| Gp130-HIF1alpha axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling. | Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.
Kang S, Onishi S, Ling Z, Inoue H, Zhang Y, Chang H, Zhao H, Wang T, Okuzaki D, Matsuura H, Takamatsu H, Oda J, Kishimoto T., Free PMC Article | 01/4/2024 |
| Diabetic Muller-Glial-Cell-Specific Il6ra Knockout Mice Exhibit Accelerated Retinal Functional Decline and Thinning of the Inner Nuclear Layer. | Diabetic Müller-Glial-Cell-Specific Il6ra Knockout Mice Exhibit Accelerated Retinal Functional Decline and Thinning of the Inner Nuclear Layer.
Glass J, Robinson RL, Greenway G, Jones G, Sharma S., Free PMC Article | 12/5/2023 |
| Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise. | Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise.
Minafra AR, Chadt A, Rafii P, Al-Hasani H, Behnke K, Scheller J., Free PMC Article | 11/26/2022 |
| Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion. | Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion.
McNeilly AD, Yianakas A, Gallagher JG, Tarlton J, Ashford ML, McCrimmon RJ., Free PMC Article | 06/18/2022 |
| IL-6R/Signal Transducer and Activator of Transcription 3 Signaling in Keratinocytes rather than in T Cells Induces Psoriasis-Like Dermatitis in Mice. | IL-6R/Signal Transducer and Activator of Transcription 3 Signaling in Keratinocytes rather than in T Cells Induces Psoriasis-Like Dermatitis in Mice.
Ravipati A, Nolan S, Alphonse M, Dikeman D, Youn C, Wang Y, Orlando N, Patrick G, Lee S, Ortines RV, Liu H, Miller RJ, Dillen CA, Marchitto M, Cai SS, Miller LS, Archer NK., Free PMC Article | 05/14/2022 |
| CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity. | CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity.
Duan H, Jing L, Xiang J, Ju C, Wu Z, Liu J, Ma X, Chen X, Liu Z, Feng J, Yan X., Free PMC Article | 05/14/2022 |
| MiR-125-5p/IL-6R axis regulates macrophage inflammatory response and intestinal epithelial cell apoptosis in ulcerative colitis through JAK1/STAT3 and NF-kappaB pathway. | MiR-125-5p/IL-6R axis regulates macrophage inflammatory response and intestinal epithelial cell apoptosis in ulcerative colitis through JAK1/STAT3 and NF-κB pathway.
Yao D, Zhou Z, Wang P, Zheng L, Huang Y, Duan Y, Liu B, Li Y., Free PMC Article | 04/16/2022 |
| Interleukin-6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model. | Interleukin-6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model.
Liu C, Xiong F, Wang L, Chen K, Wu P, Hua L, Zhang Z., Free PMC Article | 12/18/2021 |
| Preclinical development of CD126 CAR-T cells with broad antitumor activity. | Preclinical development of CD126 CAR-T cells with broad antitumor activity.
Mishra AK, Kemler I, Dingli D., Free PMC Article | 08/7/2021 |
| Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation. | Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation.
Zhou M, Aziz M, Denning NL, Yen HT, Ma G, Wang P., Free PMC Article | 06/26/2021 |
| MicroRNA-30b participates in the pathological process of hyperuricemia by regulating interleukin-6 receptor. | MicroRNA-30b participates in the pathological process of hyperuricemia by regulating interleukin-6 receptor.
Zhong X, Chen Y, Yao C, Xu L, Peng Y, Yang Q, Zhao M, Guo X. | 01/16/2021 |
| IL6Ralpha function in myeloid cells modulates the inflammatory response during irritant contact dermatitis. | IL6Rα function in myeloid cells modulates the inflammatory response during irritant contact dermatitis.
Frempah B, Luckett-Chastain LR, Gallucci RM. | 10/10/2020 |
| Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner. | Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner.
Willis EF, MacDonald KPA, Nguyen QH, Garrido AL, Gillespie ER, Harley SBR, Bartlett PF, Schroder WA, Yates AG, Anthony DC, Rose-John S, Ruitenberg MJ, Vukovic J. | 08/22/2020 |
| T cell-intrinsic IL-6Ra classic signaling induces the generation of Th17 cells but at the same time highly immunosuppressive RORgammat(+) biTregs | A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt(+)Foxp3(+) Tregs with Enhanced Suppressive Capacity.
