| Potential Mechanism of Platelet GPIIb/IIIa and Fibrinogen on Retinal Vein Occlusion. | Potential Mechanism of Platelet GPIIb/IIIa and Fibrinogen on Retinal Vein Occlusion.
Ren H, Sun Y, Li Y, Yuan X, Jiang B, Zhang W, Liu G, Lu P. | 07/15/2024 |
| SHIP1 Controls Internal Platelet Contraction and alphaIIbbeta3 Integrin Dynamics in Early Platelet Activation. | SHIP1 Controls Internal Platelet Contraction and α(IIb)β(3) Integrin Dynamics in Early Platelet Activation.
Severin S, Consonni A, Chicanne G, Allart S, Payrastre B, Gratacap MP., Free PMC Article | 01/28/2023 |
| [Effects of the ITGA2B Nonsense Mutation (c.2659C > T, p.Q887X) on Platelet Function in a Mouse Model of Glanzmann's Thrombasthenia Generated with CRISPR/Cas9 Technology]. | [Effects of the ITGA2B Nonsense Mutation (c.2659C > T, p.Q887X) on Platelet Function in a Mouse Model of Glanzmann's Thrombasthenia Generated with CRISPR/Cas9 Technology].
Yang F, Jiang M, Lin ZH, Xie ZL, Ma ZN, Yang L, Liu H, Wang ZY, Zhou L. | 04/23/2022 |
| Nonsense-mediated mRNA decay efficiency influences bleeding severity in ITGA2B c.2659C > T (p.Q887X) knock-in mice. | Nonsense-mediated mRNA decay efficiency influences bleeding severity in ITGA2B c.2659C > T (p.Q887X) knock-in mice.
Xie Z, Jiang J, Cao L, Jiang M, Yang F, Ma Z, Wang Z, Ruan C, Liu H, Zhou L. | 01/1/2022 |
| Knock-in mice bearing constitutively active alphaIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction. | Knock-in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction.
Akuta K, Kiyomizu K, Kashiwagi H, Kunishima S, Nishiura N, Banno F, Kokame K, Kato H, Kanakura Y, Miyata T, Tomiyama Y. | 06/19/2021 |
| Mimic chronic immune thrombocytopaenia using murine platelet induced model through immunized CD41-knockout mice. | Novel Murine Model of Immune Thrombocytopaenia through Immunized CD41 Knockout Mice.
Li X, Wang SW, Feng Q, Hou Y, Lu N, Ma CH, Gao CJ, Hou M, Peng J. | 07/13/2019 |
| alphaIIb beta3 antagonist TMV-7/trimucrin prevents thrombosis with causing Fc receptor gamma-chain IIa-mediated thrombocytopenia. | An α(II)(b) β(3) antagonist prevents thrombosis without causing Fc receptor γ-chain IIa-mediated thrombocytopenia.
Kuo YJ, Chen YR, Hsu CC, Peng HC, Huang TF. | 07/7/2018 |
| Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin. | Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin.
Gao J, Huang M, Lai J, Mao K, Sun P, Cao Z, Hu Y, Zhang Y, Schulte ML, Jin C, Wang J, White GC, Xu Z, Ma YQ., Free PMC Article | 06/16/2018 |
| Platelets from Dok-1-/- mice displayed normal aggregation, activation of integrin alphaIIbbeta3, P-selectin surface expression, and soluble fibrinogen binding. These findings indicate that Dok-1 does not affect "inside-out" platelet signalling. | Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.
Niki M, Nayak MK, Jin H, Bhasin N, Plow EF, Pandolfi PP, Rothman PB, Chauhan AK, Lentz SR., Free PMC Article | 01/6/2018 |
| platelets clearly support early steps in pulmonary metastasis via GPIIb-dependent formation of platelet-tumor-aggregates | Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis.
Echtler K, Konrad I, Lorenz M, Schneider S, Hofmaier S, Plenagl F, Stark K, Czermak T, Tirniceriu A, Eichhorn M, Walch A, Enders G, Massberg S, Schulz C., Free PMC Article | 08/26/2017 |
| ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals. | Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL.
