| FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes. | FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes.
Pettinato M, Dulja A, Colucci S, Furiosi V, Fette F, Steinbicker AU, Muckenthaler MU, Nai A, Pagani A, Silvestri L. | 07/19/2023 |
| FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts. | FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts.
Battaglino RA, Jha P, Sultana F, Liu W, Morse LR., Free PMC Article | 09/5/2020 |
| cardiomyocyte-restricted overexpression of FKBP12 reduces the atrial Nav1.5 expression level and mean peak INa, which is associated with increased peak L-type Ca(2+) current and interstitial fibrosis in atria. The combined electrophysiological and structural changes facilitated the development of local conduction block and altered action potential duration and spontaneous AF. | Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12.
Pan Z, Ai T, Chang PC, Liu Y, Liu J, Maruyama M, Homsi M, Fishbein MC, Rubart M, Lin SF, Xiao D, Chen H, Chen PS, Shou W, Li BY., Free PMC Article | 12/28/2019 |
| Acute tacrolimus treatment transiently increases hepcidin in wild-type mice. FKBP12 preferentially targets the BMP receptor ALK2. ALK2 mutants defective in binding FKBP12 increase hepcidin expression in a ligand-independent manner, through BMP-SMAD signaling. | The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes.
Colucci S, Pagani A, Pettinato M, Artuso I, Nai A, Camaschella C, Silvestri L., Free PMC Article | 11/25/2017 |
| FKBP51 is a central mediator of chronic pain. | The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling.
Maiarù M, Tochiki KK, Cox MB, Annan LV, Bell CG, Feng X, Hausch F, Géranton SM., Free PMC Article | 11/19/2016 |
| We demonstrate that FKBP12 and its ligands impact multiple aspects of muscle function. | Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.
Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL., Free PMC Article | 02/21/2015 |
| Fkbp1a-mediated regulation of Notch1 plays an important role in intercellular communication between endocardium and myocardium. | Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity.
Chen H, Zhang W, Sun X, Yoshimoto M, Chen Z, Zhu W, Liu J, Shen Y, Yong W, Li D, Zhang J, Lin Y, Li B, VanDusen NJ, Snider P, Schwartz RJ, Conway SJ, Field LJ, Yoder MC, Firulli AB, Carlesso N, Towbin JA, Shou W., Free PMC Article | 06/1/2013 |
| FKBP12 is critically important in regulating trans-sarcolemmal ionic currents, predominately the voltage-gated Na+ current, I Na | The role of FK506-binding proteins 12 and 12.6 in regulating cardiac function.
Li BY, Chen H, Maruyama M, Zhang W, Zhang J, Pan ZW, Rubart M, Chen PS, Shou W., Free PMC Article | 04/27/2013 |
| the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 and FKBP12.6, and intracellular calcium dynamics was investigated. | Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics.
Åström-Olsson K, Li L, Olofsson CS, Borén J, Öhlin H, Grip L. | 09/8/2012 |
| Data show that deletion of FKBP12 increased transforming growth factor-beta receptor activation and SMAD2/3 signaling. | FK506 binding protein 12 deficiency in endothelial and hematopoietic cells decreases regulatory T cells and causes hypertension.
Chiasson VL, Talreja D, Young KJ, Chatterjee P, Banes-Berceli AK, Mitchell BM., Free PMC Article | 07/23/2011 |
| FKBP12 is a critical regulator of I(Na) and is important for cardiac arrhythmogenic physiology | FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice.
Maruyama M, Li BY, Chen H, Xu X, Song LS, Guatimosim S, Zhu W, Yong W, Zhang W, Bu G, Lin SF, Fishbein MC, Lederer WJ, Schild JH, Field LJ, Rubart M, Chen PS, Shou W., Free PMC Article | 07/2/2011 |
| tacrolimus alters intracellular calcium and eNOS by binding to FKBP | Tacrolimus reduces nitric oxide synthase function by binding to FKBP rather than by its calcineurin effect.
Cook LG, Chiasson VL, Long C, Wu GY, Mitchell BM., Free PMC Article | 01/21/2010 |
| The results of this study indicate that FKBP12 plays a critical role in the regulation of mTOR-Raptor interactions, LTP, memory, and perseverative behaviors. | Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior.
Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E., Free PMC Article | 01/21/2010 |
| FKBP12 deficiency results in less initial strength deficits and enhanced recovery from single (especially females) and repeated bouts of injury than wild type mice | FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury.
Corona BT, Rouviere C, Hamilton SL, Ingalls CP., Free PMC Article | 01/21/2010 |
| These data strongly suggests that FKBP-12 is altered in an experimental model of PD. | Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins.
Nilsson A, Sköld K, Sjögren B, Svensson M, Pierson J, Zhang X, Caprioli RM, Buijs J, Persson B, Svenningsson P, Andrén PE. | 01/21/2010 |
| analysis of FK506-rapamycin binding (FRB) protein mutant rescue with chemical ligands | Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands.
Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR, Gestwicki JE. | 01/21/2010 |
| used systemic gene transfer in tumor-bearing mice to identify novel antiinvasive and antimetastatic functions for Fkbp8, and subsequently for Fkbp1a | Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family.
Fong S, Mounkes L, Liu Y, Maibaum M, Alonzo E, Desprez PY, Thor AD, Kashani-Sabet M, Debs RJ., Free PMC Article | 01/21/2010 |
| FKBP12 deficiency alters both orthograde and retrograde coupling between the L-type Ca2+ channel and RyR1 and the consequences of these changes depend on muscle type and activity | Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency.
Tang W, Ingalls CP, Durham WJ, Snider J, Reid MB, Wu G, Matzuk MM, Hamilton SL. | 01/21/2010 |
| manipulating the stoichiometry between calstabin2 and ryanodine receptor 2 can restore normal cardiac function in vivo | Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice.
Huang F, Shan J, Reiken S, Wehrens XH, Marks AR., Free PMC Article | 01/21/2010 |
| a trimeric-interaction among calcineurin, FKBP12, and RyR is important for the regulation of the RyR channel activity and may play an important role in the Ca(2+) signaling of muscle contraction and relaxation | Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle.
Shin DW, Pan Z, Bandyopadhyay A, Bhat MB, Kim DH, Ma J., Free PMC Article | 01/21/2010 |
| FKBP12 binding to RyR1 enhances the gain of skeletal muscle excitation-contraction coupling | FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes.
Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT. | 01/21/2010 |