| The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons. | The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons.
Chen YJ, Tseng SC, Chen PT, Hwang E., Free PMC Article | 06/30/2024 |
| HMMR triggers immune evasion of hepatocellular carcinoma by inactivation of phagocyte killing. | HMMR triggers immune evasion of hepatocellular carcinoma by inactivation of phagocyte killing.
Wu H, Liu Y, Liu Q, Li Z, Wan Y, Cao C, Wu B, Liu M, Liang R, Hu L, Zhang W, Lan M, Yao Q, Zhou H, Lan H, Chen L, Zhang Y, Zhang X, Bian XW, Xu C., Free PMC Article | 06/13/2024 |
| Single-cell transcriptomic analysis identifies a highly replicating Cd168[+] skeletal stem/progenitor cell population in mouse long bones. | Single-cell transcriptomic analysis identifies a highly replicating Cd168(+) skeletal stem/progenitor cell population in mouse long bones.
Hao RC, Li ZL, Wang FY, Tang J, Li PL, Yin BF, Li XT, Han MY, Mao N, Liu B, Ding L, Zhu H. | 10/11/2023 |
| HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression. | HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H., Free PMC Article | 09/21/2023 |
| Oleate acid-stimulated HMMR expression by CEBPalpha is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma. | Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma.
Zhang D, Liu J, Xie T, Jiang Q, Ding L, Zhu J, Ye Q., Free PMC Article | 04/9/2022 |
| High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate the progression of pancreatic cancer. | High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate the progression of pancreatic cancer.
Lin A, Feng J, Chen X, Wang D, Wong M, Zhang G, Na J, Zhang T, Chen Z, Chen YT, Nancy Du YC., Free PMC Article | 12/25/2021 |
| Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization. | Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization.
Tolg C, Liu M, Cousteils K, Telmer P, Alam K, Ma J, Mendina L, McCarthy JB, Morris VL, Turley EA., Free PMC Article | 12/19/2020 |
| Study provides evidence that RHAMM is a critical component of the inflammatory response, respiratory distress and fibrosis after acute lung injury. | The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury.
Cui Z, Liao J, Cheong N, Longoria C, Cao G, DeLisser HM, Savani RC., Free PMC Article | 08/31/2019 |
| Results showed, for the first time, the distribution and activity of RHAMM in the context of skeletal muscle, and established that CD44 and RHAMM activation promote myogenic and connective tissue migration and proliferation. | Hyaluronic acid, CD44 and RHAMM regulate myoblast behavior during embryogenesis.
Leng Y, Abdullah A, Wendt MK, Calve S., Free PMC Article | 08/31/2019 |
| These data identify an essential role for HMMR in the PLK1-dependent regulatory pathway that orients progenitor cell division and supports neural development. | HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu TL, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel MS, Pilarski LM, Simpson EM, Lange PF, Allan DW, Maxwell CA., Free PMC Article | 06/23/2018 |
| RHAMM localises at the mitotic spindle of ovarian granulosa cells via its C-terminus, deletion of which impairs proper spindle orientation and folliculogenesis. | RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility.
Li H, Moll J, Winkler A, Frappart L, Brunet S, Hamann J, Kroll T, Verlhac MH, Heuer H, Herrlich P, Ploubidou A., Free PMC Article | 10/30/2017 |
| RHAMM is not found on the cell-surface of embryonic stem cells, but it is required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules | The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells.
Jiang J, Mohan P, Maxwell CA., Free PMC Article | 05/17/2014 |
| Hyaluronon acid activation of RHAMM significantly impacts smooth muscle cell-ECM adhesive interactions and contributes to constrictive artery wall remodeling in mice. | Loss of the hyaluronan receptor RHAMM prevents constrictive artery wall remodeling.
Ma X, Pearce JD, Wilson DB, English WP, Edwards MS, Geary RL., Free PMC Article | 05/3/2014 |
| This study demonistrated that Rhamm expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex. | Selective expression of hyaluronan and receptor for hyaluronan mediated motility (Rhamm) in the adult mouse subventricular zone and rostral migratory stream and in ischemic cortex.
Lindwall C, Olsson M, Osman AM, Kuhn HG, Curtis MA. | 09/7/2013 |
| Overexpressing RHAMM was located intracellular and activated ERK1/2. | Overexpression of receptor for hyaluronan-mediated motility (RHAMM) in MC3T3-E1 cells induces proliferation and differentiation through phosphorylation of ERK1/2.
Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, Kamata N. | 11/3/2012 |
| Results suggest that the CD44 and RHAMM receptors function on membrane lipid rafts during Cryptococcus neoformans invasion. | Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection.
Jong A, Wu CH, Gonzales-Gomez I, Kwon-Chung KJ, Chang YC, Tseng HK, Cho WL, Huang SH., Free PMC Article | 08/4/2012 |
| RHAMM isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis. | Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis.
Du YC, Chou CK, Klimstra DS, Varmus H., Free PMC Article | 12/17/2011 |
| intracellular RHAMM(Delta163) functions as an adaptor protein to control microtubule polymerization during interphase and mitosis as a result of localizing ERK1/2-MEK1 complexes to their tubulin-associated substrates | RHAMM promotes interphase microtubule instability and mitotic spindle integrity through MEK1/ERK1/2 activity.
Tolg C, Hamilton SR, Morningstar L, Zhang J, Zhang S, Esguerra KV, Telmer PG, Luyt LG, Harrison R, McCarthy JB, Turley EA., Free PMC Article | 10/4/2010 |
| IHABP/RHAMM mediates cytoplasmic anchoring of the transcription factor Bach1 | Dynamic cytoplasmic anchoring of the transcription factor Bach1 by intracellular hyaluronic acid binding protein IHABP.
Yamasaki C, Tashiro S, Nishito Y, Sueda T, Igarashi K. | 07/7/2008 |
| Androgen receptor regulates CD168 expression and signaling in prostate cancer | Androgen receptor regulates CD168 expression and signaling in prostate cancer.
Lin SL, Chang D, Chiang A, Ying SY. | 01/21/2010 |
| Gene deletion of Rhamm attenuates the formation of aggressive fibromatosis. | Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).
Tolg C, Poon R, Fodde R, Turley EA, Alman BA. | 01/21/2010 |
| CD44 and RHAMM are molecularly redundant and have roles in a model of arthritis and inflammation | RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy.
Nedvetzki S, Gonen E, Assayag N, Reich R, Williams RO, Thurmond RL, Huang JF, Neudecker BA, Wang FS, Turley EA, Naor D., Free PMC Article | 01/21/2010 |