| B4galnt2 displays an interesting spatial allelic distribution in Western Europe, likely due to the recent action of natural selection. | Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice.
Vallier M, Abou Chakra M, Hindersin L, Linnenbrink M, Traulsen A, Baines JF., Free PMC Article | 12/23/2017 |
| Overexpression of Galgt2 failed to inhibit skeletal muscle pathology in dystroglycan-deficient muscles | Deletion of Galgt2 (B4Galnt2) reduces muscle growth in response to acute injury and increases muscle inflammation and pathology in dystrophin-deficient mice.
Xu R, Singhal N, Serinagaoglu Y, Chandrasekharan K, Joshi M, Bauer JA, Janssen PM, Martin PT., Free PMC Article | 05/7/2016 |
| These data support a critical role for B4galnt2 in gastrointestinal infections | Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection.
Rausch P, Steck N, Suwandi A, Seidel JA, Künzel S, Bhullar K, Basic M, Bleich A, Johnsen JM, Vallance BA, Baines JF, Grassl GA., Free PMC Article | 04/9/2016 |
| Galgt2 is required for postsynaptic expression of the CT carbohydrate at the neuromuscular junction. | Distinct contributions of Galgt1 and Galgt2 to carbohydrate expression and function at the mouse neuromuscular junction.
Singhal N, Xu R, Martin PT., Free PMC Article | 04/20/2013 |
| We describe changes that result from overexpression of Galgt2, a normally synaptic muscle glycosyltransferase that can modify alpha dystroglycan and inhibit the development of muscular dystrophy when it is overexpressed. | Comparative proteomic profiling of dystroglycan-associated proteins in wild type, mdx, and Galgt2 transgenic mouse skeletal muscle.
Yoon JH, Johnson E, Xu R, Martin LT, Martin PT, Montanaro F., Free PMC Article | 03/30/2013 |
| Study describes detailed characterization of mouse gastrointestinal bacterial communities in 7 distinct locations from the duodenum to the colon and provide evidence for a significant effect of B4galnt2 expression on intestinal bacterial populations. | Expression of the blood-group-related glycosyltransferase B4galnt2 influences the intestinal microbiota in mice.
Staubach F, Künzel S, Baines AC, Yee A, McGee BM, Bäckhed F, Baines JF, Johnsen JM., Free PMC Article | 03/2/2013 |
| Data suggest that B4GALNT2 and Sd(a) antigen are essential for embryo implantation. | Localization of B4GALNT2 and its role in mouse embryo attachment.
Li PT, Liao CJ, Yu LC, Wu WG, Chu ST. | 06/30/2012 |
| Expression of B4galnt2 in pregnant mice is regulated by progesterone. The naturally occurring up-regulation of B4galnt2 during pregnancy contributes to normal embryo implantation. | Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice.
Li PT, Liao CJ, Wu WG, Yu LC, Chu ST. | 07/30/2011 |
| Galgt2 has therapeutic effects in three distinct forms of muscular dystrophy | Overexpression of Galgt2 reduces dystrophic pathology in the skeletal muscles of alpha sarcoglycan-deficient mice.
Xu R, DeVries S, Camboni M, Martin PT., Free PMC Article | 01/21/2010 |
| low VWF levels may represent a fitness cost that is offset by a yet unknown benefit of the B4galnt2 tissue-specific switch. | Selection on cis-regulatory variation at B4galnt2 and its influence on von Willebrand factor in house mice.
Johnsen JM, Teschke M, Pavlidis P, McGee BM, Tautz D, Ginsburg D, Baines JF., Free PMC Article | 01/21/2010 |
| Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice. | Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice.
Martin PT, Xu R, Rodino-Klapac LR, Oglesbay E, Camboni M, Montgomery CL, Shontz K, Chicoine LG, Clark KR, Sahenk Z, Mendell JR, Janssen PM., Free PMC Article | 01/21/2010 |
| These experiments demonstrate that Galgt2 can control growth by modulating the expression of myostatin and myostatin inhibitors during particular periods of muscle development. | Embryonic overexpression of Galgt2 inhibits skeletal muscle growth via activation of myostatin signaling.
Chandraskeharan K, Martin PT. | 01/21/2010 |
| we show that overexpression of the cytotoxic T cell (CT) GalNAc transferase (Galgt2) is effective in inhibiting the development of muscle pathology in the dy(W) mouse model of MDC1A | Overexpression of the cytotoxic T cell (CT) carbohydrate inhibits muscular dystrophy in the dyW mouse model of congenital muscular dystrophy 1A.
Xu R, Chandrasekharan K, Yoon JH, Camboni M, Martin PT., Free PMC Article | 01/21/2010 |