| Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB. | Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB.
Lou W, Yan J, Wang W., Free PMC Article | 05/29/2021 |
| Chronic shift-lag promotes NK cell ageing and impairs immunosurveillance in mice by decreasing the expression of CD122. | Chronic shift-lag promotes NK cell ageing and impairs immunosurveillance in mice by decreasing the expression of CD122.
Zeng X, Liang C, Yao J., Free PMC Article | 05/15/2021 |
| The Abundance and Availability of Cytokine Receptor IL-2Rbeta (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells. | The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells.
Keller HR, Kim HK, Jo Y, Gress RE, Hong C, Park JH., Free PMC Article | 02/13/2021 |
| Combined costimulatory and CD122 blockade improved survival of transplanted tissue in mice and nonhuman primates by controlling proliferation and effector function of CD8+ T cells. | CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection.
Mathews DV, Dong Y, Higginbotham LB, Kim SC, Breeden CP, Stobert EA, Jenkins J, Tso JY, Larsen CP, Adams AB., Free PMC Article | 09/14/2019 |
| Diabetes was accelerated in male and female NOD mice in which IL-2Rbeta signaling was modestly and selectively reduced in T cells. | Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.
Dwyer CJ, Bayer AL, Fotino C, Yu L, Cabello-Kindelan C, Ward NC, Toomer KH, Chen Z, Malek TR., Free PMC Article | 08/4/2018 |
| The larger pool of IL-2Rbeta chains in CD8+ T cells is required to sustain IL-2 signaling and contributes to the quantitatively greater proliferative response to IL-2 relative to that of CD4+ mouse primary T cell cultures. | IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4(+) and CD8(+) T cells.
Smith GA, Taunton J, Weiss A., Free PMC Article | 08/4/2018 |
| Genetic ablation of the IL2Rbeta chain on CD8(+) T cells restrains inhibitory receptor induction, in particular 2B4 and Tim-3; precludes terminal differentiation of highly defective PD-1(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7-dependent signals. Together, we ascribe a previously unexpected role to IL-2 and IL-15 as instigators of CD8(+) T-cell exhaustion during chronic viral infe... | IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection.
Beltra JC, Bourbonnais S, Bédard N, Charpentier T, Boulangé M, Michaud E, Boufaied I, Bruneau J, Shoukry NH, Lamarre A, Decaluwe H., Free PMC Article | 01/27/2018 |
| c-REL, but not IkappaBNS, controlled the generation of classical CD25(+)Foxp3(-) precursors via direct binding to the Cd25 locus; propose that CD4(+)GITR(+)CD122(+)CD25(-)Foxp3(-) cells represent a Treg pre-precursor population, whose transition into Treg precursors is mediated via c-REL | c-REL and IκB(NS) Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors.
Schuster M, Plaza-Sirvent C, Matthies AM, Heise U, Jeron A, Bruder D, Visekruna A, Huehn J, Schmitz I. | 10/14/2017 |
| Results indicate that conjugated-interleukin-2 (IL2) protein derived from NKTR-214 occupy interleukin-2 (IL2) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 protein. | Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.
Charych D, Khalili S, Dixit V, Kirk P, Chang T, Langowski J, Rubas W, Doberstein SK, Eldon M, Hoch U, Zalevsky J., Free PMC Article | 10/7/2017 |
| Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2-beta receptor response, to date classically described only in immune cells. | Glomerular common gamma chain confers B- and T-cell-independent protection against glomerulonephritis.
Luque Y, Cathelin D, Vandermeersch S, Xu X, Sohier J, Placier S, Xu-Dubois YC, Louis K, Hertig A, Bories JC, Vasseur F, Campagne F, Di Santo JP, Vosshenrich C, Rondeau E, Mesnard L. | 09/30/2017 |
| CBP physically associates with the IL-2 receptor beta-chain. CBP, found in the nucleus in resting CTLL-2 cells, relocates to the cytoplasm after IL-2 stimulation in an MEK/ERK pathway-dependent manner. Thus, IL-2-mediated acetylation plays an important role in the modulation of cytokine signaling and T cell fate. | Acetylation Modulates IL-2 Receptor Signaling in T Cells.
Kuwabara T, Kasai H, Kondo M. | 07/29/2017 |
| Intratesticular inoculation with donor antigens promotes long-term skin allograft survival induced by conventional costimulatory blockade via the induction of both CD8 + CD122+ and CD4 + CD25+ Treg cells. | Donor-antigen Inoculation in the Testis Promotes Skin Allograft Acceptance Induced by Conventional Costimulatory Blockade via Induction of CD8 + CD122+ and CD4 + CD25+ Regulatory T Cells.
