| Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice. | Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.
Zhang W, Shi B, Li S, Liu Z, Li S, Dong S, Cheng Y, Zhu J, Zhang G, Zhong M., Free PMC Article | 01/21/2023 |
| Proteolytic degradation of Hspa2 occurs in response to oxidative stress mediated by 4-hydroxynonenal in male germ cells of the mouse. | Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse.
Bromfield EG, Aitken RJ, McLaughlin EA, Nixon B. | 02/10/2018 |
| a candidate gene approach revealed that HSPA2 is a prominent molecular target of ELAVL1 | The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages.
Chi MN, Auriol J, Jégou B, Kontoyiannis DL, Turner JM, de Rooij DG, Morello D., Free PMC Article | 12/10/2011 |
| NASP controls the ability of HSPA2 to activate CDC2 for CDC2/cyclin B1 complex formation. | Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse.
Alekseev OM, Richardson RT, O'Rand MG., Free PMC Article | 01/21/2010 |
| Hspa2 was detected in central and peripheral nervous system: in neuron's bodies and fiber tracts, in the subventricular zone of the lateral ventricles, in the dentate gyrus of the hippocampus, in enteric ganglia of the gastrointestinal tract | The expression pattern of the 70-kDa heat shock protein Hspa2 in mouse tissues.
Vydra N, Winiarski B, Rak-Raszewska A, Piglowski W, Mazurek A, Scieglinska D, Widlak W. | 01/21/2010 |
| Data show that Parp2 interacts significantly with both the transition protein TP2 and the transition chaperone HSPA2, whereas Parp1 binds weakly to HSPA2. | Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.
Quénet D, Mark M, Govin J, van Dorsselear A, Schreiber V, Khochbin S, Dantzer F. | 01/21/2010 |
| Bat3 is identified as a critical regulator of Hsp70-2 in spermatogenesis, thereby providing a possible molecular target in idiopathic male infertility. | Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis.
Sasaki T, Marcon E, McQuire T, Arai Y, Moens PB, Okada H., Free PMC Article | 01/21/2010 |
| high-level testis-specific gene expression requires additional sequences localized upstream of the T2 transcription start site | Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene.
Scieglińska D, Vydra N, Krawczyk Z, Widłak W., Free PMC Article | 01/21/2010 |
| Data show that NFAT5/TonEBP stimulates transcription of HSP70-2, and is a master regulator of the renal medulla for cellular protection against high osmolality via organic osmolytes and molecular chaperones. | TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity.
Woo SK, Lee SD, Na KY, Park WK, Kwon HM., Free PMC Article | 01/21/2010 |
| Role of Hsp70.2/Hst70 gene in development of the nervous system. | Promoter of the heat shock testis-specific Hsp70.2/Hst70 gene is active in nervous system during embryonic development of mice.
Rupik W, Stawierej A, Stolarczyk I, Widłak W. | 01/21/2010 |
| role for HSPA2, which acquires new functions and becomes tightly associated with major spermatid DNA-packaging proteins, transition proteins 1 and 2 | Post-meiotic shifts in HSPA2/HSP70.2 chaperone activity during mouse spermatogenesis.
Govin J, Caron C, Escoffier E, Ferro M, Kuhn L, Rousseaux S, Eddy EM, Garin J, Khochbin S., Free PMC Article | 01/21/2010 |
| Data show that prior to the onset of massive apoptosis caused by expression of active heat shock transcription factor 1 in spermatocytes a marked reduction in spermatocyte-specific Hsp70.2 mRNA and protein levels occurs. | Heat shock transcription factor 1 down-regulates spermatocyte-specific 70 kDa heat shock protein expression prior to the induction of apoptosis in mouse testes.
Widlak W, Vydra N, Malusecka E, Dudaladava V, Winiarski B, Scieglińska D, Widlak P. | 01/21/2010 |