| Integrin-Linked Kinase in the Development of Gastric Tumors Induced by Helicobacter pylori: Regulation and Prevention Potential. | Integrin-Linked Kinase in the Development of Gastric Tumors Induced by Helicobacter pylori: Regulation and Prevention Potential.
Li B, He J, Zhang R, Liu S, Zhang X, Li Z, Ma C, Wang W, Cui Y, Zhang Y. | 07/23/2024 |
| ILK inhibition reduces osteophyte formation through suppression of osteogenesis in BMSCs via Akt/GSK-3beta/beta-catenin pathway. | ILK inhibition reduces osteophyte formation through suppression of osteogenesis in BMSCs via Akt/GSK-3β/β-catenin pathway.
Huang Z, Huang L, Ding J, Huang Y, Huang X, Li T. | 03/19/2024 |
| Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis. | Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis.
Ahmed AU, Almasabi S, Firestein R, Williams BRG., Free PMC Article | 12/20/2023 |
| Mechanosensors control skeletal muscle mass, molecular clocks, and metabolism. | Mechanosensors control skeletal muscle mass, molecular clocks, and metabolism.
Vanmunster M, Rojo Garcia AV, Pacolet A, Dalle S, Koppo K, Jonkers I, Lories R, Suhr F., Free PMC Article | 06/18/2022 |
| Substratum stiffness signals through integrin-linked kinase and beta1-integrin to regulate midbody proteins and abscission during EMT. | Substratum stiffness signals through integrin-linked kinase and β1-integrin to regulate midbody proteins and abscission during EMT.
Rabie EM, Zhang SX, Dunn CE, Nelson CM., Free PMC Article | 01/22/2022 |
| Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice. | Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice.
Bulus N, Brown KL, Mernaugh G, Böttcher A, Dong X, Sanders CR, Pozzi A, Fässler R, Zent R., Free PMC Article | 08/28/2021 |
| Integrin-linked kinase tunes cell-cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFbeta1. | Integrin-linked kinase tunes cell-cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFβ1.
Kilinc AN, Han S, Barrett LA, Anandasivam N, Nelson CM., Free PMC Article | 08/21/2021 |
| Integrin-linked kinase regulates melanosome trafficking and melanin transfer in melanocytes. | Integrin-linked kinase regulates melanosome trafficking and melanin transfer in melanocytes.
Crawford M, Liu N, Mahdipour E, Barr K, Heit B, Dagnino L., Free PMC Article | 06/5/2021 |
| Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin. | Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin.
Crawford M, Leclerc V, Barr K, Dagnino L. | 09/19/2020 |
| L1CAM-ILK-YAP Mechanotransduction Drives Proliferative Activity of Epithelial Cells in Middle Ear Cholesteatoma. | L1CAM-ILK-YAP Mechanotransduction Drives Proliferative Activity of Epithelial Cells in Middle Ear Cholesteatoma.
Yamamoto-Fukuda T, Akiyama N, Kojima H. | 08/22/2020 |
| ILK was highly expressed in unilateral ureteral obstruction (UUO) model in CD1 mice. Renal fibrosis was aggravated after injection of ILK overexpression plasmid in UUO mice. Western blot results showed that expressions of p-smad3 and smad3 were upregulated during renal fibrosis. ILK participates in the development of renal fibrosis by altering phenotypes of renal tubular epithelial cells via a TGF-beta1/smad pathway. | ILK participates in renal interstitial fibrosis by altering the phenotype of renal tubular epithelial cells via TGF-β1/smad pathway.
Li M, Zhou H, Di J, Yang M, Jia F. | 06/20/2020 |
| critical involvement of ILK in necroptosis through modulation of the RIPK3 and MLKL pathway and highlights the contribution of Collecting Duct Principal Cell injury to the development of inflammation and interstitial fibrosis of the kidney. | Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis.
Huang M, Zhu S, Huang H, He J, Tsuji K, Jin WW, Xie D, Ham O, Capen DE, Lu W, Păunescu TG, Yang B, Lu HAJ., Free PMC Article | 06/6/2020 |
| ILK, a mediator of cell-matrix interactions, is indispensable for retinal angiogenesis. Inactivation of the murine Ilk gene in postnatal endothelial cells results in sprouting defects, reduced endothelial proliferation and disruption of the blood-retina barrier, resembling phenotypes seen in established mouse models of Familial exudative vitreoretinopathy. | Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy.
