| CYP7A1 Gene Induction via SHP-Dependent or Independent Mechanisms can Increase the Risk of Drug-Induced Liver Injury Independently or in Synergy with BSEP Inhibition. | CYP7A1 Gene Induction via SHP-Dependent or Independent Mechanisms can Increase the Risk of Drug-Induced Liver Injury Independently or in Synergy with BSEP Inhibition.
Niu C, Xie X, Liu R, Liang X, Hu Y, Lai Y. | 05/7/2024 |
| Pharmacological modulation of cholesterol 7alpha-hydroxylase (CYP7A1) as a therapeutic strategy for hypercholesterolemia. | Pharmacological modulation of cholesterol 7α-hydroxylase (CYP7A1) as a therapeutic strategy for hypercholesterolemia.
Yu Cai Lim M, Kiat Ho H. | 02/2/2024 |
| [Cholesterol 7alpha-Hydroxylase Gene-204A/C Polymorphism in Normal and Gestational Diabetic Pregnancies]. | [Cholesterol 7α-Hydroxylase Gene-204A/C Polymorphism in Normal and Gestational Diabetic Pregnancies].
Liu SX, Bai H, Guan LB, Liu XH, Fan P, Zhou M, Wu YJ, Tang FM, Wang YF, Li DH., Free PMC Article | 04/1/2023 |
| Common Genetic Variants in the Bile Acid Synthesis Enzyme CYP7A1 Are Associated With Severe Primary Bile Acid Diarrhea. | Common Genetic Variants in the Bile Acid Synthesis Enzyme CYP7A1 Are Associated With Severe Primary Bile Acid Diarrhea.
Balesaria S, Pattni SS, Johnston IM, Nolan JD, Appleby RN, Walters JRF. | 09/3/2022 |
| The association of cytochrome 7A1 and ATP-binding cassette G8 genotypes with type 2 diabetes among Jordanian patients. | The association of cytochrome 7A1 and ATP-binding cassette G8 genotypes with type 2 diabetes among Jordanian patients.
Abed E, Jarrar Y, Alhawari H, Abdullah S, Zihlif M. | 07/2/2022 |
| Association of cholesterol 7alpha-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population. | Association of cholesterol 7α-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population.
Sezer E, Can Demirdöğen B, Demirkaya Ş, Bulut G, Akkulak M, Evin E, Adalı O. | 04/9/2022 |
| Developmental regulation of the gut-liver (FGF19-CYP7A1) axis in neonates. | Developmental regulation of the gut-liver (FGF19-CYP7A1) axis in neonates.
Memon N, Griffin IJ, Lee CW, Herdt A, Weinberger BI, Hegyi T, Carayannopoulos MO, Aleksunes LM, Guo GL., Free PMC Article | 11/21/2020 |
| relationship between CYP7A1 polymorphisms, coronary artery disease & serum lipid markers | The relationship between CYP7A1 polymorphisms, coronary artery disease & serum lipid markers.
Iwanicki T, Balcerzyk A, Niemiec P, Trautsolt W, Grzeszczak W, Ochalska-Tyka A, Krauze J, Nowak T, Żak I. | 06/13/2020 |
| Genetic variants in CYP7A1 which are associated with increased levels of LDL cholesterol, are associated with an increased risk of both myocardial infarction and gallstone disease. | Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease.
Qayyum F, Lauridsen BK, Frikke-Schmidt R, Kofoed KF, Nordestgaard BG, Tybjærg-Hansen A. | 12/7/2019 |
| Two interacting regulatory SNPs modulate CYP7A1 expression and are associated with risk of coronary artery disease and diabetes mellitus. | Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression.
Wang D, Hartmann K, Seweryn M, Sadee W., Free PMC Article | 09/21/2019 |
| SNPs rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) may work in conjunction with each other to amplify individual genotyping impacts on serum cholesterol responses to dairy consumption. | The combination of single nucleotide polymorphisms rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) is associated with differing serum cholesterol responses to dairy consumption.
Abdullah MMH, Eck PK, Couture P, Lamarche B, Jones PJH. | 02/2/2019 |
| miR-17 is a novel regulator of CYP7A1 signaling in hepatic lipid metabolism, by which miR-17 may mediate hepatosteatosis. | MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1.
Gong R, Lv X, Liu F., Free PMC Article | 11/3/2018 |
| Rev-erbalpha regulates Cyp7a1 and cholesterol metabolism through its repression of the Lrh-1 receptor. | REV-ERBα Regulates CYP7A1 Through Repression of Liver Receptor Homolog-1.
