| Hypothalamic Grb10 enhances leptin signalling and promotes weight loss. | Hypothalamic Grb10 enhances leptin signalling and promotes weight loss.
Liu H, He Y, Bai J, Zhang C, Zhang F, Yang Y, Luo H, Yu M, Liu H, Tu L, Zhang N, Yin N, Han J, Yan Z, Scarcelli NA, Conde KM, Wang M, Bean JC, Potts CHS, Wang C, Hu F, Liu F, Xu Y. | 02/11/2023 |
| GRB10 regulates beta-cell mass by inhibiting beta-cell proliferation and stimulating beta-cell dedifferentiation. | GRB10 regulates β-cell mass by inhibiting β-cell proliferation and stimulating β-cell dedifferentiation.
Cai Z, Liu F, Yang Y, Li D, Hu S, Song L, Yu S, Li T, Liu B, Luo H, Zhang W, Zhou Z, Zhang J. | 04/16/2022 |
| Mice lacking paternal expression of imprinted Grb10 are risk-takers. | Mice lacking paternal expression of imprinted Grb10 are risk-takers.
Dent CL, Rienecker KDA, Ward A, Wilkins JF, Humby T, Isles AR., Free PMC Article | 07/17/2021 |
| Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance. | Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance.
Rienecker KDA, Chavasse AT, Moorwood K, Ward A, Isles AR., Free PMC Article | 02/6/2021 |
| Grb10 gene could be reactivated in adult mouse liver by acute endoplasmic reticulum stress. | De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver.
Luo L, Jiang W, Liu H, Bu J, Tang P, Du C, Xu Z, Luo H, Liu B, Xiao B, Zhou Z, Liu F. | 09/14/2019 |
| ablation of growth factor receptor bound protein 10 (Grb10) in muscle is sufficient to affect muscle size and metabolism, supporting an important role for this protein in growth and metabolic pathways | Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice.
Holt LJ, Brandon AE, Small L, Suryana E, Preston E, Wilks D, Mokbel N, Coles CA, White JD, Turner N, Daly RJ, Cooney GJ. | 11/10/2018 |
| DNA methylation at CpG island 1 (CGI1) of Grb10 in blastocysts were also significantly decreased after vitrification | Effect of vitrification on in vitro development and imprinted gene Grb10 in mouse embryos.
Yao J, Geng L, Huang R, Peng W, Chen X, Jiang X, Yu M, Li M, Huang Y, Yang X. | 04/28/2018 |
| This study reveals a function for the imprinted gene Grb10 in regulating hematopoietic stem cell self-renewal. | Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP., Free PMC Article | 11/26/2017 |
| In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development. | Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.
Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL., Free PMC Article | 04/30/2016 |
| This study identified Grb10 as a critical regulator of lipid metabolism, the programming of the browning phenotype, and thermogenesis in adipose tissues. | Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.
Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu Y, Zhou Z, Blenis J, Scherer PE, Dong LQ, Liu F., Free PMC Article | 06/20/2015 |
| Negative regulation of Grb10 Interacting GIGYF2 protein on IGF-1 receptor signaling pathway caused diabetic mice cognitive impairment. | Negative regulation of Grb10 Interacting GYF Protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairment.
Xie J, Wei Q, Deng H, Li G, Ma L, Zeng H., Free PMC Article | 06/20/2015 |
| Grb10 is involved in BCR-ABL-positive leukemia in mice. | Grb10 is involved in BCR-ABL-positive leukemia in mice.
Illert AL, Albers C, Kreutmair S, Leischner H, Peschel C, Miething C, Duyster J. | 06/6/2015 |
| Grb10 is a key genetic component of developmental programming. | Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.
Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ, Kendrick H, Isles AR, Parry AJ, Carney S, Oakey RJ, Heisler LK, Moorwood K, Wolf JB, Ward A., Free PMC Article | 10/18/2014 |
| Glucose uptake was higher in Grb10(-/-) primary myotubes in the basal state and was associated with enhanced insulin signaling and an increase in GLUT4 translocation to the plasma membrane. | Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation.
