| Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety. | Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety.
Rohn TT, Radin D, Brandmeyer T, Seidler PG, Linder BJ, Lytle T, Mee JL, Macciardi F., Free PMC Article | 03/22/2024 |
| CX3CR1 mediates motor dysfunction in mice through 5-HTR2a. | CX3CR1 mediates motor dysfunction in mice through 5-HTR2a.
Pei J, Zou Y, Wan C, Liu S, Hu B, Li Z, Tang Z. | 02/4/2024 |
| 5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice. | 5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice.
Jiang Y, Zhou J, Song BL, Wang Y, Zhang DL, Zhang ZT, Li LF, Liu YJ. | 09/25/2023 |
| Glucocorticoid receptor dysregulation underlies 5-HT2AR-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model. | Glucocorticoid receptor dysregulation underlies 5-HT(2A)R-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model.
Saunders JM, Muguruza C, Sierra S, Moreno JL, Callado LF, Meana JJ, Beardsley PM, González-Maeso J., Free PMC Article | 01/28/2023 |
| Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes. | Serotonin Receptor 5-HT(2A) Regulates TrkB Receptor Function in Heteroreceptor Complexes.
Ilchibaeva T, Tsybko A, Zeug A, Müller FE, Guseva D, Bischoff S, Ponimaskin E, Naumenko V., Free PMC Article | 08/20/2022 |
| Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3. | Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3.
Zhao X, Ozols AB, Meyers KT, Campbell J, McBride A, Marballi KK, Maple AM, Raskin C, Mishra A, Noss SM, Beck KL, Khoshaba R, Bhaskara A, Godbole MN, Lish JR, Kang P, Hu C, Palner M, Overgaard A, Knudsen GM, Gallitano AL., Free PMC Article | 05/21/2022 |
| 5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction. | 5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction.
Nakao K, Singh M, Sapkota K, Fitzgerald A, Hablitz JJ, Nakazawa K., Free PMC Article | 05/14/2022 |
| PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization. | PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.
Hayata-Takano A, Shintani Y, Moriguchi K, Encho N, Kitagawa K, Nakazawa T, Hashimoto H., Free PMC Article | 02/19/2022 |
| HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling. | HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling.
Gao W, Guo N, Zhao S, Chen Z, Zhang W, Yan F, Liao H, Chi K., Free PMC Article | 09/25/2021 |
| Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT2A receptor activation. | Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT(2A) receptor activation.
Contreras A, Khumnark M, Hines RM, Hines DJ., Free PMC Article | 09/25/2021 |
| Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. | Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex.
Ju A, Fernandez-Arroyo B, Wu Y, Jacky D, Beyeler A., Free PMC Article | 07/10/2021 |
| Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice. | Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice.
Yang T, Wang H, Li Y, Zeng Z, Shen Y, Wan C, Wu Y, Dong J, Chen L, Wen F. | 01/9/2021 |
| Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling. | Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling.
Plach M, Schäfer T, Borroto-Escuela DO, Weikert D, Gmeiner P, Fuxe K, Friedland K., Free PMC Article | 11/21/2020 |
| Evidence for a molecular basis of gene-environmental interactions was identified in antisocial behavior models and early-life 5-HT2A receptor activation following stress. | Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT(2A) receptor activation.
Godar SC, Mosher LJ, Scheggi S, Devoto P, Moench KM, Strathman HJ, Jones CM, Frau R, Melis M, Gambarana C, Wilkinson B, DeMontis MG, Fowler SC, Coba MP, Wellman CL, Shih JC, Bortolato M., Free PMC Article | 06/27/2020 |
| Study shows that sustained activation of postsynaptic 5-HT2A receptors gates plasticity at prefrontal cortex synapses. findings provide one of the first examples of LTD gating under the control of a G protein-coupled receptor that might lead to imbalanced synaptic plasticity and memory impairment following a nonphysiological elevation of extracellular serotonin. | Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses.
