| Small Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid. | Small Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid.
Huang L, Liao Q, Pan T, Sun Y, Aluo Z, Xiao L, Yu J, Liu S, Xiao Y, Yang Y, Li Y, Zhou L., Free PMC Article | 10/29/2022 |
| Synergistic regulation of hepatic Fsp27b expression by HNF4alpha and CREBH. | Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH.
Kasano-Camones CI, Takizawa M, Iwasaki W, Sasaki S, Hamada M, Morimoto A, Sakaguchi M, Gonzalez FJ, Inoue Y., Free PMC Article | 02/27/2021 |
| Fat-specific protein 27b is regulated by hepatic peroxisome proliferator-activated receptor gamma in hepatic steatosis. | Fat-specific protein 27b is regulated by hepatic peroxisome proliferator-activated receptor γ in hepatic steatosis.
Aibara D, Matsuo K, Yamano S, Matsusue K. | 11/21/2020 |
| Eicosapentaenoic acid-enriched phospholipids suppressed lipid accumulation by specific inhibition of lipid droplet-associated protein FSP27 in mice. | Eicosapentaenoic acid-enriched phospholipids suppressed lipid accumulation by specific inhibition of lipid droplet-associated protein FSP27 in mice.
Zhang L, Ding L, Shi H, Wang C, Xue C, Zhang T, Wang Y. | 11/21/2020 |
| When Pgc1a-deficient mice were used, the sex differences in Cidec/Fsp27beta expression disappeared | Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet.
Herrera-Marcos LV, Sancho-Knapik S, Gabás-Rivera C, Barranquero C, Gascón S, Romanos E, Martínez-Beamonte R, Navarro MA, Surra JC, Arnal C, García-de-Jalón JA, Rodríguez-Yoldi MJ, Tena-Sempere M, Sánchez-Ramos C, Monsalve M, Osada J. | 05/9/2020 |
| Growth hormone-induced lipolysis is secondary to its reduction in the expression of FSP27. | Growth hormone controls lipolysis by regulation of FSP27 expression.
Sharma R, Luong Q, Sharma VM, Harberson M, Harper B, Colborn A, Berryman DE, Jessen N, Jørgensen JOL, Kopchick JJ, Puri V, Lee KY., Free PMC Article | 09/14/2019 |
| LXRalpha positively regulates Fsp27a and Fsp27b expression. | Fat-specific protein 27 is a novel target gene of liver X receptor α.
Aibara D, Matsusue K, Takiguchi S, Gonzalez FJ, Yamano S., Free PMC Article | 05/11/2019 |
| a CIDEC domain that regulates LD fusion activity | Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids.
Wang J, Yan C, Xu C, Chua BT, Li P, Chen FJ., Free PMC Article | 04/13/2019 |
| the role of gp78 and cidec in hepatic steatosis, were investigated. | Role of glycoprotein 78 and cidec in hepatic steatosis.
Li J, Liu G, Zhang F, Zhang Z, Xu Y, Li Q., Free PMC Article | 05/12/2018 |
| The current study demonstrated that insulin represses fasting-induced Fsp27 expression in the liver. The Fsp27 decreased by insulin is likely to cause the lower fat accumulation in liver. | Insulin Represses Fasting-Induced Expression of Hepatic Fat-Specific Protein 27.
Matsuo K, Matsusue K, Aibara D, Takiguchi S, Gonzalez FJ, Yamano S., Free PMC Article | 03/10/2018 |
| Fatty acids prevent CIDEC deacetylation by promoting the dissociation of CIDEC from HDAC6, resultin in increased association of CIDEC with PCAF on the endoplasmic reticulum. | HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage.
Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P., Free PMC Article | 09/16/2017 |
| We show that partial silencing Fsp27 in either model results in the robust decrease in visceral fat, improved insulin sensitivity and whole-body glycemic control, and tissue-specific changes in transcripts controlling lipid oxidation and synthesis | Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance.
Langhi C, Arias N, Rajamoorthi A, Basta J, Lee RG, Baldán Á., Free PMC Article | 08/26/2017 |
| results suggest that FSP27beta negatively regulates CideA-promoted enlargement of lipid droplet size in brown adipocytes. | Cell death-inducing DNA fragmentation factor A-like effector A and fat-specific protein 27β coordinately control lipid droplet size in brown adipocytes.
