| Unveiling the regulatory of miR-101-3p on ZNF746 in a Parkinson's disease cell model: Implications for therapeutic targeting. | Unveiling the regulatory of miR-101-3p on ZNF746 in a Parkinson's disease cell model: Implications for therapeutic targeting.
Mahmoudian Esfahani M, Mostashfi M, Vaheb Hosseinabadi S, Hashemi MS, Peymani M, Zohrabi D, Angaji SA, Nasr-Esfahani MH, Ghaedi K. | 06/7/2024 |
| PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification. | PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification.
Kang H, Park S, Jo A, Mao X, Kumar M, Park CH, Ahn JY, Lee Y, Choi JY, Lee YS, Dawson VL, Dawson TM, Kam TI, Shin JH., Free PMC Article | 11/14/2023 |
| ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway. | ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway.
Liu L, Zhao WY, Zheng XY. | 11/8/2023 |
| Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson's Disease in Chinese Population. | Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson's Disease in Chinese Population.
Li CY, Ou RW, Chen YP, Gu XJ, Wei QQ, Cao B, Zhang LY, Hou YB, Liu KC, Chen XP, Song W, Zhao B, Wu Y, Liu Y, Shang HF. | 12/11/2021 |
| ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma. | ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.
Kim H, Lee JY, Park SJ, Kwag E, Koo O, Shin JH. | 11/13/2021 |
| PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency. | PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency.
Pirooznia SK, Yuan C, Khan MR, Karuppagounder SS, Wang L, Xiong Y, Kang SU, Lee Y, Dawson VL, Dawson TM., Free PMC Article | 03/20/2021 |
| PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy. | PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy.
Mukherjee D, Chander V, Bandyopadhyay A., Free PMC Article | 02/13/2021 |
| RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression. | RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.
Nishida T, Yamada Y. | 11/28/2020 |
| We show that parkin is inactivated leading to the accumulation of parkin interacting substrate protein (PARIS) (zinc finger protein 746) (ZNF746) in 3 models of Parkinson's disease | Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.
Brahmachari S, Lee S, Kim S, Yuan C, Karuppagounder SS, Ge P, Shi R, Kim EJ, Liu A, Kim D, Quintin S, Jiang H, Kumar M, Yun SP, Kam TI, Mao X, Lee Y, Swing DA, Tessarollo L, Ko HS, Dawson VL, Dawson TM., Free PMC Article | 05/30/2020 |
| the findings suggest that ZNF746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3beta and F-box/WD repeat-containing protein 7. | Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7.
Jung JH, Jung DB, Kim H, Lee H, Kang SE, Srivastava SK, Yun M, Kim SH. | 03/9/2019 |
| Taken together, these results suggest that PARIS and PIASy modulate PGC-1a gene transcription through distinct molecular mechanisms. | SUMOylation of the KRAB zinc-finger transcription factor PARIS/ZNF746 regulates its transcriptional activity.
Nishida T, Yamada Y. | 05/6/2017 |
| PARIS overexpression leads to reduced mitochondrial number and structural abnormalities | Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.
Stevens DA, Lee Y, Kang HC, Lee BD, Lee YI, Bower A, Jiang H, Kang SU, Andrabi SA, Dawson VL, Shin JH, Dawson TM., Free PMC Article | 01/16/2016 |
| these findings suggest that inhibition of ZNF746 suppresses the invasion and epithelial to mesenchymal transition molecules in H460 NSCLC cells and ZNF746 may be an important target molecule in lung tumorigenesis. | Inhibition of ZNF746 suppresses invasion and epithelial to mesenchymal transition in H460 non-small cell lung cancer cells.
Kim B, Sohn EJ, Jung JH, Shin EA, You OH, Im J, Kim SH. | 09/6/2014 |
| PARIS(ZNF746) is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human PD brain. | PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, Troconso JC, Dawson VL, Dawson TM., Free PMC Article | 04/23/2011 |