Berthoux C, Barre A, Bockaert J, Marin P, Bécamel C. | 05/23/2020 |
| Peripheral serotonin causes dengue virus-induced thrombocytopenia through 5HT2 receptors. | Peripheral serotonin causes dengue virus-induced thrombocytopenia through 5HT(2) receptors.
Masri MFB, Mantri CK, Rathore APS, John ALS. | 12/28/2019 |
| tph2 C1473 G polymorphism does not alter effects of short-day conditions on immobility time in the forced swim test and the Htr2a mRNA level in the brain. | Effect of photoperiodic alterations on depression-like behavior and the brain serotonin system in mice genetically different in tryptophan hydroxylase 2 activity.
Bazhenova EY, Fursenko DV, Kulikova EA, Khotskin NV, Sinyakova NA, Kulikov AA. | 12/21/2019 |
| HTR2A selectively activates radial glia cells in the developing human, but not mouse, neocortex, and inhibiting HTR2A receptors in human radial glia disrupts the radial glial scaffold. | Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.
Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-Buylla A, Paredes MF, Nowakowski TJ, Pollen AA, Kriegstein AR., Free PMC Article | 11/9/2019 |
| The main finding of the current study was that TC-2153 decreases the functional activity of 5-HT2A receptors in vitro and in vivo. Results demonstrate that TC-2153 can influence the translation and/or stability of 5-HT2A receptors | Inhibitor of Striatal-Enriched Protein Tyrosine Phosphatase, 8-(Trifluoromethyl)-1,2,3,4,5-Benzopentathiepin-6-Amine hydrochloride (TC-2153), Produces Antidepressant-Like Effect and Decreases Functional Activity and Protein Level of 5-HT(2A) Receptor in the Brain.
Kulikova EA, Khotskin NV, Illarionova NB, Sorokin IE, Bazhenova EY, Kondaurova EM, Volcho KP, Khomenko TM, Salakhutdinov NF, Ponimaskin E, Naumenko VS, Kulikov AV. | 03/2/2019 |
| Up-regulation of Htr2a in the hippocampus after maternal separation - early life stress event is associated with vulnerability to excessive voluntary ethanol consumption later in life. | Maternal separation affects expression of stress response genes and increases vulnerability to ethanol consumption.
de Almeida Magalhães T, Correia D, de Carvalho LM, Damasceno S, Brunialti Godard AL., Free PMC Article | 02/9/2019 |
| we showed that gravity changes induced differential modulation of gene expression of BDNF and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes. | Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain.
Ishikawa C, Li H, Ogura R, Yoshimura Y, Kudo T, Shirakawa M, Shiba D, Takahashi S, Morita H, Shiga T., Free PMC Article | 09/16/2017 |
| A pre- and post-synaptic distribution of 5-HT2aRs was found in hippocampus, related to facilitation of object memory. | Examination of the hippocampal contribution to serotonin 5-HT2A receptor-mediated facilitation of object memory in C57BL/6J mice.
Zhang G, Cinalli D, Cohen SJ, Knapp KD, Rios LM, Martínez-Hernández J, Luján R, Stackman RW Jr. | 06/24/2017 |
| these data demonstrate that sustained SERT loss of function reduces 5-HT2AR surface expression that is critical for the synergistic activation of alphaIIbbeta3 by 5-HT and ADP. | Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor.
Oliver KH, Duvernay MT, Hamm HE, Carneiro AM., Free PMC Article | 05/13/2017 |
| heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively. | Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT(2C) protomers.
Moutkine I, Quentin E, Guiard BP, Maroteaux L, Doly S., Free PMC Article | 04/29/2017 |
| In the present study we have demonstrated four new principal facts concerning the role of 5-HT2A receptors in thermoregulation | 5-HT2A receptors control body temperature in mice during LPS-induced inflammation via regulation of NO production.
Voronova IP, Khramova GM, Kulikova EA, Petrovskii DV, Bazovkina DV, Kulikov AV. | 12/17/2016 |