| Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2. | Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2.
Li D, Liu Y, Li C, Zhou Z, Gao K, Bao H, Yang J, Xue G, Yin D, Zhao X, Shen K, Zhang L, Li J, Li C, Song J, Zhao L, Pei Y, Xuan L, Zhang Y, Lu Y, Zhang ZR, Yang B, Li Y, Pan Z. | 08/2/2024 |
| Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons. | Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons.
Tran A, Loganathan N, McIlwraith EK, Belsham DD. | 06/19/2021 |
| Involvement of Neuropeptide Galanin Receptors 2 and 3 in Learning, Memory and Anxiety in Aging Mice. | Involvement of Neuropeptide Galanin Receptors 2 and 3 in Learning, Memory and Anxiety in Aging Mice.
Locker F, Bieler L, Nowack LMF, Leitner J, Brunner SM, Zaunmair P, Kofler B, Couillard-Despres S., Free PMC Article | 05/29/2021 |
| molecular structures that confer ligand selectivity for galanin type II and III receptors | Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors.
Lee YN, Reyes-Alcaraz A, Yun S, Lee CS, Hwang JI, Seong JY., Free PMC Article | 06/27/2020 |
| These data demonstrate that Galanin (Gal) contributes not only to cholangiocyte proliferation but also to liver fibrogenesis via the coordinate activation of GalR1 in cholangiocytes and GalR2 in hepatic stellate cells (HSCs). | Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug Resistance Protein 2 Knockout Mice.
Petrescu AD, Grant S, Williams E, Frampton G, Parks N, Blaney H, Davies M, John R, Reinhart EH, McMillin M, DeMorrow S., Free PMC Article | 05/23/2020 |
| The data of this study support a specific role of GAL2-R but not of GAL3-R in mediating the anticonvulsive actions of endogenous galanin. | Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.
Drexel M, Sternberg’ F, Kofler B, Sperk G., Free PMC Article | 04/6/2019 |
| these results identify that GALR2 is a regulator of insulin resistance and activation of GALR2 represents a promising strategy against obesity-induced insulin resistance. | Activiated galanin receptor 2 attenuates insulin resistance in skeletal muscle of obese mice.
Fang P, Zhang L, Yu M, Sheng Z, Shi M, Zhu Y, Zhang Z, Bo P. | 08/4/2018 |
| In chronic restraint stress, the expression of GalR2 is increased in the nucleus accumbens following antidepressant administration. | The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress.
Zhao X, Seese RR, Yun K, Peng T, Wang Z. | 03/1/2014 |
| Three age groups of the Galr2 overexpressing mice demonstrated decreased levels of immobility in the forced swim test, indicative of antidepressive-like behavior and/or increased stress resistance. | Galanin receptor 2 overexpressing mice display an antidepressive-like phenotype: possible involvement of the subiculum.
Le Maître TW, Xia S, Le Maitre E, Dun XP, Lu J, Theodorsson E, Ogren SO, Hökfelt T, Xu ZQ. | 07/7/2012 |
| High level of endogenous galanin in injured primary afferents activates peripheral GalR2, which leads to an increase in C-fibre mechanical activation thresholds and a marked reduction in evoked and ongoing nociceptive responses. | Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia.
Hulse RP, Wynick D, Donaldson LF., Free PMC Article | 09/17/2011 |
| The result indicate that galanin and its receptors (GalR1 and GalR2) might regulate neurite extension in differentiating neural stem cells and even participate in the development of the nervous system. | [Expression of galanin and galanin receptors in neurogenesis regions of adult mouse brain and effect of galanin on the neural stem cell's differentiation].
Ma J, Shan L, Yu LL, Yuan CG. | 01/21/2010 |
| The present findings are consistent with a predicted antidepressant-like effect of GalR2 signaling, suggesting that GalR2 might be a valid drug target for depressive disorders. | Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests.
Lu X, Ross B, Sanchez-Alavez M, Zorrilla EP, Bartfai T., Free PMC Article | 01/21/2010 |
| Galr2 receptors stimulate vagal afferent mechanosensitivity in the gastro-esophageal afferent preparation. | Involvement of galanin receptors 1 and 2 in the modulation of mouse vagal afferent mechanosensitivity.
Page AJ, Slattery JA, Brierley SM, Jacoby AS, Blackshaw LA., Free PMC Article | 01/21/2010 |
| To gain insight into the possible physiological significance of GALR2, phenotypic analysis of mice deficient in GALR2 was determined. | Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2).
Gottsch ML, Zeng H, Hohmann JG, Weinshenker D, Clifton DK, Steiner RA., Free PMC Article | 01/21/2010 |
| These findings imply that the rise in endogenous galanin observed either after brain injury or in various disease states is an adaptive response that reduces apoptosis by the activation of GalR2, and hence Akt and ERK. | Activation of the galanin receptor 2 (GalR2) protects the hippocampus from neuronal damage.
Elliott-Hunt CR, Pope RJ, Vanderplank P, Wynick D., Free PMC Article | 01/21/2010 |
| lack of GalR2 activation in galanin knockout and GalR2-MUT animals is responsible for the observed developmental deficits in the dorsal root ganglia | Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour.
Hobson SA, Holmes FE, Kerr NC, Pope RJ, Wynick D., Free PMC Article | 01/21/2010 |
| the discovery of an anxiogenic phenotype specific to the elevated plus-maze highlights the potential therapeutic efficacy of targeting GalR2 receptors in treating anxiety disorders | Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze.
Bailey KR, Pavlova MN, Rohde AD, Hohmann JG, Crawley JN., Free PMC Article | 01/21/2010 |