Cordeiro OG, Chypre M, Brouard N, Rauber S, Alloush F, Romera-Hernandez M, Bénézech C, Li Z, Eckly A, Coles MC, Rot A, Yagita H, Léon C, Ludewig B, Cupedo T, Lanza F, Mueller CG., Free PMC Article | 08/13/2016 |
| Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. | Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.
Nishikawa S, Arai S, Masamoto Y, Kagoya Y, Toya T, Watanabe-Okochi N, Kurokawa M. | 02/14/2015 |
| Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation. | Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.
Xu Z, Chen X, Zhi H, Gao J, Bialkowska K, Byzova TV, Pluskota E, White GC 2nd, Liu J, Plow EF, Ma YQ., Free PMC Article | 10/25/2014 |
| ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding. | ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.
Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ., Free PMC Article | 07/19/2014 |
| reduction of talin-beta3 integrin binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding | A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.
Stefanini L, Ye F, Snider AK, Sarabakhsh K, Piatt R, Paul DS, Bergmeier W, Petrich BG., Free PMC Article | 06/14/2014 |
| deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation. | Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice.
Hughan SC, Spring CM, Schoenwaelder SM, Sturgeon S, Alwis I, Yuan Y, McFadyen JD, Westein E, Goddard D, Ono A, Yamanashi Y, Nesbitt WS, Jackson SP., Free PMC Article | 04/26/2014 |
| Platelets lacking ERp57 have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57, implicating surface ERp57 in platelet aggregation. | Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin.
Wang L, Wu Y, Zhou J, Ahmad SS, Mutus B, Garbi N, Hämmerling G, Liu J, Essex DW., Free PMC Article | 01/25/2014 |
| Data indicate that Pyk2 is a common signaling effector downstream of both G12/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation. | Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets.
Kim S, Cipolla L, Guidetti G, Okigaki M, Jin J, Torti M, Kunapuli SP., Free PMC Article | 09/7/2013 |
| These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen. | The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.
Cipolla L, Consonni A, Guidetti G, Canobbio I, Okigaki M, Falasca M, Ciraolo E, Hirsch E, Balduini C, Torti M. | 08/31/2013 |
| Here we show that platelet integrin CD41 (alphaIIb), currently thought to only transiently mark fetal hematopoietic stem cells, is expressed on an adult subtype that accumulates with age. | CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age.
Gekas C, Graf T. | 08/3/2013 |
| identified Hic-5 as a novel and specific regulatory factor for thrombin-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice. | Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation and platelet aggregation in mice.
Kim-Kaneyama JR, Miyauchi A, Lei XF, Arita S, Mino T, Takeda N, Kou K, Eto K, Yoshida T, Miyazaki T, Shioda S, Miyazaki A. | 02/9/2013 |
| These results suggested that platelet associated anti-alphaIIbbeta3 antibodies in primary primary immune thrombocytopenia tended to recognize highly restricted regions of alphaIIb with clonality. | Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia.
Kiyomizu K, Kashiwagi H, Nakazawa T, Tadokoro S, Honda S, Kanakura Y, Tomiyama Y. | 11/3/2012 |
| Impaired spreading on fibrinogen and clot retraction with normal levels of alpha(IIb)beta(3) was observed in Lgals1(-/-) platelets, indicating a failure in the "outside-in" signaling through this integrin. | Binding of galectin-1 to αIIbβ₃ integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis.
Romaniuk MA, Croci DO, Lapponi MJ, Tribulatti MV, Negrotto S, Poirier F, Campetella O, Rabinovich GA, Schattner M. | 09/22/2012 |
| Glycoprotein IIb/IIIa-targeted microbubbles specifically bind to activated platelets in vitro, allowing real-time molecular imaging of acute arterial thrombosis in a mouse model. | Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice.
Wang X, Hagemeyer CE, Hohmann JD, Leitner E, Armstrong PC, Jia F, Olschewski M, Needles A, Peter K, Ahrens I. | 09/8/2012 |
| Data indicate that the inflammatory cytokines TNF-alpha and IL-1 could be key components of the endothelial cell (EC) response and alphaIIb-beta3 integrin in platelets was required for late-phase thrombus stability. | In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.
Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich BG, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R., Free PMC Article | 05/26/2012 |