Nishimoto Y, Nakajima S, Tateya S, Saito M, Ogawa W, Tamori Y., Free PMC Article | 07/8/2017 |
| Lipid droplet (LD) expansion depends on the FSP27 carboxy-terminal domain (amino acids 131-239). The negative charge of acidic residues D215, E218, E219 and E220 in the polar carboxy-terminal region (amino acids 202-239) is essential for LD enlargement. | Negatively-charged residues in the polar carboxy-terminal region in FSP27 are indispensable for expanding lipid droplets.
Tamori Y, Tateya S, Ijuin T, Nishimoto Y, Nakajima S, Ogawa W. | 08/13/2016 |
| Data (including data from studies in knockout mice) suggest Cideb promotes lipid storage as droplets in hepatocytes under normal diet conditions; Cidea/Cidec promote fusion of lipid droplets leading to liver steatosis in fasting (16h) and obese mice. | Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes.
Xu W, Wu L, Yu M, Chen FJ, Arshad M, Xia X, Ren H, Yu J, Xu L, Xu D, Li JZ, Li P, Zhou L., Free PMC Article | 08/6/2016 |
| Cidea is highly associated with adiposity and insulin resistance, whereas Cidec is related to insulin sensitivity | Effects of a High Fat Diet and Voluntary Wheel Running Exercise on Cidea and Cidec Expression in Liver and Adipose Tissue of Mice.
Reynolds TH 4th, Banerjee S, Sharma VM, Donohue J, Couldwell S, Sosinsky A, Frulla A, Robinson A, Puri V., Free PMC Article | 04/23/2016 |
| Hepatic expression of FSP27/CIDEC is highly up-regulated in mice following chronic-plus-binge ethanol feeding and this up-regulation contributes to alcohol-induced liver damage. | Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.
Xu MJ, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, Odena G, Lu J, Tanaka N, Matsusue K, Matsubara T, Mukhopadhyay P, Kimura S, Pacher P, Gonzalez FJ, Bataller R, Gao B., Free PMC Article | 01/2/2016 |
| Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice. | Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice.
Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F, Yang H, Choi CS, Savage DB, Li P., Free PMC Article | 12/12/2015 |
| CREBH-Fsp27beta axis is important for regulating lipid droplet dynamics and triglyceride storage in the liver | Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis.
Xu X, Park JG, So JS, Lee AH., Free PMC Article | 04/25/2015 |
| Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice. | Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice.
Tanaka N, Takahashi S, Matsubara T, Jiang C, Sakamoto W, Chanturiya T, Teng R, Gavrilova O, Gonzalez FJ., Free PMC Article | 04/18/2015 |
| Promotion of FSP27 degradation may be an important factor responsible for the beneficial effect of AMPK activators on energy metabolism | Regulation of FSP27 protein stability by AMPK and HSC70.
Zhang X, Heckmann BL, Xie X, Saarinen AM, Liu J., Free PMC Article | 02/28/2015 |
| results demonstrate a crucial role for FSP27-ATGL interactions in regulating lipolysis, triglyceride accumulation, and insulin signaling in human adipocytes | Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes.
Grahn THM, Kaur R, Yin J, Schweiger M, Sharma VM, Lee MJ, Ido Y, Smas CM, Zechner R, Lass A, Puri V., Free PMC Article | 06/28/2014 |
| FSP27 mRNA expression in the liver depends on the etiology of fatty liver. | Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver.
Aibara D, Matsusue K, Matsuo K, Takiguchi S, Gonzalez FJ, Yamano S., Free PMC Article | 06/21/2014 |
| Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate. | Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate.
Vilà-Brau A, De Sousa-Coelho AL, Gonçalves JF, Haro D, Marrero PF., Free PMC Article | 09/7/2013 |
| Perilipin1 (Plin1), another adipocyte-specific lipid droplet-associated protein, is an Fsp27 activator. | Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.
Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu JW, Yang H, Yang M, Li P., Free PMC Article | 06/22/2013 |