| PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome. | PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.
Mu L, Ye Z, Hu J, Zhang Y, Chen K, Sun H, Li R, Mao W, Long X, Zhang C, Lai Y, Liu J, Zhao Y, Qiao J., Free PMC Article | 10/26/2023 |
| The role of PP5 and PP2C in cardiac health and disease. | The role of PP5 and PP2C in cardiac health and disease.
Neumann J, Boknik P, Kirchhefer U, Gergs U. | 04/9/2022 |
| Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease. | Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.
Hu W, Liu Z, Yu W, Wen S, Wang X, Qi X, Hao H, Lu Y, Li J, Li S, Zhou H., Free PMC Article | 12/25/2021 |
| three Mg(2+) were located in the active site of the PPM1K N94K instead of two Mg(2+) in the PPM1K wild type | Crystal structure and catalytic activity of the PPM1K N94K mutant.
Dolatabad MR, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Liu HD, Shen YM, Yu X, Sun JP, Zhang PJ. | 11/2/2019 |
| Branched chain amino acids related genetic variant rs1440581 was associated with an increased risk of incident T2 Diabetes in a Chinese population. This variant might modify effect of weight gain on development in Insulin resistance. | Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese.
Xuan L, Hou Y, Wang T, Li M, Zhao Z, Lu J, Xu Y, Chen Y, Qi L, Wang W, Bi Y, Xu M. | 09/29/2018 |
| PPM1K rs1440581 may affect changes in glucose metabolism during weight loss, and this effect is dependent on dietary fat and carbohydrate intakes. | Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial.
Goni L, Qi L, Cuervo M, Milagro FI, Saris WH, MacDonald IA, Langin D, Astrup A, Arner P, Oppert JM, Svendstrup M, Blaak EE, Sørensen TI, Hansen T, Martínez JA. | 09/16/2017 |
| miR-204 and miR-211 directly repress PPM1K expression via 3'UTR. | Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells.
Pan BF, Gao C, Ren SX, Wang YB, Sun HP, Zhou MY., Free PMC Article | 08/20/2016 |
| Overweight people with the C allele of the branched-chain amino acid/aromatic amino acid ratio-associated variant rs1440581 may benefit less in weight loss and improved insulin sensitivity than those without it on a energy-restricted high-fat diet. | Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.
Xu M, Qi Q, Liang J, Bray GA, Hu FB, Sacks FM, Qi L., Free PMC Article | 07/6/2013 |
| The 2.4 A PP2Cm structure reveals a central beta-sandwich with two bound metal ions in the active-site cleft. | Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase.
Wynn RM, Li J, Brautigam CA, Chuang JL, Chuang DT., Free PMC Article | 06/16/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Screening for replication of genome-wide SNP associations in sporadic ALS.
Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O., Free PMC Article | 11/19/2008 |
| The cloned phosphatase has a mitochondrial leader sequence and its amino acid sequence places it in the PP2C family like two known mitochondrial phosphatases. | Identification of a novel PP2C-type mitochondrial phosphatase.
Joshi M, Jeoung NH, Popov KM, Harris RA., Free PMC Article | 01/21/2010 |
| A novel member of human protein phosphatase 2C gene family named PP2Ckappa was isolated from a human fetal brain cDNA library. | Characterization of a novel human protein phosphatase 2C family member, PP2Ckappa.
Dai J, Zhang J, Sun Y, Wu Q, Sun L, Ji C, Gu S, Feng C, Xie Y, Mao Y. | 01/21/2010 |