| IL-12p40 deletion reduces M1 macrophage polarization and alleviates cardiac remodeling via regulating Th17 cells differentiation, but not gammadeltaT 17 cells, in TAC mice. | IL-12p40 deletion reduces M1 macrophage polarization and alleviates cardiac remodeling via regulating Th17 cells differentiation, but not γδT 17 cells, in TAC mice.
Pan H, Ji Q, Zhao M, Zheng Z, Lu X, Feng Y, Gan L, Ye J, Wan J, Ye D. | 05/30/2024 |
| Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells. | Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells.
Rixon JA, Fong KD, Morris C, Nguyen AT, Depew CE, McSorley SJ., Free PMC Article | 02/5/2024 |
| IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice. | IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice.
Mittereder LR, Swoboda J, De Pascalis R, Elkins KL., Free PMC Article | 04/4/2023 |
| IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury. | IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.
Rosas Almanza J, Stehlik KE, Page JJ, Xiong SH, Tabor EG, Aperi B, Patel K, Kodali R, Kurpad S, Budde MD, Tarima S, Swartz K, Kroner A. | 10/29/2022 |
| Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model. | Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model.
Nuñez R, Rodriguez MJ, Palomares F, Gomez F, Jabato FM, Cordoba-Caballero J, Seoane P, Losada J, Rojo J, Torres MJ, Perkins JR, Mayorga C., Free PMC Article | 03/12/2022 |
| The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo. | The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Gerber AN, Abdi K, Singh NJ., Free PMC Article | 02/19/2022 |
| Role of p40(phox) in host defense against Citrobacter rodentium infection. | Role of p40(phox) in host defense against Citrobacter rodentium infection.
Yan Y, Li Y, Lv M, Li W, Shi HN., Free PMC Article | 01/8/2022 |
| Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rbeta1 and subsequent signal transduction. | Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction.
Georgy J, Arlt Y, Moll JM, Ouzin M, Weitz HT, Gremer L, Willbold D, Grötzinger J, Thives-Kurenbach F, Scheller J, Floss DM., Free PMC Article | 12/18/2021 |
| Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers. | Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers.
Ahn HH, Carrington C, Hu Y, Liu HW, Ng C, Nam H, Park A, Stace C, West W, Mao HQ, Pomper MG, Ullman CG, Minn I., Free PMC Article | 11/6/2021 |
| Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice. | Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice.
Eede P, Obst J, Benke E, Yvon-Durocher G, Richard BC, Gimber N, Schmoranzer J, Böddrich A, Wanker EE, Prokop S, Heppner FL., Free PMC Article | 05/8/2021 |
| Ghrelin effects on mitochondrial fitness modulates macrophage function. | Ghrelin effects on mitochondrial fitness modulates macrophage function.
Corrêa da Silva F, Aguiar C, Pereira JAS, de Brito Monteiro L, Davanzo GG, Codo AC, Pimentel de Freitas L, Berti AS, Lopes Ferrucci D, Castelucci BG, Consonni SR, Carvalho HF, Moraes-Vieira PMM. | 09/5/2020 |
| Interleukin-12p40 variant form reduces Interleukin-12p80 secretion. | Interleukin-12p40 variant form reduces Interleukin-12p80 secretion.
Oshikiri Y, Nara H, Takeda Y, Araki A, Nemoto N, Gazi MY, Saito S, Saitoh S, Nakajima O, Asao H. | 08/22/2020 |
| Data suggest that 17beta-estradiol induced an immunological response in female bone marrow-derived macrophages resulting in Leishmania mexicana parasite destruction and high production of IL-12p70 and NO synthesis. | Cytokine regulation of female-macrophage resistance to Leishmania mexicana parasites. Role of IL-12p70.
Isaac-Márquez AP, Lezama-Dávila CM. | 05/16/2020 |
| Donor memory CD8+ T cell activation within allografts subjected to prolonged cold ischemic storage requires memory CD4+ T cell stimulation of graft dendritic cells to produce p40 homodimers, but not IL-12 p40/p35 heterodimers. Targeting p40 abrogates memory CD8+ T cell proliferation within the allografts and their ability to mediate CTLA-4Ig-resistant allograft rejection. | Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells.
Tsuda H, Su CA, Tanaka T, Ayasoufi K, Min B, Valujskikh A, Fairchild RL., Free PMC Article | 12/7/2019 |
| IL12p40 depletion promotes the development of abdominal aortic aneurysm, in part, by facilitating recruitment of M2-like macrophages and potentiating aortic stiffness and fibrosis mediated by Tgfbeta2. | Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.
