| A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells. | A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells.
Giner XC, Pierre KJ, Robert NM, Tremblay JJ., Free PMC Article | 12/31/2022 |
| Results suggest that FEAT facilitates the INSL3 production in testicular Leydig cells that is essential for transabdominal testis migration. | FEAT enhances INSL3 expression in testicular Leydig cells.
Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A. | 01/26/2019 |
| The results displayed that INSL3 changed RXFP2 expression in mouse gubernaculum testis cells in vitro | An insight into insulin-like factor 3 regulate its receptor RXFP2 in mouse gubernaculum testis cells.
Duan S, Zhang X, Jiang X, Xie L, Sun Z, Ma S, Li J., Free PMC Article | 10/29/2016 |
| COUP-TFII cooperates with the nuclear receptor steroidogenic factor 1 (SF1) to further enhance Insl3 promoter activity in Leydig cells. | The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells.
Mendoza-Villarroel RE, Di-Luoffo M, Camiré E, Giner XC, Brousseau C, Tremblay JJ. | 10/31/2015 |
| Microarray expression profiling of whole adrenal mRNA from ovariectomized vs. intact mice demonstrated selective upregulation of gonadal-like genes including Spinlw1 and Insl3 in GDX-induced adrenocortical tumors of the mouse. | Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.
Schillebeeckx M, Pihlajoki M, Gretzinger E, Yang W, Thol F, Hiller T, Löbs AK, Röhrig T, Schrade A, Cochran R, Jay PY, Heikinheimo M, Mitra RD, Wilson DB., Free PMC Article | 08/8/2015 |
| Our data suggest that beta-catenin and NOTCH1 pathways are potential targets of INSL3 signaling during gubernacular development. | Mechanisms of INSL3 signaling in male reproductive organs.
Huang Z, Kaftanovskaya EM, Rivas B, Agoulnik AI. | 05/3/2014 |
| Data suggest that Insl3/Rxfp2 (insulin-like peptide 3/relaxin receptor 2) signaling is important for testicular descent; however, germ-cell deletion of Rxfp2 did not affect spermatogenesis, germ cell survival, or male fertility. | Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice.
Huang Z, Rivas B, Agoulnik AI., Free PMC Article | 05/18/2013 |
| beta-catenin and Notch pathways are potential targets of INSL3 signaling during gubernacular development. | Suppression of insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum development.
Kaftanovskaya EM, Feng S, Huang Z, Tan Y, Barbara AM, Kaur S, Truong A, Gorlov IP, Agoulnik AI., Free PMC Article | 04/16/2011 |
| INSL3 is a powerful and multifunctional promoter of tumor growth and angiogenesis in human thyroid cancer cell xenografts. INSL3 actions involve RXFP2 activation and the secretion of S100A4 and (pro-)cathepsin-L | INSL3 has tumor-promoting activity in thyroid cancer.
Hombach-Klonisch S, Bialek J, Radestock Y, Truong A, Agoulnik AI, Fiebig B, Willing C, Weber E, Hoang-Vu C, Klonisch T. | 07/12/2010 |
| Poorly formed gubernacula and increased testicular mobility in Insl3 mutant mice result in spermatic cord anomalies, delayed/absent testicular descent and subsequent testicular torsion in a gene dose dependent manner | Loss of Insl3: a potential predisposing factor for testicular torsion.
Sozubir S, Barber T, Wang Y, Ahn C, Zhang S, Verma S, Lonergan D, Lorenzo AJ, Nef S, Baker LA. | 06/14/2010 |
| INSL3 evidently traverses the blood-testis barrier to enter the seminiferous compartment, rete testis, and epididymis in sufficient concentration to be able to address the specific INSL3 receptors (RXFP2) on post-meiotic germ cells and in the epididymis. | Dynamics of INSL3 peptide expression in the rodent testis.
Anand-Ivell R, Heng K, Hafen B, Setchell B, Ivell R. | 01/21/2010 |
| Estradiol represses Insl3 expression in MA-10 Leydig cells. | Estradiol represses insulin-like 3 expression and promoter activity in MA-10 Leydig cells.
Laguë E, Tremblay JJ. | 01/21/2010 |
| Important new insights into the regulation of Insl3 transcription in Leydig cells and the mode of action of phthalates. | Antagonistic effects of testosterone and the endocrine disruptor mono-(2-ethylhexyl) phthalate on INSL3 transcription in Leydig cells.
Laguë E, Tremblay JJ. | 01/21/2010 |
| These results suggest that the downregulation of INSL3 mRNA by diethylhexyl phthalate might cause abnormalities of gubernacular development, which might be one of the mechanisms for development of cryptorchidism. | Effects of diethylhexyl phthalate (DEHP) on INSL3 mRNA expression by Leydig cells derived from mouse embryos and in newborn mice.
Song XF, Wei GH, Liu X, Zhang DY, Chen X, Deng YJ. | 01/21/2010 |
| Disruption of the Greatgene causes failure of the transabdominal phase of descent, identical to that seen in the Insl3-deficient mutants, consistent with the recent data suggesting that Great gene encodes the Insl3 transmembrane receptor. | Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.
Tomiyama H, Hutson JM, Truong A, Agoulnik AI. | 01/21/2010 |
| neither Insl3 nor Lgr8 contribute to the RLN signaling pathway; Insl3/Lgr8 and Rln1/Lgr7 actions do not overlap in vivo | Genetic targeting of relaxin and insulin-like factor 3 receptors in mice.
Kamat AA, Feng S, Bogatcheva NV, Truong A, Bishop CE, Agoulnik AI. | 01/21/2010 |
| Mutations in INSL3 might contribute to the etiology of cryptorchidism.I | GREAT/LGR8 is the only receptor for insulin-like 3 peptide.
Bogatcheva NV, Truong A, Feng S, Engel W, Adham IM, Agoulnik AI. | 01/21/2010 |
| overexpression of the insl3 in female mice causes descent of the ovaries | The overexpression of the insl3 in female mice causes descent of the ovaries.
Adham IM, Steding G, Thamm T, Büllesbach EE, Schwabe C, Paprotta I, Engel W. | 01/21/2010 |
| NR4A1 as an important regulator of mouse INSL3 promoter activity | The orphan nuclear receptor NR4A1 regulates insulin-like 3 gene transcription in Leydig cells.
Robert NM, Martin LJ, Tremblay JJ. | 01/21/2010 |
| Insl3/Lgr8 and Rln1/Lgr7 pathways are distinct and separate in vivo | Genetic targeting of relaxin and insl3 signaling in mice.
Feng S, Bogatcheva NV, Kamat AA, Agoulnik AI. | 01/21/2010 |
| Insl3 expression causes inguinal hernia in females; gubernaculum formation is the most sensitive biological response as regards Insl3 | Female mice carrying a ubiquitin promoter-Insl3 transgene have descended ovaries and inguinal hernias but normal fertility.
Koskimies P, Suvanto M, Nokkala E, Huhtaniemi IT, McLuskey A, Themmen AP, Poutanen M. | 01/21/2010 |