Zhang T, Zhao M, Lu D, Wang S, Yu F, Guo L, Wen S, Wu B. | 10/20/2018 |
| The analysis of the relationship of polymorphic variants CYP7A1 to lipid metabolic disturbances makes it possible to consider the AA homozygous genotype of variant mutation CYP7A1 rs 38088607 as protective against Dyslipidemia. | [CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism].
Zhaldak DA, Melekhovets OK, Orlovskyi VF. | 03/31/2018 |
| Genetic polymorphisms of CYP7A1 may be associated with susceptibility to anti-tuberculosis drug-induced hepatotoxicity in the Chinese population | CYP7A1, BAAT and UGT1A1 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity.
Chen R, Wang J, Tang SW, Zhang Y, Lv XZ, Wu SS, Yang ZR, Xia YY, Chen DF, Zhan SY. | 02/17/2018 |
| The pronounced TC reduction in G allele carriers of rs3808607 observed in the previous study may be due to enhanced bile acid synthesis in response to high-viscosity beta-glucan consumption in those individuals. | Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism.
Wang Y, Harding SV, Thandapilly SJ, Tosh SM, Jones PJH, Ames NP. | 12/16/2017 |
| Current studies suggest that increased Cyp7a1 expression and bile acid synthesis ameliorate hepatic inflammation through activation of FXR | Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Liu H, Pathak P, Boehme S, Chiang JL., Free PMC Article | 08/5/2017 |
| This study provides evidence that individuals carrying the G allele of CYP7A1 single nucleotide polymorphism are more responsive to high molecular weight beta-glucan's effect of lowering circulating cholesterol concentrations than individuals homozygous for the T allele. | High-Molecular-Weight β-Glucan Decreases Serum Cholesterol Differentially Based on the CYP7A1 rs3808607 Polymorphism in Mildly Hypercholesterolemic Adults.
Wang Y, Harding SV, Eck P, Thandapilly SJ, Gamel TH, Abdel-Aal el-SM, Crow GH, Tosh SM, Jones PJ, Ames NP. | 06/24/2017 |
| Genetic variations in ABCG5, CYP7A1, and DHCR7 may contribute to differing responses of serum cholesterol to dairy intake among healthy adults. | Common Variants in Cholesterol Synthesis- and Transport-Related Genes Associate with Circulating Cholesterol Responses to Intakes of Conventional Dairy Products in Healthy Individuals.
Abdullah MM, Cyr A, Lépine MC, Eck PK, Couture P, Lamarche B, Jones PJ. | 06/10/2017 |
| The promoter polymorphism of the CYP7A1 gene has a pronounced impact on diurnal variation in CYP7A1 activity. | Diurnal variation in cholesterol 7α-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene.
Vlachova M, Blahova T, Lanska V, Leníček M, Pitha J, Vítek L, Kovar J., Free PMC Article | 02/25/2017 |
| The finding that overexpression of HIF-1alpha increased the activity of the CYP7A1 promoter suggested that hypoxia decreased the expression of CYP7A1 in a HIF-1-independent manner. | Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism.
Moon Y, Park B, Park H., Free PMC Article | 01/28/2017 |
| Macrophage cholesterol efflux in patients with type II diabetes mellitus was significantly reduced, and that this reduction was associated with the down-regulation of CYP7A1 expression. | Correlation between the decrease of cholesterol efflux from macrophages in patients with type II diabetes mellitus and down-regulated CYP7A1 expression.
Bao LD, Li CQ, Peng R, Ren XH, Ma RL, Wang Y, Lv HJ. | 06/11/2016 |
| CYP7A1 and APOE isoform are associated with the extent of reduction in circulating LDL cholesterol in response to plant sterols consumption. | CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial.
MacKay DS, Eck PK, Gebauer SK, Baer DJ, Jones PJ. | 01/16/2016 |
| The CYP7A1 rs7833904 polymorphism may modify the risk of CAD. | CYP7A1 gene polymorphism located in the 5' upstream region modifies the risk of coronary artery disease.
Iwanicki T, Balcerzyk A, Niemiec P, Nowak T, Ochalska-Tyka A, Krauze J, Kosiorz-Gorczynska S, Grzeszczak W, Zak I., Free PMC Article | 12/26/2015 |
| The CYP7A1 crystallographic models identify residues involved in cholest-4-en-3-one binding. | Structural characterization of human cholesterol 7α-hydroxylase.
Tempel W, Grabovec I, MacKenzie F, Dichenko YV, Usanov SA, Gilep AA, Park HW, Strushkevich N., Free PMC Article | 11/14/2015 |