Mokbel N, Hoffman NJ, Girgis CM, Small L, Turner N, Daly RJ, Cooney GJ, Holt LJ. | 09/27/2014 |
| Grb10 expression in mouse embryo is regulated by Lmx1a transcription factor. | Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.
Hoekstra EJ, von Oerthel L, van der Linden AJ, Schellevis RD, Scheppink G, Holstege FC, Groot-Koerkamp MJ, van der Heide LP, Smidt MP. | 06/15/2013 |
| Results suggest consecutive passaging may affect epigenetic modifications of Grb10 in adult fibroblast cells. | Epigenetic modifications and mRNA levels of the imprinted gene Grb10 in serially passaged fibroblast cells.
Yao J, Huang Y, Huang R, Shi R, Chen P, Zhu B, Li M, Jiang X, Zheng M, Jiang Y, Yang X. | 03/9/2013 |
| Study has identified Grb10 as an important regulator of beta-cell proliferation and demonstrated that reducing the expression level of Grb10 could provide a novel means to increase beta-cell mass and reduce beta-cell apoptosis. | Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis.
Zhang J, Zhang N, Liu M, Li X, Zhou L, Huang W, Xu Z, Liu J, Musi N, DeFronzo RA, Cunningham JM, Zhou Z, Lu XY, Liu F., Free PMC Article | 01/26/2013 |
| Grb10-ablated muscle from adult mice shows coordinate gene changes that oppose those of muscle wasting pathologies, highlighting Grb10 as a potential therapeutic target for these conditions | Grb10 regulates the development of fiber number in skeletal muscle.
Holt LJ, Turner N, Mokbel N, Trefely S, Kanzleiter T, Kaplan W, Ormandy CJ, Daly RJ, Cooney GJ. | 12/29/2012 |
| Data suggest that GRB10 is involved in pancreatic alpha cell survival and, as result, plays an important role in regulating basal glucagon secretion and glucose tolerance; studies include both apoptotic and anti-apoptotic signaling of GRB10. | Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels.
Doiron B, Hu W, Norton L, DeFronzo RA. | 07/21/2012 |
| mTORC1-mediated phosphorylation stabilized Grb10, leading to feedback inhibition of the phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways | Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J., Free PMC Article | 06/25/2011 |
| analysis of the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4 | Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4.
Huang Q, Szebenyi DM., Free PMC Article | 02/26/2011 |
| Grb10 is, so far, a unique imprinted gene, able to influence distinct physiological processes, fetal growth and adult behaviour, owing to actions of the two parental alleles in different tissues | Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.
Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR, Ward A., Free PMC Article | 02/5/2011 |
| Grb10 gene is expressed from the paternal allele in brain, but from the maternal allele in most other tissues. | Role of DNA methylation and histone H3 lysine 27 methylation in tissue-specific imprinting of mouse Grb10.
Yamasaki-Ishizaki Y, Kayashima T, Mapendano CK, Soejima H, Ohta T, Masuzaki H, Kinoshita A, Urano T, Yoshiura K, Matsumoto N, Ishimaru T, Mukai T, Niikawa N, Kishino T., Free PMC Article | 11/12/2010 |
| Grb10 can influence reproductive strategy through the allocation of maternal resources such that offspring number is offset against size. | Maternally-inherited Grb10 reduces placental size and efficiency.
Charalambous M, Cowley M, Geoghegan F, Smith FM, Radford EJ, Marlow BP, Graham CF, Hurst LD, Ward A. | 01/21/2010 |
| Grb10 and Grb14 have roles in regulation of insulin signaling and glucose homeostasis | Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis.
Holt LJ, Lyons RJ, Ryan AS, Beale SM, Ward A, Cooney GJ, Daly RJ., Free PMC Article | 01/21/2010 |