| These data suggest that pubertal synaptic pruning requires alpha4betadelta GABA-A receptors. | Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines.
Afroz S, Parato J, Shen H, Smith SS., Free PMC Article | 11/4/2017 |
| Gabra4 KO CD4(+) cells produced increased cytokines. | GABA(A) receptor α(4)-subunit knockout enhances lung inflammation and airway reactivity in a murine asthma model.
Yocum GT, Turner DL, Danielsson J, Barajas MB, Zhang Y, Xu D, Harrison NL, Homanics GE, Farber DL, Emala CW., Free PMC Article | 09/2/2017 |
| Rindings suggest that knock-out of the GABAR alpha4 subunit restores synaptic plasticity and spatial learning at puberty and is consistent with the concept that the dendritic alpha4betadelta GABARs which emerge at puberty selectively impair central nervous system plasticity. | Role of α4-containing GABA(A) receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period.
Shen H, Sabaliauskas N, Yang L, Aoki C, Smith SS., Free PMC Article | 08/5/2017 |
| This study addressed the effects of AW on changes in the expression of Gabra4 and related genes that encode other subunits of GABAARs | Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons.
Bekdash RA, Harrison NL., Free PMC Article | 06/28/2016 |
| The alpha4 subunit-containing GABA A-receptors are required for the low dose, locomotor stimulatory effect of anesthetics. | GABAA-R α4 subunits are required for the low dose locomotor stimulatory effect of alphaxalone, but not for several other behavioral responses to alphaxalone, etomidate or propofol.
Iyer SV, Chandra D, Homanics GE., Free PMC Article | 01/31/2015 |
| GABAA receptors in the mediodorsal thalamic nucleus (MD) modulate fear extinction. | Extrasynaptic GABAA receptors in mediodorsal thalamic nucleus modulate fear extinction learning.
Paydar A, Lee B, Gangadharan G, Lee S, Hwang EM, Shin HS., Free PMC Article | 10/4/2014 |
| Increase in GABRA4 activity promotes hippocampal neurogenesis via nuclear factor of activated T cell (NFATc)4. | Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4.
Quadrato G, Elnaggar MY, Duman C, Sabino A, Forsberg K, Di Giovanni S., Free PMC Article | 08/16/2014 |
| This study demonistrated that alpha4-GABAARs contribute to nRT burst-mediated inhibition and that activity-dependent recruitment of eGABAARs dynamically influences the ventrobasal neuron tonic conductance during nRT tonic spike trains. | Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus.
Herd MB, Brown AR, Lambert JJ, Belelli D., Free PMC Article | 12/7/2013 |
| alpha4 subunit expression strongly influences the pubertal increase of delta subunits at the plasma membrane, and that genetic deletion of alpha4 serves as a functional knock-down of delta-containing GABARs. | Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty.
Sabaliauskas N, Shen H, Homanics GE, Smith SS, Aoki C., Free PMC Article | 09/15/2012 |
| Data suggest that the availability of distinct GABA(A) R subtypes (Gabra2, -4, and Gabrd) provides a molecular mechanism endowing spatiotemporal specificity to GABAergic control of neuronal maturation in adult brain. | Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis.
Duveau V, Laustela S, Barth L, Gianolini F, Vogt KE, Keist R, Chandra D, Homanics GE, Rudolph U, Fritschy JM., Free PMC Article | 01/28/2012 |
| findings show that emergence of alpha4betadelta GABARs at puberty impairs learning, an effect that can be reversed by a stress steroid | A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in mice.
Shen H, Sabaliauskas N, Sherpa A, Fenton AA, Stelzer A, Aoki C, Smith SS., Free PMC Article | 04/12/2010 |
| Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. | Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane.
Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI 2nd, Fanselow MS, Homanics GE, Sonner JM., Free PMC Article | 01/21/2010 |
| alpha-4 subunit of the GABAA receptor is transcriptionally regulated | Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor.
Ma L, Song L, Radoi GE, Harrison NL. | 01/21/2010 |