| Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice. | Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice.
Hu S, Kou Y, Liu X, Rong W, Han H, Zhang G., Free PMC Article | 04/15/2024 |
| Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine. | Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine.
Okumura M, Hamada A, Ohsaka F, Tsuruta T, Hira T, Sonoyama K. | 07/10/2021 |
| Serotonin 5-HT4 receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin. | Serotonin 5-HT(4) receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin.
Schill Y, Bijata M, Kopach O, Cherkas V, Abdel-Galil D, Böhm K, Schwab MH, Matsuda M, Compan V, Basu S, Bijata K, Wlodarczyk J, Bard L, Cole N, Dityatev A, Zeug A, Rusakov DA, Ponimaskin E., Free PMC Article | 06/19/2021 |
| Findings of the present in vitro study enrich the understanding and provide insight roles of 5-HT4R in embryonic brain development by promoting the growth of hippocampal neurons. | Role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice.
Agrawal L, Vimal SK, Shiga T. | 07/25/2020 |
| Synaptic potentiation is mediated by 5-HT4 receptors and that systemic modulation of 5-HT4 receptor function can bidirectionally impact memory formation. | Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation.
Teixeira CM, Rosen ZB, Suri D, Sun Q, Hersh M, Sargin D, Dincheva I, Morgan AA, Spivack S, Krok AC, Hirschfeld-Stoler T, Lambe EK, Siegelbaum SA, Ansorge MS., Free PMC Article | 08/10/2019 |
| Impeding serotonergic signaling preferentially gates spike-timing-dependent long-term depression (t-LTD) at thalamostriatal synapses. This t-LTD requires dampened activity of the 5-HT4 receptor subtype. | Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits.
Cavaccini A, Gritti M, Giorgi A, Locarno A, Heck N, Migliarini S, Bertero A, Mereu M, Margiani G, Trusel M, Catelani T, Marotta R, De Luca MA, Caboche J, Gozzi A, Pasqualetti M, Tonini R. | 08/3/2019 |
| Gut microbiota-produced Tryptamine activates epithelial 5-HT4R serotonin receptor to increase cAMP level and drive colonic fluid secretion. | Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion.
Bhattarai Y, Williams BB, Battaglioli EJ, Whitaker WR, Till L, Grover M, Linden DR, Akiba Y, Kandimalla KK, Zachos NC, Kaunitz JD, Sonnenburg JL, Fischbach MA, Farrugia G, Kashyap PC., Free PMC Article | 07/13/2019 |
| Prefrontal cortex 5-HT4Rs mediate hypophagia following stress. | Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress.
Jean A, Laurent L, Delaunay S, Doly S, Dusticier N, Linden D, Neve R, Maroteaux L, Nieoullon A, Compan V. | 06/16/2018 |
| Knock down serotonin receptors 5-HTR3 and 5-HTR4 in neonatal cardiomyocytes resulted in significant increase of cell damage in response to hypoxia, and also led to alternation in heart beating. | 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrial functions.
Wang Q, Zhang H, Xu H, Guo D, Shi H, Li Y, Zhang W, Gu Y., Free PMC Article | 05/26/2018 |
| Study shows that in the murine gastrointestinal tract, activation of 5-HT4 receptors with prucalopride enhances cholinergic contractions, illustrating facilitation of myenteric cholinergic neurotransmission. | 5-HT(4) receptors facilitate cholinergic neurotransmission throughout the murine gastrointestinal tract.
Pauwelyn V, Lefebvre RA. | 05/5/2018 |
| These data suggest that correlated expression of Slc6a4 and Htr4 likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut. | Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes.
Reigstad CS, Linden DR, Szurszewski JH, Sonnenburg JL, Farrugia G, Kashyap PC., Free PMC Article | 02/17/2018 |
| altered 5-HT4R expression may affect the development of cortical glutamatergic control of the dorsal raphe nucleus. | Serotonin 5-HT(4) receptors modulate the development of glutamatergic input to the dorsal raphe nucleus.
