| SARS-CoV-2 infection causes a decline in renal megalin expression and affects vitamin D metabolism in the kidney of K18-hACE2 mice. | SARS-CoV-2 infection causes a decline in renal megalin expression and affects vitamin D metabolism in the kidney of K18-hACE2 mice.
Kurosaki Y, Matsumoto T, Uematsu T, Kawakami F, Kawashima R, Tamaki S, Imai M, Ichikawa T, Ishii N, Kitasato H, Hanaki H, Kubo M., Free PMC Article | 10/25/2024 |
| Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia. | Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia.
Takano-Kawabe K, Matoba K, Nakamura Y, Moriyama M. | 01/10/2024 |
| Megalin is involved in angiotensinogen-induced, angiotensin II-mediated ERK1/2 signaling to activate Na + -H + exchanger 3 in proximal tubules. | Megalin is involved in angiotensinogen-induced, angiotensin II-mediated ERK1/2 signaling to activate Na + -H + exchanger 3 in proximal tubules.
Goto S, Yoshida Y, Hosojima M, Kuwahara S, Kabasawa H, Aoki H, Iida T, Sawada R, Ugamura D, Yoshizawa Y, Takemoto K, Komochi K, Kobayashi R, Kaseda R, Yaoita E, Nagatoishi S, Narita I, Tsumoto K, Saito A. | 10/10/2023 |
| Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome. | Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome.
Skeby CK, Hummelgaard S, Gustafsen C, Petrillo F, Frederiksen KP, Olsen D, Kristensen T, Ivarsen P, Madsen P, Christensen EI, Nielsen R, Birn H, Glerup S, Weyer K. | 09/25/2023 |
| Variants of LRP2, encoding a multifunctional cell-surface endocytic receptor, associated with hearing loss and retinal dystrophy. | Variants of LRP2, encoding a multifunctional cell-surface endocytic receptor, associated with hearing loss and retinal dystrophy.
Faridi R, Yousaf R, Gu S, Inagaki S, Turriff AE, Pelstring K, Guan B, Naik A, Griffith AJ, Adadey SM, Aboagye ET, Awandare GA, Morell RJ, Tsilou E, Noyes AG, Sulmonte LAG, Wonkam A, Schrauwen I, Leal SM, Azaiez H, Brewer CC, Riazuddin S, Hufnagel RB, Hoa M, Zein WM, de Dios JK, Friedman TB., Free PMC Article | 08/25/2023 |
| LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function. | LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function.
Bunatyan L, Margineanu A, Boutin C, Montcouquiol M, Bachmann S, Ilsø Christensen E, Willnow TE, Christ A., Free PMC Article | 08/25/2023 |
| Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells. | Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells.
Rbaibi Y, Long KR, Shipman KE, Ren Q, Baty CJ, Kashlan OB, Weisz OA., Free PMC Article | 05/22/2023 |
| Structures of LRP2 reveal a molecular machine for endocytosis. | Structures of LRP2 reveal a molecular machine for endocytosis.
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L., Free PMC Article | 02/24/2023 |
| An Adaptable Physiological Model of Endocytic Megalin Trafficking in Opossum Kidney Cells and Mouse Kidney Proximal Tubule. | An Adaptable Physiological Model of Endocytic Megalin Trafficking in Opossum Kidney Cells and Mouse Kidney Proximal Tubule.
Shipman KE, Long KR, Cowan IA, Rbaibi Y, Baty CJ, Weisz OA., Free PMC Article | 01/14/2023 |
| Postnatal eye size in mice is controlled by SREBP2-mediated transcriptional repression of Lrp2 and Bmp2. | Postnatal eye size in mice is controlled by SREBP2-mediated transcriptional repression of Lrp2 and Bmp2.
Mai S, Zhu X, Wan EYC, Wu S, Yonathan JN, Wang J, Li Y, Ma JYW, Zuo B, Tse DY, Lo PC, Wang X, Chan KM, Wu DM, Xiong W., Free PMC Article | 07/23/2022 |
| Mettl3-mediated m(6) A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects. | Mettl3-mediated m(6) A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects.
Xu B, Li Q, Wu Y, Wang H, Xu J, Liu H, Xuan A. | 07/2/2022 |
| Albumin Expands Albumin Reabsorption Capacity in Proximal Tubule Epithelial Cells through a Positive Feedback Loop between AKT and Megalin. | Albumin Expands Albumin Reabsorption Capacity in Proximal Tubule Epithelial Cells through a Positive Feedback Loop between AKT and Megalin.
