| Role of SIK1 in tumors: Emerging players and therapeutic potentials (Review). | Role of SIK1 in tumors: Emerging players and therapeutic potentials (Review).
Zhang X, Liu J, Zuo C, Peng X, Xie J, Shu Y, Ao D, Zhang Y, Ye Q, Cai J., Free PMC Article | 10/28/2024 |
| Integrated bioinformatics analyses identifying potential biomarkers for type 2 diabetes mellitus and breast cancer: In SIK1-ness and health. | Integrated bioinformatics analyses identifying potential biomarkers for type 2 diabetes mellitus and breast cancer: In SIK1-ness and health.
Durrani IA, Bhatti A, John P., Free PMC Article | 08/11/2023 |
| Down-Regulation and Clinic-Pathological Correlation of SIK-1 and SIL-1-LNC in Non-Small Cell Lung Cancer Patients. | Down-regulation and Clinic-pathological Correlation of SIK-1 and SIK-1-LNC in Non-small Cell Lung Cancer Patients.
Anvarnia A, Panahizadeh R, Zarredar H, Asadi M, Hashemzadeh S, Vatankhah MA, Valizadeh H, Raeisi M., Free PMC Article | 05/3/2023 |
| Exosomal microRNA-25 released from cancer cells targets SIK1 to promote hepatocellular carcinoma tumorigenesis. | Exosomal microRNA-25 released from cancer cells targets SIK1 to promote hepatocellular carcinoma tumorigenesis.
Fu X, Tang Y, Wu W, Ouyang Y, Tan D, Huang Y. | 07/2/2022 |
| Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network. | Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.
Jin Y, Wang H., Free PMC Article | 03/5/2022 |
| Role of SIK1 in the transition of acute kidney injury into chronic kidney disease. | Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Hu J, Qiao J, Yu Q, Liu B, Zhen J, Liu Y, Ma Q, Li Y, Wang Q, Wang C, Lv Z., Free PMC Article | 07/10/2021 |
| SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells. | SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
Wang C, Song D, Fu J, Wen X., Free PMC Article | 05/22/2021 |
| Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis. | Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis.
Huang S, Xue P, Han X, Zhang C, Yang L, Liu L, Wang X, Li H, Fu J, Zhou Y., Free PMC Article | 03/20/2021 |
| Sodium Channel Nav1.5 Controls Epithelial-to-Mesenchymal Transition and Invasiveness in Breast Cancer Cells Through its Regulation by the Salt-Inducible Kinase-1. | Sodium Channel Na(v)1.5 Controls Epithelial-to-Mesenchymal Transition and Invasiveness in Breast Cancer Cells Through its Regulation by the Salt-Inducible Kinase-1.
Gradek F, Lopez-Charcas O, Chadet S, Poisson L, Ouldamer L, Goupille C, Jourdan ML, Chevalier S, Moussata D, Besson P, Roger S., Free PMC Article | 11/21/2020 |
| An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation. | An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.
Murray CW, Brady JJ, Tsai MK, Li C, Winters IP, Tang R, Andrejka L, Ma RK, Kunder CA, Chu P, Winslow MM., Free PMC Article | 08/22/2020 |
| Data suggest that cAMP/protein kinase A-dependent phosphorylation of SIK1, SIK2, and SIK3 inhibits their catalytic activity by inducing 14-3-3 protein binding. | 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).
Sonntag T, Vaughan JM, Montminy M., Free PMC Article | 12/22/2018 |
| This work reveals a regulatory circuit in which SIK1 suppresses gluconeogenic gene transcription by inducing ubiquitination and degradation of CRTC1. | Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1.
Gao WW, Tang HV, Cheng Y, Chan CP, Chan CP, Jin DY. | 06/2/2018 |
| These data suggest that RNF2 is an important upstream negative regulator of SIK1 and that restoration of SIK1 levels induced by loss of RNF2 inhibited HCC cell growth and promoted apoptosis, which may represent a promising therapeutic strategy for HCC treatment. | Down-regulation of salt-inducible kinase 1 (SIK1) is mediated by RNF2 in hepatocarcinogenesis.
