Sud N, Lee N, Subramaniyam S, Chung CY., Free PMC Article | 06/3/2017 |
| Ahr ligand aminoflavone targets breast cancer cells with stem cell-like properties, at least in part by abolishing alpha6-integrin expression. | AhR ligand Aminoflavone inhibits α6-integrin expression and breast cancer sphere-initiating capacity.
Brantley E, Callero MA, Berardi DE, Campbell P, Rowland L, Zylstra D, Amis L, Yee M, Simian M, Todaro L, Loaiza-Perez AI, Soto U. | 02/18/2017 |
| interaction of alpha6beta1 in embryonic stem cells (ECCs) with laminin-1 activates alpha6beta1/CD151 signaling which programs ESCs toward the endothelial cells lineage fate | Integrin α6β1 Expressed in ESCs Instructs the Differentiation to Endothelial Cells.
Toya SP, Wary KK, Mittal M, Li F, Toth PT, Park C, Rehman J, Malik AB., Free PMC Article | 03/19/2016 |
| Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions. | Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains.
Kobayashi M, Ohno T, Ihara K, Murai A, Kumazawa M, Hoshino H, Iwanaga K, Iwai H, Hamana Y, Ito M, Ohno K, Horio F., Free PMC Article | 07/4/2015 |
| Immunohistological analysis of the tumors showed that Tie2-dependent a6 gene deletion was associated with reduced tumor vascularization and with reduced infiltration of proangiogenic Tie2-expressing macrophages | Tie2-dependent deletion of α6 integrin subunit in mice reduces tumor growth and angiogenesis.
Bouvard C, Segaoula Z, De Arcangelis A, Galy-Fauroux I, Mauge L, Fischer AM, Georges-Labouesse E, Helley D. | 05/30/2015 |
| CD29 and CD49f have a critical role of in mediating cancer metastasis. | A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating cells isolated from a Brca1-associated mouse model of breast cancer.
Vassilopoulos A, Chisholm C, Lahusen T, Zheng H, Deng CX. | 05/2/2015 |
| NLGN1 and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 deletion causes an aberrant VE-cadherin, laminin and alpha6 integrin distribution in vessels | Neuroligin 1 induces blood vessel maturation by cooperating with the α6 integrin.
Samarelli AV, Riccitelli E, Bizzozero L, Silveira TN, Seano G, Pergolizzi M, Vitagliano G, Cascone I, Carpentier G, Bottos A, Primo L, Bussolino F, Arese M., Free PMC Article | 10/4/2014 |
| alpha6 integrin is an essential upstream regulator of the IGF-1R survival pathway that regulates the activity level of caspase-3 for it to signal differentiation initiation of lens epithelial cells. | α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.
Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS., Free PMC Article | 05/3/2014 |