Cong L, Wang SF, Zhao ZL, Yang RY. | 08/13/2016 |
| IL-2Rbeta-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa. | IL-2Rβ-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa.
Yuan X, Dee MJ, Altman NH, Malek TR., Free PMC Article | 04/18/2015 |
| Thymic development of CD4+Foxp3+ regulatory T cells (Tregs) is highly dysregulated in IL-2 receptor (2Rbeta)-deficient mice. | IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development.
Cheng G, Yu A, Dee MJ, Malek TR., Free PMC Article | 03/30/2013 |
| CDCD11c+B220+CD122+ cells play an important role in xenograft rejection. Their absence in NOG mice may be critical in supporting the successful engraftment of xenotransplants. | Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rγnull mice is attributed to a lack of CD11c+B220+CD122+ cells.
Ito R, Katano I, Ida-Tanaka M, Kamisako T, Kawai K, Suemizu H, Aiso S, Ito M. | 01/12/2013 |
| This study demonstrated that IL-12 signaling plays a complex role during the induction of tolerance as the presence of exogenous IL-12 and the lack of IL-12 signaling both prevent complete induction of tolerance. | Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and experimental autoimmune encephalomyelitis severity in the absence of IL-12 receptor signaling.
Fitzgerald DC, Zhang GX, Yu S, Cullimore ML, Zhao Z, Rostami A., Free PMC Article | 07/14/2012 |
| Continuous activation of the CD122/STAT-5 signaling pathway characterize regulatory lineage differentiation in the murine thymus. | Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus.
Goldstein JD, Balderas RS, Marodon G., Free PMC Article | 08/27/2011 |
| Results indicate that potential nuclear function of cleaved interleukin-2 receptor beta-chain and IL-15 receptor alpha-chain subunits is not plausible. | Lack of nuclear translocation of cytoplasmic domains of IL-2/IL-15 receptor subunits.
Fujii H, Hoshino A., Free PMC Article | 01/21/2010 |
| IL2R beta-chain induces growth potential for glandular epithelial cells and an immune-privileged condition mediated by CD25+regulatory-T cells. | Spontaneous endometrial hyperplasia in the uteri of IL-2 receptor beta-chain transgenic mice.
Kusakabe K, Kiso Y, Hondo E, Takeshita A, Kato K, Okada T, Shibata MA, Otsuki Y. | 01/21/2010 |
| A population of memory CD8 T cells generated under sterile inflammatory conditions is identified by intermediate expression levels of CD122/CD44 and is involved in recall contact hypersensitivity reactions responsible for allergic contact dermatitis. | Characterization of a CD44/CD122int memory CD8 T cell subset generated under sterile inflammatory conditions.
Mbitikon-Kobo FM, Vocanson M, Michallet MC, Tomkowiak M, Cottalorda A, Angelov GS, Coupet CA, Djebali S, Marçais A, Dubois B, Bonnefoy-Bérard N, Nicolas JF, Arpin C, Marvel J. | 01/21/2010 |
| IL-9Ralpha and IL-2Rbeta homodimers efficiently mediate constitutive activation of ALL-associated JAK1 mutants. | Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.
Hornakova T, Staerk J, Royer Y, Flex E, Tartaglia M, Constantinescu SN, Knoops L, Renauld JC., Free PMC Article | 01/21/2010 |
| subset of IL-2-dependent targets is indexed to a low IL-2R signaling threshold | A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.
Yu A, Zhu L, Altman NH, Malek TR., Free PMC Article | 01/21/2010 |
| Common gamma-chain binding-dependent activation of the shared IL-15/IL-2 receptor beta/common gamma signaling pathway may play an important role in the activation of natural killer (NK) cells and CD8-positive T cells, resulting in tumor growth inhibition. | Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.
Rowley J, Monie A, Hung CF, Wu TC., Free PMC Article | 01/21/2010 |
| local blockade of the beta-chain of the IL-2R restored an immunosuppressive cytokine milieu in the lung that ameliorated both inflammation and airway hyperresponsiveness in experimental allergic asthma | IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo.
Doganci A, Karwot R, Maxeiner JH, Scholtes P, Schmitt E, Neurath MF, Lehr HA, Ho IC, Finotto S. | 01/21/2010 |
| a signal mediated by IL-2Rbeta is essential for the development and homeostasis of Foxp3(+) Treg in vivo | IL-2Rbeta links IL-2R signaling with Foxp3 expression.
Soper DM, Kasprowicz DJ, Ziegler SF. | 01/21/2010 |