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    AIFM3 AIF family member 3 [ Homo sapiens (human) ]

    Gene ID: 150209, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Bioinformatic Prediction of Novel Signaling Pathways of Apoptosis-inducing Factor, Mitochondrion-associated 3 (AIFM3) and Their Roles in Metastasis of Cholangiocarcinoma Cells.

    Bioinformatic Prediction of Novel Signaling Pathways of Apoptosis-inducing Factor, Mitochondrion-associated 3 (AIFM3) and Their Roles in Metastasis of Cholangiocarcinoma Cells.
    Chua-On D, Proungvitaya T, Techasen A, Limpaiboon T, Roytrakul S, Tummanatsakun D, Araki N, Proungvitaya S., Free PMC Article

    03/12/2022
    CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development.

    CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development.
    Lozic M, Minarik L, Racetin A, Filipovic N, Saraga Babic M, Vukojevic K., Free PMC Article

    10/16/2021
    Apoptosis-Inducing Factor, Mitochondrion-Associated 3 (AIFM3) Protein Level in the Sera as a Prognostic Marker of Cholangiocarcinoma Patients.

    Apoptosis-Inducing Factor, Mitochondrion-Associated 3 (AIFM3) Protein Level in the Sera as a Prognostic Marker of Cholangiocarcinoma Patients.
    Chua-On D, Proungvitaya T, Tummanatsakun D, Techasen A, Limpaiboon T, Roytrakul S, Wongkham S, Wongkham C, Somintara O, Sangkhamanon S, Proungvitaya S., Free PMC Article

    04/17/2021
    AIFM3 was significantly more expressed in breast cancer tissues than in normal tissues. There was a significant association of AIFM3 expression with tumor size, lymph node metastasis, molecular typing and TNM staging. Lymph node metastasis and TNM stage were independent factors of AIFM3 expression. High AIFM3 expression was related to a shorter OS and DFS.

    Clinical implications of a novel prognostic factor AIFM3 in breast cancer patients.
    Zheng A, Zhang L, Song X, Wang Y, Wei M, Jin F., Free PMC Article

    09/14/2019
    Upregulated expression of AIFM3 is associated with cholangiocarcinoma.

    High expression of apoptosis-inducing factor, mitochondrion-associated 3 (AIFM3) in human cholangiocarcinoma.
    Chua-On D, Proungvitaya T, Techasen A, Limpaiboon T, Roytrakul S, Wongkham S, Wongkham C, Somintara O, Sungkhamanon S, Proungvitaya S.

    02/18/2017
    The expression of apoptosis-inducing factor was identified in pineal gland and thymus, but it did not change with age.

    [Expression of AIF and CGRP markers in pineal gland and thymus during aging].
    Lin'kova NS, Katanugina AS, Khavinson VKh.

    06/2/2012
    AIFM3 is a direct target of miR-210 in human hepatoma cells.

    Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro.
    Yang W, Sun T, Cao J, Liu F, Tian Y, Zhu W.

    05/26/2012
    Observational study of gene-disease association. (HuGE Navigator)

    Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article

    12/5/2010
    H. pylori triggers apoptosis in AGS cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c and AIF from mitochondria, and activation of subsequent downstream apoptotic events

    H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria.
    Ashktorab H, Dashwood RH, Dashwood MM, Zaidi SI, Hewitt SM, Green WR, Lee EL, Daremipouran M, Nouraie M, Malekzadeh R, Smoot DT., Free PMC Article

    01/21/2010
    AIF maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function.

    AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells.
    Urbano A, Lakshmanan U, Choo PH, Kwan JC, Ng PY, Guo K, Dhakshinamoorthy S, Porter A., Free PMC Article

    01/21/2010
    AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). AIFL shares 35% homology with AIF, mainly in the Pyr_redox domain.

    Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis.
    Xie Q, Lin T, Zhang Y, Zheng J, Bonanno JA.

    01/21/2010
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