| Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity. | Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity.
Nabit BP, Taylor A, Winder DG., | 09/10/2024 |
| Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation. | Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation.
Woo MS, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, Sonner JK, Engler JB, Hornig S, Bauer S, Wagner I, Egervari K, Raber J, Duvoisin RM, Pless O, Merkler D, Friese MA., Free PMC Article | 10/9/2021 |
| Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum. | Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum.
Katona L, Hartwich K, Tomioka R, Somogyi J, Roberts JDB, Wagner K, Joshi A, Klausberger T, Rockland KS, Somogyi P., Free PMC Article | 11/21/2020 |
| the data of this study revealed very different roles for mGlu8 in amygdala synaptic transmission, fear learning and its expression | Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology.
Fendt M, Imobersteg S, Peterlik D, Chaperon F, Mattes C, Wittmann C, Olpe HR, Mosbacher J, Vranesic I, van der Putten H, McAllister KH, Flor PJ, Gee CE. | 02/15/2014 |
| In the dentate gyrus of mGluR8 receptor-deficient mice, effects from selective agonists are linked to the lateral and medial perforant pathway. | Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.
Mercier MS, Lodge D, Fang G, Nicolas CS, Collett VJ, Jane DE, Collingridge GL, Bortolotto ZA. | 11/16/2013 |
| mGluR8 is an important regulator of excitatory transmission in the bed nucleus of the stria terminalis, and is selectively disrupted by both acute and chronic stress. | mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.
Gosnell HB, Silberman Y, Grueter BA, Duvoisin RM, Raber J, Winder DG., Free PMC Article | 03/24/2012 |
| mGluR8 deficiency decreased measures of anxiety in the elevated plus maze and the acoustic startle response in female mice. | Sex-dependent cognitive phenotype of mice lacking mGluR8.
Duvoisin RM, Villasana L, Pfankuch T, Raber J., Free PMC Article | 05/31/2010 |
| Might be potential target for disorders with pathophysiological changes in brain areas where mGlu8 modulates glutamate and GABA transmission, especially in anxiety disorders involving exaggerated contextual fear. | The effect of mGlu8 deficiency in animal models of psychiatric diseases.
Fendt M, Bürki H, Imobersteg S, van der Putten H, McAllister K, Leslie JC, Shaw D, Hölscher C. | 05/10/2010 |
| mGluR8 was localized in two broad bands, one each in the OFF and ON layers of the IPL; mGluR8 immunoreactivity was evident in the OFF plexus of cholinergic amacrine cell processes | Distribution of group-III metabotropic glutamate receptors in the retina.
Quraishi S, Gayet J, Morgans CW, Duvoisin RM. | 01/21/2010 |
| Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8. | Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8.
Duvoisin RM, Zhang C, Pfankuch TF, O'Connor H, Gayet-Primo J, Quraishi S, Raber J. | 01/21/2010 |
| Naive mGlu8 receptor-deficient mice show increased anxiety-related behavior in the elevated plus maze in low illumination conditions (red light) compared to wild-type mice. | Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor.
Linden AM, Johnson BG, Peters SC, Shannon HE, Tian M, Wang Y, Yu JL, Köster A, Baez M, Schoepp DD. | 01/21/2010 |
| The role of mGluR8 as a presynaptic autoreceptor and its contribution to cognitive processes are hypothesized and the utility of gene targeting is discussed as compared to pharmacological methods. | Performance deficits of mGluR8 knockout mice in learning tasks: the effects of null mutation and the background genotype.
Gerlai R, Adams B, Fitch T, Chaney S, Baez M. | 01/21/2010 |
| The increased anxiety-related behavior of mGlu8 receptor knockout mice in the elevated plus maze is associated with an increased number of c-Fos positive cells in the centromedial nucleus of the thalamus compared with wild-type mice. | Increased c-Fos expression in the centromedial nucleus of the thalamus in metabotropic glutamate 8 receptor knockout mice following the elevated plus maze test.
Linden AM, Baez M, Bergeron M, Schoepp DD. | 01/21/2010 |