Hagenstein J, Melderis S, Nosko A, Warkotsch MT, Richter JV, Ramcke T, Herrnstadt GR, Scheller J, Yan I, Mittrücker HW, Kluger MA, Steinmetz OM., Free PMC Article | 05/2/2020 |
| Il6ra deletion in smooth muscle cells resulted in increased severity of both Schistosoma- and hypoxia-induced Pulmonary Hypertension. | IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension.
Mickael C, Kumar R, Hernandez-Saavedra D, Kassa B, Sanders L, Koyanagi D, Gu S, Lee MH, Tuder RM, Graham BB., Free PMC Article | 02/22/2020 |
| In summary, the receptor shuffling approach highlights an interchangeable, modular domain structure among IL-6- and IL-12-type cytokine receptors and enabled synthetic IL-35 and IL-39 signaling. | IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling.
Floss DM, Schönberg M, Franke M, Horstmeier FC, Engelowski E, Schneider A, Rosenfeldt EM, Scheller J., Free PMC Article | 07/13/2019 |
| Data (including data from studies using transgenic/knockout mice) suggest that signaling via IL6/IL6R couples autophagy to antioxidant response in insulin-secreting cells. (IL6 = interleukin-6; IL6R = interleukin-6 receptor) | Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response.
Marasco MR, Conteh AM, Reissaus CA, Cupit JE 5th, Appleman EM, Mirmira RG, Linnemann AK., Free PMC Article | 07/28/2018 |
| In the CNS, LPS administration had the greatest effect on IL-6R mRNA. | Multiple lipopolysaccharide (LPS) injections alter interleukin 6 (IL-6), IL-7, IL-10 and IL-6 and IL-7 receptor mRNA in CNS and spleen.
Szot P, Franklin A, Figlewicz DP, Beuca TP, Bullock K, Hansen K, Banks WA, Raskind MA, Peskind ER. | 03/31/2018 |
| IL-6 Receptor is overexpressed in glioma, and it can be used for targeted delivery of the therapeutic ING4 to the tumor. | Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma.
Wang S, Reinhard S, Li C, Qian M, Jiang H, Du Y, Lächelt U, Lu W, Wagner E, Huang R., Free PMC Article | 03/31/2018 |
| role for IL-6R expression in regulating RBC alloimmunization | Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization.
Arneja A, Salazar JE, Jiang W, Hendrickson JE, Zimring JC, Luckey CJ., Free PMC Article | 02/17/2018 |
| There are functional interleukin-6 receptor-alpha on tanycytes at the bottom of the third ventricle, in agreement with the possibility that ventricular administration of IL-6 decreases obesity in mice via an effect on this cell type. | Functional interleukin-6 receptor-α is located in tanycytes at the base of the third ventricle.
Anesten F, Santos C, Gidestrand E, Schéle E, Pálsdóttir V, Swedung-Wettervik T, Meister B, Patrycja Skibicka K, Jansson JO., Free PMC Article | 02/10/2018 |
| we present evidence for the role of M2 phenotype TAM in IL-6 receptor-mediated signals, particularly tyrosine phosphorylation of STAT3, responsible for the prosurvival adaptation of tumor cells to hypoxia. | Tumor associated macrophages provide the survival resistance of tumor cells to hypoxic microenvironmental condition through IL-6 receptor-mediated signals.
Jeong SK, Kim JS, Lee CG, Park YS, Kim SD, Yoon SO, Han DH, Lee KY, Jeong MH, Jo WS. | 12/9/2017 |
| Blockade of the IL-6R receptor by the monoclonal MR16-1 antibody for four weeks started directly after I/R injury did not prevent the process of cardiac remodeling in mice, but rather associated with a deterioration in the process of adverse cardiac remodeling. | Inhibition of Interleukin-6 Receptor in a Murine Model of Myocardial Ischemia-Reperfusion.
Hartman MH, Vreeswijk-Baudoin I, Groot HE, van de Kolk KW, de Boer RA, Mateo Leach I, Vliegenthart R, Sillje HH, van der Harst P., Free PMC Article | 07/29/2017 |
| TNF/IL-6 generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1, DNAX-activation protein 12, and cell proliferation | RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis.
O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF., Free PMC Article | 07/15/2017 |
| C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. | Lipoic Acid Exerts Antioxidant and Anti-inflammatory Effects in Response to Heat Shock in C2C12 Myotubes.
Lee CT, Chang LC, Wu PF. | 03/11/2017 |