| Epistasis Between HLA-DRB1*16:02:01 and SLC16A11 T-C-G-T-T Reduces Odds for Type 2 Diabetes in Southwest American Indians. | Epistasis Between HLA-DRB1*16:02:01 and SLC16A11 T-C-G-T-T Reduces Odds for Type 2 Diabetes in Southwest American Indians.
Williams RC, Hanson RL, Peters B, Kearns K, Knowler WC, Bogardus C, Baier LJ., Free PMC Article | 09/6/2024 |
| Downregulation of SLC16A11 is Present in Offspring of Mothers with Gestational Diabetes. | Downregulation of SLC16A11 is Present in Offspring of Mothers with Gestational Diabetes.
Sevilla-Domingo M, Olivo-Ramirez CG, Huerta-Padilla VM, Gómez-Díaz RA, González-Carranza E, Acevedo-Rodriguez GE, Hernandez-Zuñiga VE, Gonzalez ALV, Mateos-Sanchez L, Mondragon-Gonzalez R, Garrido-Magaña EP, Ramirez-Garcia LA, Wacher NH, Vargas MS. | 08/13/2022 |
| Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population. | Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population.
Mardones L, Petermann-Rocha F, Martinez-Sanguinetti MA, Leiva AM, Troncoso-Pantoja C, Martorell M, Lasserre N, Ulloa N, Perez-Bravo F, Celis-Morales C, Villagran M, ELHOC group (Epidemiology of Lifestyle and Health Outcomes in Chile)., Free PMC Article | 11/22/2021 |
| The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes. | The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes.
Kimura Y, Higuchi I, Kobayashi M, Furugen A, Narumi K, Suzuki Y, Miyoshi H, Nakamura A, Atsumi T, Iseki K. | 10/23/2021 |
| Mouse model carrying the reconstituted T2D risk haplotype of human SLC16A11 displays elevated blood and liver triglycerides, glucose intolerance, insulin resistance, and increased levels of lipin 1 protein in the liver in response to a high-fat diet. Human LPIN1 levels are increased in HepG2 cells overexpressing the mutant SLC16A11. | Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q, Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q. | 06/14/2021 |
| The T2D risk haplotype in the SLC16A11 region includes a cis-eQTL that decreases SLC16A11 expression in a dose-dependent manner in liver tissue. | Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, MEDIA Consortium, SIGMA T2D Consortium, Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES, Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, MEDIA Consortium, SIGMA T2D Consortium, Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES., Free PMC Articles: PMC5562285, PMC5562285 | 06/14/2021 |
| Mouse model carrying the reconstituted T2D risk haplotype of SLC16A11 displays elevated blood and liver triglycerides, glucose intolerance, insulin resistance, and increased levels of lipin 1 protein in the liver in response to a high-fat diet. Human LPIN1 levels are increased in HepG2 cells overexpressing the mutant SLC16A11. | Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q, Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q. | 05/25/2021 |
| The previously reported effects of SLC16A11 variants shown to be associated with diabetes in Mexicans was replicated in a large Mexican-American sample, but these effects were not significant in five non-Mexican Hispanic/Latino groups sampled from U.S. populations. | Associations between SLC16A11 variants and diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Hidalgo BA, Sofer T, Qi Q, Schneiderman N, Chen YI, Kaplan RC, Avilés-Santa ML, North KE, Arnett DK, Szpiro A, Cai J, Yu B, Boerwinkle E, Papanicolaou G, Laurie CC, Rotter JI, Stilp AM., Free PMC Article | 08/12/2020 |
| Individuals carrying the SLC16A11 risk haplotype exhibited decreased insulin action. Higher serum ALT and GGT levels were found in carriers with type 2 diabetes, and larger adipocytes in subcutaneous fat in the size distribution in carrier women with normal weight. | The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes.
Almeda-Valdes P, Gómez Velasco DV, Arellano Campos O, Bello-Chavolla OY, Del Rocío Sevilla-González M, Viveros Ruiz T, Martagón Rosado AJ, Bautista CJ, Muñoz Hernandez L, Cruz-Bautista I, Moreno-Macias H, Huerta-Chagoya A, Rodríguez-Álvarez KG, Walford GA, Jacobs SBR, Guillen Pineda LE, Ordoñez-Sánchez ML, Roldan-Valadez E, Azpiroz J, Furuzawa-Carballeda J, Clark P, Herrera-Hernández MF, Zambrano E, Florez JC, Tusié Luna MT, Aguilar-Salinas CA. | 03/2/2019 |
| rs13342232 might be involved in the risk of pediatric-onset type 2 diabetes in Mexican families | Associations of common variants in the SLC16A11, TCF7L2, and ABCA1 genes with pediatric-onset type 2 diabetes and related glycemic traits in families: A case-control and case-parent trio study.
Miranda-Lora AL, Cruz M, Molina-Díaz M, Gutiérrez J, Flores-Huerta S, Klünder-Klünder M. | 07/14/2018 |
| Study demonstrates that disruption of SLC16A11 in primary human hepatocytes leads to Type 2 diabetes (T2D)-relevant changes in fatty acid and lipid metabolism; these results implicate reduced SLC16A11 function in liver as a causal factor for T2D. | Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, MEDIA Consortium, SIGMA T2D Consortium, Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES, Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, MEDIA Consortium, SIGMA T2D Consortium, Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES., Free PMC Articles: PMC5562285, PMC5562285 | 08/5/2017 |
| Our study identified an association between the SLC16A11 variant rs75493593 and type 2 diabetes in American Indians, where the effect on diabetes was much more pronounced in nonobese individuals. rs75493593 was also associated with RNASEK gene expression. | Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression.
Traurig M, Hanson RL, Marinelarena A, Kobes S, Piaggi P, Cole S, Curran JE, Blangero J, Göring H, Kumar S, Nelson RG, Howard BV, Knowler WC, Baier LJ, Bogardus C., Free PMC Article | 06/4/2016 |
| Genetic association studies show that common variants in ABCA1 and SLC16A11 are involved in type 2 diabetes (T2D) susceptibility. Particularly, the variants rs10811661 (CDKN2A/2B) and rs9282541 (ABCA1) are associated with T2D in adult Maya population. | Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4α, KCNJ11, PPARγ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes.
Lara-Riegos JC, Ortiz-López MG, Peña-Espinoza BI, Montúfar-Robles I, Peña-Rico MA, Sánchez-Pozos K, Granados-Silvestre MA, Menjivar M. | 07/4/2015 |
| Despite type 2 diabetes having been well studied by GWAS in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism. | Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
SIGMA Type 2 Diabetes Consortium, Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, García-Ortíz H, Gómez-Vázquez MJ, Burtt NP, Aguilar-Salinas CA, González-Villalpando C, Florez JC, Orozco L, Haiman CA, Tusié-Luna T, Altshuler D., Free PMC Article | 02/22/2014 |