| Crym-positive striatal astrocytes gate perseverative behaviour. | Crym-positive striatal astrocytes gate perseverative behaviour.
Ollivier M, Soto JS, Linker KE, Moye SL, Jami-Alahmadi Y, Jones AE, Divakaruni AS, Kawaguchi R, Wohlschlegel JA, Khakh BS., Free PMC Article | 03/23/2024 |
| Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators. | Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators.
Sakkaki E, Jafari B, Gharesouran J, Rezazadeh M. | 02/26/2024 |
| Thyroid and androgen receptor signaling are antagonized by mu-Crystallin in prostate cancer. | Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer.
Aksoy O, Pencik J, Hartenbach M, Moazzami AA, Schlederer M, Balber T, Varady A, Philippe C, Baltzer PA, Mazumder B, Whitchurch JB, Roberts CJ, Haitel A, Herac M, Susani M, Mitterhauser M, Marculescu R, Stangl-Kremser J, Hassler MR, Kramer G, Shariat SF, Turner SD, Tichy B, Oppelt J, Pospisilova S, Hartenbach S, Tangermann S, Egger G, Neubauer HA, Moriggl R, Culig Z, Greiner G, Hoermann G, Hacker M, Heery DM, Merkel O, Kenner L., Free PMC Article | 06/26/2021 |
| Results suggest that mu-crystallin may play roles in development of cortical and hippocampal pyramidal cells in the early postnatal period, and in the later period, performs cell-specific functions in selected neuronal populations. | Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis.
Hommyo R, Suzuki SO, Abolhassani N, Hamasaki H, Shijo M, Maeda N, Honda H, Nakabeppu Y, Iwaki T. | 10/20/2018 |
| These findings confirm that, mechanistically, ketimine reductase/CRYM acts as a classical imine reductase and may explain the finding of bound pyruvate in the crystallized protein. | Ketimine reductase/CRYM catalyzes reductive alkylamination of α-keto acids, confirming its function as an imine reductase.
Hallen A, Cooper AJ, Smith JR, Jamie JF, Karuso P. | 08/13/2016 |
| ketimine reductase is a key enzyme in the pipecolate pathway, which is the main lysine degradation pathway in the brain | Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions.
Hallen A, Cooper AJ, Jamie JF, Karuso P. | 03/12/2016 |
| The expression of mu-crystallin was regulated through the AP-1 site in the promoter. | Possible roles of the AP-1 site in the cytosolic T3 binding protein promoter and insights into its physiological significance.
Suzuki S, Nishio SI, Ishii H, Sekido T, Takeshige K, Ohkubo Y, Hiwatashi D, Takeda T, Komatsu M. | 01/25/2014 |
| The purified human mu-crystallin was confirmed to have ketimine reductase activity with a maximum specific activity similar to that of native ovine ketimine reductase | Mammalian forebrain ketimine reductase identified as μ-crystallin; potential regulation by thyroid hormones.
Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD, Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD, Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD. | 09/17/2011 |
| Its ketimine reductase activity is strongly inhibited by thyroid hormones. | Mammalian forebrain ketimine reductase identified as μ-crystallin; potential regulation by thyroid hormones.
Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD, Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD, Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD. | 03/22/2011 |
| Its enzyme function has been determined as a ketimine reductase in mammalian brain. | Mammalian forebrain ketimine reductase identified as μ-crystallin; potential regulation by thyroid hormones.
Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD, Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD, Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD. | 03/22/2011 |
| This protein has been found differentially expressed in thalami from patients with schizophrenia. | Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, Falkai P, Schmitt A, Turck CW. | 07/13/2010 |
| This is the first report linking hyperglycemia with thyroid hormone binding protein CRYM and suggests that the role of CRYM in diabetic complications should be further investigated. | Hyperglycemia induces elevated expression of thyroid hormone binding protein in vivo in kidney and heart and in vitro in mesangial cells.
Al-Kafaji G, Malik AN. | 03/8/2010 |
| CRYM is a novel androgen-regulated gene whose expression is elevated in prostate cancer but down-regulated in castration therapy-resistant tumors. | Identification of mu-crystallin as an androgen-regulated gene in human prostate cancer.
Malinowska K, Cavarretta IT, Susani M, Wrulich OA, Uberall F, Kenner L, Culig Z. | 01/21/2010 |
| Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW. | 01/28/2009 |
| This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Maccarrone G, Hunyadi-Gulyás E, Eberlin MN, Souza GH, Marangoni S, Novello JC, Turck CW, Dias-Neto E. | 12/29/2008 |
| Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues | Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues.
Abe S, Katagiri T, Saito-Hisaminato A, Usami S, Inoue Y, Tsunoda T, Nakamura Y., Free PMC Article | 01/21/2010 |
| up-regulation of mu-crystallin may play a specific and important role in pathogenesis of facioscapulohumeral muscular dystrophy | Abnormal expression of mu-crystallin in facioscapulohumeral muscular dystrophy.
Reed PW, Corse AM, Porter NC, Flanigan KM, Bloch RJ. | 01/21/2010 |