| Growth Arrest-Specific 7 (GAS7) plays a critical role in phagocytic cup formation in macrophages. | Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7.
Hanawa-Suetsugu K, Itoh Y, Ab Fatah M, Nishimura T, Takemura K, Takeshita K, Kubota S, Miyazaki N, Wan Mohamad Noor WNI, Inaba T, Nguyen NTH, Hamada-Nakahara S, Oono-Yakura K, Tachikawa M, Iwasaki K, Kohda D, Yamamoto M, Kitao A, Shimada A, Suetsugu S., Free PMC Article | 01/25/2020 |
| Gas7-related M1 gene expression in alveolar macrophage was not dependent on NF-kappaB and STAT1 pathway | Growth arrest-specific protein 7 regulates the murine M1 alveolar macrophage polarization.
Xu Q, Liu X, Wang X, Hua Y, Wang X, Chen J, Li J, Wang Y, Stoeger T, Chen S, Huang N. | 07/7/2018 |
| These results demonstrate GAS7 as a susceptibility gene for schizophrenia. | Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis.
Zhang Z, Zheng F, You Y, Ma Y, Lu T, Yue W, Zhang D., Free PMC Article | 11/18/2017 |
| Forced expression of Gas7a or Gas7b isoform in mouse neuroblastoma Neuro2A cells, which express a defective Gas7 gene, rendered the cells proapoptotic and vulnerable to cisplatin-induced apoptosis. | Knockdown of growth-arrest-specific gene 7b (gas7b) using short-hairpin RNA desensitizes neuroblastoma cells to cisplatin: Implications for preventing apoptosis of neurons.
Hung FC, Chao CC. | 03/5/2011 |
| Gas7 works through its interaction with N-WASP during neuronal maturation/ differentiation | Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons.
You JJ, Lin-Chao S., Free PMC Article | 05/10/2010 |
| Gas7b has a role in microtubular maintenance | A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.
Akiyama H, Gotoh A, Shin RW, Koga T, Ohashi T, Sakamoto W, Harada A, Arai H, Sawa A, Uchida C, Uchida T., Free PMC Article | 01/21/2010 |
| These results suggest that Gas7 enhances microtubule polymerization by stabilizing sheet intermediates and is a useful tool for analyzing microtubule transformation. | Direct optical microscopic observation of the microtubule polymerization intermediate sheet structure in the presence of gas7.
Uchida T, Akiyama H, Sakamoto W, Koga T, Yan K, Uchida C, Hirose K, Itoh TJ. | 01/21/2010 |
| Hoxa7 and Hoxa9 contribute to hematopoietic progenitor homeostasis but are not necessary for MLL-GAS7-mediated leukemogenesis | Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.
So CW, Karsunky H, Wong P, Weissman IL, Cleary ML. | 01/21/2010 |
| Our data reveal that Gas7 might play a role in cellular migration and cell protection in the ES cells of mouse embryo. | Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice.
Moorthy PP, Kumar AA, Devaraj H. | 01/21/2010 |
| The ability of gas7 to potentiate neuronal differentiation makes it a potential therapeutic target to promote re-establishment of neuronal connections in the injured or diseased brain, such as following stroke. | The gas7 protein potentiates NGF-mediated differentiation of PC12 cells.
Lortie K, Huang D, Chakravarthy B, Comas T, Hou ST, Lin-Chao S, Morley P. | 01/21/2010 |
| Gas7 in PC12 cells leads to an expanded cell morphology and promotes neurite formation. These processes undergo elongation upon addition of nerve growth factor (NGF). | Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells.
Chao CC, Su LJ, Sun NK, Ju YT, Lih JC, Lin-Chao S. | 01/21/2010 |