Chen A, Hubbert KD, Foroudi PF, Lu VF, Janušonis S. | 10/28/2017 |
| Results demonstrate that the absence of 5-HT4 receptors triggers adaptive changes that could maintain emotional states, and that the behavioural and molecular effects of fluoxetine under pathological depression appear to be critically dependent on 5-HT4 receptors. | The absence of 5-HT(4) receptors modulates depression- and anxiety-like responses and influences the response of fluoxetine in olfactory bulbectomised mice: Adaptive changes in hippocampal neuroplasticity markers and 5-HT(1A) autoreceptor.
Amigó J, Díaz A, Pilar-Cuéllar F, Vidal R, Martín A, Compan V, Pazos A, Castro E. | 07/15/2017 |
| HTR4's role in pulmonary function likely relates to neural innervation and control of breathing. | Vagal innervation is required for pulmonary function phenotype in Htr4(-/-) mice.
House JS, Nichols CE, Li H, Brandenberger C, Virgincar RS, DeGraff LM, Driehuys B, Zeldin DC, London SJ., Free PMC Article | 06/24/2017 |
| 5-HT4 receptor regulating insulin secretion and acting as a potential drug target in diabetes treatment | Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion.
Chen H, Hong F, Chen Y, Li J, Yao YS, Zhang Y, Zheng LF, Zhu JX. | 03/25/2017 |
| Its activation facilitates neurogenesis of injured enteric neurons.(review) | Activation of 5-HT4 receptors facilitates neurogenesis of injured enteric neurons at an anastomosis in the lower gut.
Takaki M, Goto K, Kawahara I, Nabekura J., Free PMC Article | 05/28/2016 |
| The findings of altered lung function and increased AHR in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies. | Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.
House JS, Li H, DeGraff LM, Flake G, Zeldin DC, London SJ., Free PMC Article | 05/2/2015 |
| Our in vivo data using pharmacologic and genetic approaches suggest that 5-HT(4) receptors are not involved in the bronchial hyperresponsiveness to 5-HT in cigarette smoke-exposed mice | Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice.
Dupont LL, Bracke KR, De Maeyer JH, Compan V, Joos GF, Lefebvre RA, Brusselle GG. | 01/3/2015 |
| 5-HT system in the small intestine may play a critical role in regulating circadian rhythms through 5-HT3/5-HT4-receptor activation. | Involvement of 5-HT₃ and 5-HT₄ receptors in the regulation of circadian clock gene expression in mouse small intestine.
Aoki N, Watanabe H, Okada K, Aoki K, Imanishi T, Yoshida D, Ishikawa R, Shibata S. | 10/18/2014 |
| A highly conserved motif in the ligand-binding pocket of serotonin receptors is an important participant in ligand binding. | A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4).
Padayatti PS, Wang L, Gupta S, Orban T, Sun W, Salom D, Jordan SR, Palczewski K, Chance MR., Free PMC Article | 12/14/2013 |
| These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis. | A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor.
Profirovic J, Strekalova E, Urao N, Krbanjevic A, Andreeva AV, Varadarajan S, Fukai T, Hen R, Ushio-Fukai M, Voyno-Yasenetskaya TA., Free PMC Article | 06/1/2013 |
| Endogenous 5-HT exerts a dual role in the pathogenesis of indomethacin-induced intestinal lesions: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. | Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors.
Kato S, Matsuda N, Matsumoto K, Wada M, Onimaru N, Yasuda M, Amagase K, Horie S, Takeuchi K. | 12/22/2012 |
| This review presented that the 5HT4 RECEPTOR knockout mice show a correlation between 5-HT firing rate and depressive/resilience phenotypes. | Characterization of serotonin neurotransmission in knockout mice: implications for major depression.
Domínguez-López S, Howell R, Gobbi G. | 11/17/2012 |
| These results show that prenatal stress and reduced 5-HT levels can alter 5-HT(4)R expression in the developing forebrain and that some 5-HT(4)R splice variants. | Effects of prenatal stress and monoaminergic perturbations on the expression of serotonin 5-HT₄ and adrenergic β₂ receptors in the embryonic mouse telencephalon.
Chen A, Kelley LD, Janušonis S. | 09/22/2012 |
| This study demonistrated that alternatively spliced multiple transcripts of 5-hydroxytryptamine receptor expression in heart. | Identification of alternatively spliced multiple transcripts of 5-hydroxytryptamine receptor in mouse.
Azim S, Banday AR, Tabish M. | 08/4/2012 |