Sharma N, Dev R, Belenchia AM, Aroor AR, Whaley-Connell A, Pulakat L, Hans CP., Free PMC Article | 12/7/2019 |
| this study shows that lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis | Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis.
Schönfelder T, Brandt M, Kossmann S, Knopp T, Münzel T, Walter U, Karbach SH, Wenzel P., Free PMC Article | 11/30/2019 |
| these findings identify CNBP as important regulator of c-Rel-dependent IL-12beta gene transcription and Th1 immunity. | CNBP controls IL-12 gene transcription and Th1 immunity.
Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA., Free PMC Article | 09/7/2019 |
| This report shows that in the absence of both STAT6 and IL-12p40 signaling, Leishmania major-infected BALB/c mice remain susceptible to infection but demonstrate higher tolerance to pathogenic threat as they display smaller footpad lesions compared to IL-12p40-/- mice. | STAT6 Mediates Footpad Immunopathology in the Absence of IL-12p40 Following Infection of Susceptible BALB/c Mice With Leishmania major.
Kauffmann F, Meert E, de Jonge K, Elkrim Y, Hanot Mambres D, Denis O, Muraille E, Magez S, De Trez C., Free PMC Article | 05/11/2019 |
| In macrophages, SCIMP is constitutively associated with the Lyn tyrosine kinase, is required for tyrosine phosphorylation of TLR4, and facilitates TLR-inducible production of the IL-6 and IL-12p40. | SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.
Luo L, Bokil NJ, Wall AA, Kapetanovic R, Lansdaal NM, Marceline F, Burgess BJ, Tong SJ, Guo Z, Alexandrov K, Ross IL, Hibbs ML, Stow JL, Sweet MJ., Free PMC Article | 11/24/2018 |
| IL-12 receptor signalling in keratinocytes initiates a protective transcriptional programme that limits skin inflammation. | IL-12 protects from psoriasiform skin inflammation.
Kulig P, Musiol S, Freiberger SN, Schreiner B, Gyülveszi G, Russo G, Pantelyushin S, Kishihara K, Alessandrini F, Kündig T, Sallusto F, Hofbauer GF, Haak S, Becher B., Free PMC Article | 09/1/2018 |
| Results show the overproduction of IL-12/23p40 in dendritic cells, leading to Th1 and Th17 programs in a mouse model of Yersinia enterocolitica-induced reactive arthritis. | IL-12/23p40 overproduction by dendritic cells leads to an increased Th1 and Th17 polarization in a model of Yersinia enterocolitica-induced reactive arthritis in TNFRp55-/- mice.
Mayordomo AC, Silva JE, Gorlino CV, Arias JL, Berón W, Di Genaro MS., Free PMC Article | 07/7/2018 |
| this study demonstrates that regulation of IL-12p40 by hypoxia-inducible factor-1alpha controls Th1/Th17 responses to prevent mucosal inflammation | Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation.
Marks E, Naudin C, Nolan G, Goggins BJ, Burns G, Mateer SW, Latimore JK, Minahan K, Plank M, Foster PS, Callister R, Veysey M, Walker MM, Talley NJ, Radford-Smith G, Keely S. | 06/23/2018 |
| the nuclear localized CA-VI B selectively promotes IL-12 expression by interaction with protein arginine N-methyltransferase 5 (PRMT5), which reduces symmetric dimethylation of histone H3 arginine 8 modification (H3R8me2s) at Il12 promoters to facilitate chromatin accessibility, selectively enhancing c-Rel binding to the Il12b promoter. | Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response.
Xu J, Xu X, Wang B, Ma Y, Zhang L, Xu H, Hu Y, Wu J, Cao X., Free PMC Article | 05/26/2018 |
| The authors found that the expressions of the mRNAs of both IL-12p35 and IL-12p40 were significantly reduced in the oxygen-induced retinopathy retinas compared to that of the room air-raised control. The results suggest that IL-12 plays important roles in inhibiting pathological retinal neovascularization. | Interleukin-12 inhibits pathological neovascularization in mouse model of oxygen-induced retinopathy.
Zhou Y, Yoshida S, Kubo Y, Kobayashi Y, Nakama T, Yamaguchi M, Ishikawa K, Nakao S, Ikeda Y, Ishibashi T, Sonoda KH., Free PMC Article | 05/19/2018 |
| High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro.( | High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro.
de Santana FR, Dalboni LC, Nascimento KF, Konno FT, Alvares-Saraiva AM, Correia MSF, Bomfim MDC, Casarin RCV, Perez EC, Lallo MA, Peres GB, Laurenti MD, Benites NR, Buchi DF, Bonamin LV. | 01/6/2018 |