Qu C, Qu Y., Free PMC Article | 03/10/2018 |
| Sld5 a component of GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase. | GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication.
Joshi K, Shah VJ, Maddika S. | 09/30/2017 |
| salt-inducible kinase inhibition decreases proinflammatory cytokines in human myeloid cells upon IL-1R stimulation. | SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.
Lombardi MS, Gilliéron C, Dietrich D, Gabay C. | 09/2/2017 |
| SIK1 sequence variation was associated with abnormal neuronal morphology, abnormalities in the MEF2C-ARC pathway of neuronal development and synapse activity. | Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology.
Pröschel C, Hansen JN, Ali A, Tuttle E, Lacagnina M, Buscaglia G, Halterman MW, Paciorkowski AR., Free PMC Article | 07/8/2017 |
| SIK1 plays a vital role in high glucose-induced lipid accumulation, and metformin suppresses lipogenesis via the induction and activation of SIK1. | Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in HepG2 cells and metformin intervention.
Zhang Y, Takemori H, Wang C, Fu J, Xu M, Xiong L, Li N, Wen X. | 03/18/2017 |
| SIK1 was downregulated in ovarian cancer by miR-141. | Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues.
Chen JL, Chen F, Zhang TT, Liu NF. | 03/4/2017 |
| the results showed that miR-203 promotes proliferation, migration and invasion in pancreatic cancer cells, whereas the restoration of SIK1 abrogated the regulation of pre-miR203-mediated proliferation, migration and invasion. | miR-203 promotes proliferation, migration and invasion by degrading SIK1 in pancreatic cancer.
Ren ZG, Dong SX, Han P, Qi J. | 10/29/2016 |
| Results show a role of SIK1 in gastrin induced responses and suggest that SIK1 may act as tumour suppressor in gastric adenocarcinoma cells. | Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells.
Selvik LK, Rao S, Steigedal TS, Haltbakk I, Misund K, Bruland T, Prestvik WS, Lægreid A, Thommesen L., Free PMC Article | 12/19/2015 |
| De novo mutations in SIK1 cause a spectrum of developmental epilepsies. | De novo mutations in SIK1 cause a spectrum of developmental epilepsies.
Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR., Free PMC Article | 05/30/2015 |
| These findings revealed a new function of LKB1 and salt-inducible kinases as negative regulators of HTLV-1 transcription. | LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription.
Tang HM, Gao WW, Chan CP, Siu YT, Wong CM, Kok KH, Ching YP, Takemori H, Jin DY., Free PMC Article | 09/21/2013 |
| SIK1 is required for myogenic differentiation; it's transcriptional regulation and regulated degradation comprise a unified molecular mechanism to precisely tune SIK1 activity in muscle cells. | Regulation of SIK1 abundance and stability is critical for myogenesis.
Stewart R, Akhmedov D, Robb C, Leiter C, Berdeaux R., Free PMC Article | 03/2/2013 |
| High SIK gene expression is assiciated with glioblastoma multiforme. | Integration of global spectral karyotyping, CGH arrays, and expression arrays reveals important genes in the pathogenesis of glioblastoma multiforme.
Leone PE, González MB, Elosua C, Gómez-Moreta JA, Lumbreras E, Robledo C, Santos-Briz A, Valero JM, de la Guardia RD, Gutiérrez NC, Hernández JM, García JL. | 10/27/2012 |
| We now demonstrate that TGFbeta induces SIK1 levels via a direct transcriptional mechanism that implicates the Smad proteins, and we have mapped a putative enhancer element on the SIK1 gene. | Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
Lönn P, Vanlandewijck M, Raja E, Kowanetz M, Watanabe Y, Kowanetz K, Vasilaki E, Heldin CH, Moustakas A., Free PMC Article | 06/23/2012 |