| G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model. | G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model.
Huang Y, Rafael Guimarães T, Todd N, Ferguson C, Weiss KM, Stauffer FR, McDermott B, Hurtle BT, Saito T, Saido TC, MacDonald ML, Homanics GE, Thathiah A., Free PMC Article | 10/15/2022 |
| GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice. | GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice.
Masuda S, Tanaka S, Shiraki H, Sotomaru Y, Harada K, Hide I, Kiuchi Y, Sakai N. | 09/3/2022 |
| GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons. | GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons.
Tanaka S, Shimada N, Shiraki H, Miyagi T, Harada K, Hide I, Sakai N. | 05/7/2022 |
| Potential role of inducible GPR3 expression under stimulated T cell conditions. | Potential role of inducible GPR3 expression under stimulated T cell conditions.
Shiraki H, Tanaka S, Guo Y, Harada K, Hide I, Yasuda T, Sakai N. | 02/26/2022 |
| Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. | Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Sveidahl Johansen O, Ma T, Hansen JB, Markussen LK, Schreiber R, Reverte-Salisa L, Dong H, Christensen DP, Sun W, Gnad T, Karavaeva I, Nielsen TS, Kooijman S, Cero C, Dmytriyeva O, Shen Y, Razzoli M, O'Brien SL, Kuipers EN, Nielsen CH, Orchard W, Willemsen N, Jespersen NZ, Lundh M, Sustarsic EG, Hallgren CM, Frost M, McGonigle S, Isidor MS, Broholm C, Pedersen O, Hansen JB, Grarup N, Hansen T, Kjær A, Granneman JG, Babu MM, Calebiro D, Nielsen S, Rydén M, Soccio R, Rensen PCN, Treebak JT, Schwartz TW, Emanuelli B, Bartolomucci A, Pfeifer A, Zechner R, Scheele C, Mandrup S, Gerhart-Hines Z., Free PMC Article | 01/8/2022 |
| Detailed neuronal distribution of GPR3 and its co-expression with EF-hand calcium-binding proteins in the mouse central nervous system. | Detailed neuronal distribution of GPR3 and its co-expression with EF-hand calcium-binding proteins in the mouse central nervous system.
Ikawa F, Tanaka S, Harada K, Hide I, Maruyama H, Sakai N. | 11/27/2021 |
| These results demonstrate that GPR3 potentiates meiotic competence, most likely by raising cAMP. | The switch from cAMP-independent to cAMP-dependent arrest of meiotic prophase is associated with coordinated GPR3 and CDK1 expression in mouse oocytes.
Firmani LD, Uliasz TF, Mehlmann LM. | 03/31/2018 |
| GPR3 appears to have a key role in the thermogenic response of interscapular brown adipose tissue and may represent a new therapeutic target in age-related obesity. | Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.
Godlewski G, Jourdan T, Szanda G, Tam J, Cinar R, Harvey-White J, Liu J, Mukhopadhyay B, Pacher P, Ming Mo F, Osei-Hyiaman D, Kunos G., Free PMC Article | 08/27/2016 |
| This study found that the expression of GPR3 in CGNs exerted prosurvival effects against apoptosis-inducing stimuli, such as potassium deprivation, hypoxia, and ROS. | Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli.
Tanaka S, Miyagi T, Dohi E, Seki T, Hide I, Sotomaru Y, Saeki Y, Antonio Chiocca E, Matsumoto M, Sakai N. | 05/16/2015 |
| Altered signalling pathways of GPR3 could contribute to the neurobiological substrate involved in developing addiction to cocaine | The orphan receptor GPR3 modulates the early phases of cocaine reinforcement.
Tourino C, Valjent E, Ruiz-Medina J, Herve D, Ledent C, Valverde O., Free PMC Article | 02/16/2013 |
| Involvement of the orphan GPR3 receptor is demonstrated for the first time in expression and development of neuropathic pain and in analgesia induced by morphine. | GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception.
Ruiz-Medina J, Ledent C, Valverde O. | 04/21/2012 |
| GPR3 is a novel antiproliferative mediator of CGPs in the postnatal development of murine cerebellu | The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development.
Tanaka S, Shaikh IM, Chiocca EA, Saeki Y., Free PMC Article | 01/21/2010 |
| GPR3 qualifies as a new player in the modulation of behavioral responses to stress and constitutes a novel promising pharmacological target for treatment of emotional disorders | GPR3 receptor, a novel actor in the emotional-like responses.
Valverde O, Célérier E, Baranyi M, Vanderhaeghen P, Maldonado R, Sperlagh B, Vassart G, Ledent C., Free PMC Article | 01/21/2010 |
| Gpr3 is epistatic to Pde3a and fertility as well as meiotic arrest in the PDE3A-deficient oocyte is dependent on the activity of GPR3. | Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest.
Vaccari S, Horner K, Mehlmann LM, Conti M., Free PMC Article | 01/21/2010 |
| GPR3-G(s) activation in response to stimulation of an exogenously expressed beta(2)-adrenergic receptor causes Galpha(s) to move from the oocyte plasma membrane into the cytoplasm. | A G(s)-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-G(s) signaling.
Norris RP, Freudzon L, Freudzon M, Hand AR, Mehlmann LM, Jaffe LA., Free PMC Article | 01/21/2010 |
| the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12 | The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes.
Hinckley M, Vaccari S, Horner K, Chen R, Conti M. | 01/21/2010 |
| the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis | The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes.
Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA. | 01/21/2010 |
| Gpr3-defective mice may constitute a relevant model of premature ovarian failure due to early oocyte aging. | Premature ovarian aging in mice deficient for Gpr3.
Ledent C, Demeestere I, Blum D, Petermans J, Hämäläinen T, Smits G, Vassart G., Free PMC Article | 01/21/2010 |
| GPR3 specifically in the oocyte, rather than in the follicle cells, is responsible for maintenance of meiotic arrest in mouse oocytes. | Oocyte-specific expression of Gpr3 is required for the maintenance of meiotic arrest in mouse oocytes.
Mehlmann LM., Free PMC Article | 01/21/2010 |