| Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2. | Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2.
Chaudhary JK, Ahamad N, Rath PC. | 01/16/2024 |
| Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury. | Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury.
He T, Yang L, Wu D. | 07/2/2022 |
| IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis. | IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.
Li Y, Wang Y, Guo H, Wu Q, Hu Y., Free PMC Article | 03/12/2022 |
| IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-kappaB/NFATc1 signaling. | IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling.
Kim I, Kim JH, Kim K, Seong S, Lee KB, Kim N., Free PMC Article | 01/29/2022 |
| IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. | IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon.
Minamide K, Sato T, Nakanishi Y, Ohno H, Kato T, Asano J, Ohteki T., Free PMC Article | 03/6/2021 |
| Data show that interferon regulatory factor 2 (IRF2), a member of the interferon regulatory factor (IRF) family of transcription factors, was essential for the transcriptional activation of gasdermin-D (GSDMD). | IRF2 transcriptionally induces GSDMD expression for pyroptosis.
Kayagaki N, Lee BL, Stowe IB, Kornfeld OS, O'Rourke K, Mirrashidi KM, Haley B, Watanabe C, Roose-Girma M, Modrusan Z, Kummerfeld S, Reja R, Zhang Y, Cho V, Andrews TD, Morris LX, Goodnow CC, Bertram EM, Dixit VM. | 07/4/2020 |
| The results point to a unique, cell-type selective role for IRF-2 in Innate lymphoid cells (ILC) development, acting at a discrete step critical for the generation of functionally competent Innate lymphoid cells precursors (ILCPs). | Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2.
Okubo Y, Tokumaru S, Yamamoto Y, Miyagawa SI, Sanjo H, Taki S. | 04/11/2020 |
| The KRAS( *)-IRF2-CXCL3-CXCR2 axis drives colorectal cancer cell immune suppression and resistance to anti-PD-1 immunotherapy. | KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, Li J, Wang G, Lan Z, Li J, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, Korphaisarn K, Chakravarti D, Chang A, Spring DJ, Chang Q, Zhang J, Maru DM, Maeda DY, Zebala JA, Kopetz S, Wang YA, DePinho RA., Free PMC Article | 02/8/2020 |
| our data suggest that IRF2 is an important regulator of the proinflammatory response in macrophages by controlling HIF-1alpha-dependent glycolytic gene expression and glycolysis. | IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages.
Cui H, Banerjee S, Guo S, Xie N, Liu G., Free PMC Article | 04/13/2019 |
| Data show that HCFC2 is a critical component of the IRF1 and IRF2 transcriptional machinery that regulates Tlr3 gene expression. | HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.
Sun L, Jiang Z, Acosta-Rodriguez VA, Berger M, Du X, Choi JH, Wang J, Wang KW, Kilaru GK, Mohawk JA, Quan J, Scott L, Hildebrand S, Li X, Tang M, Zhan X, Murray AR, La Vine D, Moresco EMY, Takahashi JS, Beutler B., Free PMC Article | 12/9/2017 |
| Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis. | Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte development.
Huang XF, Nandakumar V, Tumurkhuu G, Wang T, Jiang X, Hong B, Jones L, Won H, Yoshii H, Ozato K, Masumi A, Chen SY., Free PMC Article | 09/23/2017 |
| Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion | Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion.
Li MM, Bozzacco L, Hoffmann HH, Breton G, Loschko J, Xiao JW, Monette S, Rice CM, MacDonald MR., Free PMC Article | 07/22/2017 |
| Chimeric IRF-2 binds with IRF-E motif and VREbeta but not with VREalpha1. | Chimeric murine interferon regulatory factor-2 (IRF-2) binds to IRF-E (IRF binding element), VREβ (virus response element) but not to VREα1.
Prakash K, Kumar P, Mukherjee S, Rath PC. | 10/10/2015 |
| These results revealed a multi-faceted role of IRF-2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR-dependent manner and antibody production via up-regulation of Blimp-1. | IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms.
Minamino K, Takahara K, Adachi T, Nagaoka K, Iyoda T, Taki S, Inaba K. | 01/26/2013 |
| In mice doubly deficient forIRF-2 and CD1d, the overall memory phenotype T cell population is contrastingly enlarged. | Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S. | 08/11/2012 |
| IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 | Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.
Hayashi H, Kohno T, Yasui K, Murota H, Kimura T, Duncan GS, Nakashima T, Yamamoto K, Katayama I, Ma Y, Chua KJ, Suematsu T, Shimokawa I, Akira S, Kubo Y, Mak TW, Matsuyama T., Free PMC Article | 08/6/2013 |
| IRF2 regulates exocytosis in pancreatic acinar cells; defects in this process might be involved in the early phases of acute pancreatitis. | Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells.
Mashima H, Sato T, Horie Y, Nakagawa Y, Kojima I, Ohteki T, Ohnishi H. | 11/26/2011 |
| IRF-2 plays an important role in megakaryopoiesis in inflammatory states. | Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells.
Masumi A, Hamaguchi I, Kuramitsu M, Mizukami T, Takizawa K, Momose H, Naito S, Yamaguchi K. | 01/21/2010 |
| Irf2-/- HSCs showed enhanced cell cycling status and failed to produce hematopoietic cells in competitive repopulation assays | Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion.
Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T. | 01/21/2010 |
| The involvement of IRF1 and IRF2 in TLR2-mediated responses, was studied. | Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-alpha production.
Liljeroos M, Vuolteenaho R, Rounioja S, Henriques-Normark B, Hallman M, Ojaniemi M. | 01/21/2010 |
| Together, these data demonstrate that IRF-2 is involved in the regulation of TR2 expression in EL-4 T cells. | Regulation of the murine TR2/HVEM gene expression by IRF.
Sul OJ, Lee HW, Kim WK, Choi JH, Kwak JS, Choi YJ, Latour AM, Koller BH, Jeong CS, Kwon BS. | 01/21/2010 |
| In the absence of IRF-2, uterine natural killer (uNK) cells are normal in number and function, but there is a serious deficiency of peripheral NK cells. | Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy.
Ashkar AA, Black GP, Wei Q, He H, Liang L, Head JR, Croy BA. | 01/21/2010 |
| IRF-2 is acetylated in a cell growth-dependent manner, which enables it to contribute to transcription of cell growth-regulated promoters | Interferon regulatory factor-2 regulates cell growth through its acetylation.
Masumi A, Yamakawa Y, Fukazawa H, Ozato K, Komuro K. | 01/21/2010 |
| Irf2 has an important role in vitro in the regulation of COX-2 expression by LPS. | The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS-induced cyclooxygenase-2 (COX-2) expression in vivo and in vitro.
Zhang S, Thomas K, Blanco JC, Salkowski CA, Vogel SN. | 01/21/2010 |
| Binding affinity of IRF-2 is similar to that of IRF-1 and B lymphocyte-induced maturation protein-1 (Blimp-1) for functionally important regulatory sites containing the consensus sequence GAAAG. | B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites.
Kuo TC, Calame KL. | 01/21/2010 |