Park H, Yamamoto H, Mohn L, Ambühl L, Kanai K, Schmidt I, Kim KP, Fraccaroli A, Feil S, Junge HJ, Montanez E, Berger W, Adams RH., Free PMC Article | 03/7/2020 |
| ILK expression may be taken as a predictive determinant of metabolic disorders establishment, because its downregulation seems to correlate with the early imbalance of glucose and glycerol transport and the subsequent loss of systemic homeostasis of these metabolites. | Integrin Linked Kinase (ILK) Downregulation as an Early Event During the Development of Metabolic Alterations in a Short-Term High Fat Diet Mice Model.
Hatem-Vaquero M, Griera M, Garcia-Ayuso D, Campillo S, Bohorquez L, Calleros L, Rodriguez-Puyol D, Rodriguez-Puyol M, de Frutos S. | 02/8/2020 |
| Chronic kidney disease induced by an adenine rich diet upregulates ILK and its depletion prevents the disease progression. | Chronic kidney disease induced by an adenine rich diet upregulates integrin linked kinase (ILK) and its depletion prevents the disease progression.
de Frutos S, Luengo A, García-Jérez A, Hatem-Vaquero M, Griera M, O'Valle F, Rodríguez-Puyol M, Rodríguez-Puyol D, Calleros L. | 02/8/2020 |
| ILK is required for maintaining hepatic transcriptional and metabolic programs that sustain oxidative metabolism, which are required for hepatic maintenance of glucose homeostasis. | Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner.
Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH., Free PMC Article | 01/4/2020 |
| ILK has a critical role in renal-stromal and vascular development, as well as a noncell autonomous role of in ureteric bud branching morphogenesis. | Expression of ILK in renal stroma is essential for multiple aspects of renal development.
Gong X, Guo X, Huang R, Liao H, Zhang Q, Yan J, Luo L, Zhang Q, Qiu A, Sun Y, Liang X. | 07/13/2019 |
| Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. | Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.
Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R., Free PMC Article | 04/22/2019 |
| Lipoxin A4 and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis. | Lipoxin A(4) and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis.
Xu F, Zhou X, Hao J, Dai H, Zhang J, He Y, Hao H. | 02/2/2019 |
| Depletion of integrin-linked kinase (ILK) in the pancreatic epithelial cells results in glucose intolerance due to a loss of the intra-islet vasculature. In turn, blood vessels accumulate at the islet periphery. | The biomechanical properties of an epithelial tissue determine the location of its vasculature.
Kragl M, Schubert R, Karsjens H, Otter S, Bartosinska B, Jeruschke K, Weiss J, Chen C, Alsteens D, Kuss O, Speier S, Eberhard D, Müller DJ, Lammert E., Free PMC Article | 09/8/2018 |
| these data demonstrate the importance of integrin-mediated cell-matrix interactions and ILK signaling in osteoprogenitors in the control of osteoblast functioning during juvenile bone mass acquisition and adult bone remodeling and homeostasis. | Integrin-Linked Kinase Regulates Bone Formation by Controlling Cytoskeletal Organization and Modulating BMP and Wnt Signaling in Osteoprogenitors.
Dejaeger M, Böhm AM, Dirckx N, Devriese J, Nefyodova E, Cardoen R, St-Arnaud R, Tournoy J, Luyten FP, Maes C. | 06/16/2018 |
| We conclude that ILK is critical for maintaining the collecting duct epithelium and renal function and is a key intermediate for periostin activation of signaling pathways involved in cyst growth and fibrosis in PKD. | Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease.
Raman A, Reif GA, Dai Y, Khanna A, Li X, Astleford L, Parnell SC, Calvet JP, Wallace DP., Free PMC Article | 10/7/2017 |
| Ilk and ELMO2 modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin-based adherens junctions. | Integrin-linked kinase and ELMO2 modulate recycling endosomes in keratinocytes.
Ho E, Ivanova IA, Dagnino L. | 10/7/2017 |
| Ilk regulates cellular mechanics facilitating the motility in 3D extracellular matrices. | Integrin-linked kinase regulates cellular mechanics facilitating the motility in 3D extracellular matrices.
Kunschmann T, Puder S, Fischer T, Perez J, Wilharm N, Mierke CT. | 10/7/2017 |
| It was concluded that ILK depletion modifies the transcription of GLUT4, which results in reduced peripheral insulin sensitivity and glucose uptake, suggesting ILK as a molecular target and a prognostic biomarker of insulin resistance. | Peripheral insulin resistance in ILK-depleted mice by reduction of GLUT4 expression.
Hatem-Vaquero M, Griera M, García-Jerez A, Luengo A, Álvarez J, Rubio JA, Calleros L, Rodríguez-Puyol D, Rodríguez-Puyol M, De Frutos S. | 09/16/2017 |