| GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO INHIBIT FERROPTOSIS. | GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO INHIBIT FERROPTOSIS.
Wu Z, Xi Q, Zhao Q, Zhu S. | 08/15/2024 |
| GDF11 mitigates high glucose-induced cardiomyocytes apoptosis by inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway. | GDF11 mitigates high glucose-induced cardiomyocytes apoptosis by inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway.
Shao Y, Li M, Wang Y, Qu Y, Gong M, Yu Q, Yang X, Liu D, Li H, Wang Y, Sun H, Zhang Y, Zhang X, Liu T, Liu J, Gong T, Sun Y, Du Z, Jiao L, Zhang Y. | 03/5/2024 |
| Silencing of GDF11 suppresses hepatocyte apoptosis to relieve LPS/D-GalN acute liver failure. | Silencing of GDF11 suppresses hepatocyte apoptosis to relieve LPS/D-GalN acute liver failure.
Zhou R, Li S, Wang Q, Bi Y, Li X, Wang Q. | 01/26/2024 |
| Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans. | Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans.
Kraler S, Balbi C, Vdovenko D, Lapikova-Bryhinska T, Camici GG, Liberale L, Bonetti N, Canestro CD, Burger F, Roth A, Carbone F, Vassalli G, Mach F, Bhasin S, Wenzl FA, Muller O, Räber L, Matter CM, Montecucco F, Lüscher TF, Akhmedov A., Free PMC Article | 01/13/2024 |
| Growth differentiation factor 11 suppresses intrahepatic inflammation via restricting NLRP3 inflammasome activation in LPS-induced liver injury. | Growth differentiation factor 11 suppresses intrahepatic inflammation via restricting NLRP3 inflammasome activation in LPS-induced liver injury.
Huang H, Wu S, Yan Y. | 01/4/2024 |
| Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy. | Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy.
Moigneu C, Abdellaoui S, Ramos-Brossier M, Pfaffenseller B, Wollenhaupt-Aguiar B, de Azevedo Cardoso T, Camus C, Chiche A, Kuperwasser N, Azevedo da Silva R, Pedrotti Moreira F, Li H, Oury F, Kapczinski F, Lledo PM, Katsimpardi L., Free PMC Article | 05/3/2023 |
| MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function. | MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function.
Bajikar SS, Anderson AG, Zhou J, Durham MA, Trostle AJ, Wan YW, Liu Z, Zoghbi HY., Free PMC Article | 03/1/2023 |
| Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle. | Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
Lian J, Walker RG, D'Amico A, Vujic A, Mills MJ, Messemer KA, Mendello KR, Goldstein JM, Leacock KA, Epp S, Stimpfl EV, Thompson TB, Wagers AJ, Lee RT., Free PMC Article | 02/10/2023 |
| GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/beta-catenin and ALK5/SMAD2/3 pathways. | GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β-catenin and ALK5/SMAD2/3 pathways.
Frohlich J, Kovacovicova K, Raffaele M, Virglova T, Cizkova E, Kucera J, Bienertova-Vasku J, Wabitsch M, Peyrou M, Bonomini F, Rezzani R, Chaldakov GN, Tonchev AB, Di Rosa M, Blavet N, Hejret V, Vinciguerra M., Free PMC Article | 10/8/2022 |
| Neuroprotective effects of TRPV1 by targeting GDF11 in the Mpp+/MPTP-induced Parkinson's disease model. | Neuroprotective effects of TRPV1 by targeting GDF11 in the Mpp+/MPTP-induced Parkinson's disease model.
Zhang K, Liu P, Yuan L, Geng Z, Li B, Zhang B. | 08/27/2022 |
| GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFbetaR1/SMAD-2 pathway. | GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFβR1/SMAD-2 pathway.
Duan F, Wang X, Wang H, Wang Y, Zhang Y, Chen J, Zhu X, Chen B. | 06/25/2022 |
| GDF11 protects against glucotoxicity-induced mice retinal microvascular endothelial cell dysfunction and diabetic retinopathy disease. | GDF11 protects against glucotoxicity-induced mice retinal microvascular endothelial cell dysfunction and diabetic retinopathy disease.
Mei W, Zhu B, Shu Y, Liang Y, Lin M, He M, Luo H, Ye J. | 03/26/2022 |
| GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis. | GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis.
Mayweather BA, Buchanan SM, Rubin LL., Free PMC Article | 02/5/2022 |
| A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin. | A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin.
Starcher AE, Peissig K, Stanton JB, Churchill GA, Cai D, Maxwell JT, Grider A, Love K, Chen SY, Coleman AE, Strauss E, Pazdro R., Free PMC Article | 01/15/2022 |
| Growth differentiation factor 11 mitigates cardiac radiotoxicity via activating AMPKalpha. | Growth differentiation factor 11 mitigates cardiac radiotoxicity via activating AMPKα.
Li X, Ding D, Chen W, Liu Y, Pan H, Hu J. | 12/18/2021 |
| Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity. | Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity.
Chen L, Luo G, Liu Y, Lin H, Zheng C, Xie D, Zhu Y, Chen L, Huang X, Hu D, Xie J, Chen Z, Liao W, Bin J, Wang Q, Liao Y., Free PMC Article | 09/25/2021 |
| BMP11 regulates thermogenesis in white and brown adipocytes. | BMP11 regulates thermogenesis in white and brown adipocytes.
Pham HG, Mukherjee S, Choi MJ, Yun JW. | 07/10/2021 |
| Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia. | Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia.
Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler JL, Eng KH, Chakkalakal JV, Krolewski JJ, Nastiuk KL., Free PMC Article | 05/22/2021 |
| PPARalpha Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model. | PPARα Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model.
Dou F, Wu B, Chen J, Liu T, Yu Z, Chen C., Free PMC Article | 05/22/2021 |
| Growth differentiation factor 11 promotes differentiation of MSCs into endothelial-like cells for angiogenesis. | Growth differentiation factor 11 promotes differentiation of MSCs into endothelial-like cells for angiogenesis.
Zhang C, Lin Y, Liu Q, He J, Xiang P, Wang D, Hu X, Chen J, Zhu W, Yu H., Free PMC Article | 05/15/2021 |
| Endogenous GDF11 regulates odontogenic differentiation of dental pulp stem cells. | Endogenous GDF11 regulates odontogenic differentiation of dental pulp stem cells.
Qi X, Xiao Q, Sheng R, Jiang S, Yuan Q, Liu W., Free PMC Article | 05/8/2021 |
| Growth differentiation factor 11 relieves acute lung injury in mice by inhibiting inflammation and apoptosis. | Growth differentiation factor 11 relieves acute lung injury in mice by inhibiting inflammation and apoptosis.
Xu HB, Qin B, Zhang J, Chen YJ, Shen WW, Cao LN. | 05/8/2021 |
| Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe? | Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?
Frohlich J, Vinciguerra M., Free PMC Article | 05/1/2021 |
| Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice. | Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice.
Katsimpardi L, Kuperwasser N, Camus C, Moigneu C, Chiche A, Tolle V, Li H, Kokovay E, Lledo PM., Free PMC Article | 01/16/2021 |
| GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone. | GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone.
Suh J, Kim NK, Lee SH, Eom JH, Lee Y, Park JC, Woo KM, Baek JH, Kim JE, Ryoo HM, Lee SJ, Lee YS., Free PMC Article | 07/4/2020 |