Silva-Aguiar RP, Peruchetti DB, Florentino LS, Takiya CM, Marzolo MP, Dias WB, Pinheiro AAS, Caruso-Neves C., Free PMC Article | 02/12/2022 |
| Long non-coding RNA AC012668 suppresses non-alcoholic fatty liver disease by competing for microRNA miR-380-5p with lipoprotein-related protein LRP2. | Long non-coding RNA AC012668 suppresses non-alcoholic fatty liver disease by competing for microRNA miR-380-5p with lipoprotein-related protein LRP2.
Chen X, Ma H, Gao Y, Jin Y, Ning W, Hou Y, Su J., Free PMC Article | 01/22/2022 |
| Cilastatin Ameliorates Rhabdomyolysis-induced AKI in Mice. | Cilastatin Ameliorates Rhabdomyolysis-induced AKI in Mice.
Matsushita K, Mori K, Saritas T, Eiwaz MB, Funahashi Y, Nickerson MN, Hebert JF, Munhall AC, McCormick JA, Yanagita M, Hutchens MP., Free PMC Article | 12/11/2021 |
| Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects. | Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.
Arrigo AB, Lin JI., Free PMC Article | 09/18/2021 |
| LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation. | LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation.
Christ A, Marczenke M, Willnow TE., Free PMC Article | 09/4/2021 |
| Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity? | Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
Sandin ES, Folberth J, Müller-Fielitz H, Pietrzik CU, Herold E, Willnow TE, Pfluger PT, Nogueiras R, Prevot V, Krey T, Schwaninger M., Free PMC Article | 06/19/2021 |
| Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds. | Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds.
Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Görne J, Wallingford JB, Hammes A, Feistel K., Free PMC Article | 04/24/2021 |
| Megalin-mediated albumin endocytosis in cultured murine mesangial cells. | Megalin-mediated albumin endocytosis in cultured murine mesangial cells.
Bryniarski MA, Yee BM, Chaves LD, Stahura CM, Yacoub R, Morris ME. | 02/13/2021 |
| Sodium-glucose cotransporter 2 inhibition attenuates protein overload in renal proximal tubule via suppression of megalin O-GlcNacylation in progressive diabetic nephropathy. | Sodium-glucose cotransporter 2 inhibition attenuates protein overload in renal proximal tubule via suppression of megalin O-GlcNacylation in progressive diabetic nephropathy.
Otomo H, Nara M, Kato S, Shimizu T, Suganuma Y, Sato T, Morii T, Yamada Y, Fujita H. | 12/26/2020 |
| Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease. | Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease.
Charlton JR, Tan W, Daouk G, Teot L, Rosen S, Bennett KM, Cwiek A, Nam S, Emma F, Jouret F, Oliveira JP, Tranebjærg L, Frykholm C, Mane S, Hildebrandt F, Srivastava T, Storm T, Christensen EI, Nielsen R., Free PMC Article | 12/19/2020 |
| Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge. | Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge.
Bartolome F, Antequera D, de la Cueva M, Rubio-Fernandez M, Castro N, Pascual C, Camins A, Carro E., Free PMC Article | 11/21/2020 |
| In proximal kidney tubules megalin binding to albumin is of lower affinity, and its expression is also essential for enabling the recovery of high concentrations of albumin in the fluid phase. | Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin.
Ren Q, Weyer K, Rbaibi Y, Long KR, Tan RJ, Nielsen R, Christensen EI, Baty CJ, Kashlan OB, Weisz OA., Free PMC Article | 07/18/2020 |
| a key role of the megalin/LRP2 pathway in the progression of nephropathic cystinosis. | Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression.
Janssens V, Gaide Chevronnay HP, Marie S, Vincent MF, Van Der Smissen P, Nevo N, Vainio S, Nielsen R, Christensen EI, Jouret F, Antignac C, Pierreux CE, Courtoy PJ., Free PMC Article | 06/6/2020 |
| Megalin in Galnt11-deficient mice displays reduced ligand binding and undergoes age-related loss within the kidney. | Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.
Tian E, Wang S, Zhang L, Zhang Y, Malicdan MC, Mao Y, Christoffersen C, Tabak LA, Schjoldager KT, Ten Hagen KG., Free PMC Article | 05/2/2020 |