| FGFR3 drives Abeta-induced tau uptake. | FGFR3 drives Aβ-induced tau uptake.
Kim DK, Suh K, Park J, Lee SE, Han J, Chang S, Kim Y, Mook-Jung I., Free PMC Article | 09/12/2024 |
| DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis. | DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis.
Zhang Z, Guo Q, Zhao Z, Nie M, Shi Q, Li E, Liu K, Yu H, Rao L, Li M. | 07/24/2023 |
| Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice. | Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice.
Loisay L, Komla-Ebri D, Morice A, Heuzé Y, Viaut C, de La Seiglière A, Kaci N, Chan D, Lamouroux A, Baujat G, Bassett JHD, Williams GR, Legeai-Mallet L., Free PMC Article | 06/23/2023 |
| Downregulated FGFR3 Expression Inhibits In Vitro Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells of Mice with TBXT Gene Mutation. | Downregulated FGFR3 Expression Inhibits In Vitro Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells of Mice with TBXT Gene Mutation.
Su H, Yang G, Yang HX, Liu MN, Li XD, Chen L, Li Y, Wang DQ, Ma T, Song YL, Li HJ, Du CG, Li XH, Cao GF. | 04/4/2023 |
| Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice. | Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice.
Kato D, Matsushita M, Takegami Y, Mishima K, Kamiya N, Osawa Y, Imagama S, Kitoh H. | 11/5/2022 |
| FGFR3 overactivation in the brain is responsible for memory impairments in Crouzon syndrome mouse model. | FGFR3 overactivation in the brain is responsible for memory impairments in Crouzon syndrome mouse model.
Cornille M, Moriceau S, Khonsari RH, Heuzé Y, Loisay L, Boitez V, Morice A, Arnaud E, Collet C, Bensidhoum M, Kaci N, Boddaert N, Paternoster G, Rauschendorfer T, Werner S, Mansour SL, Di Rocco F, Oury F, Legeai-Mallet L., Free PMC Article | 05/7/2022 |
| An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton. | An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton.
Biosse Duplan M, Dambroise E, Estibals V, Veziers J, Guicheux J, Legeai-Mallet L., Free PMC Article | 02/5/2022 |
| Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway. | Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway.
Zhang D, Huang J, Sun X, Chen H, Huang S, Yang J, Du X, Tan Q, Luo F, Zhang R, Zhou S, Jiang W, Ni Z, Wang Z, Jin M, Xu M, Li F, Chen L, Liu M, Su N, Luo X, Yin L, Zhu Y, Feng JQ, Chen D, Qi H, Chen L, Xie Y., Free PMC Article | 08/7/2021 |
| Loss of FGFR3 Accelerates Bone Marrow Suppression-Induced Hematopoietic Stem and Progenitor Cell Expansion by Activating FGFR1-ELK1-Cyclin D1 Signaling. | Loss of FGFR3 Accelerates Bone Marrow Suppression-Induced Hematopoietic Stem and Progenitor Cell Expansion by Activating FGFR1-ELK1-Cyclin D1 Signaling.
Ran Q, Guo C, Sun C, Liu Q, He H, Zhao W, Zhang J, Xiao Y. | 07/24/2021 |
| FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair. | FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair.
Julien A, Perrin S, Duchamp de Lageneste O, Carvalho C, Bensidhoum M, Legeai-Mallet L, Colnot C., Free PMC Article | 07/3/2021 |
| Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes. | Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.
Meyer M, Ben-Yehuda Greenwald M, Rauschendorfer T, Sänger C, Jukic M, Iizuka H, Kubo F, Chen L, Ornitz DM, Werner S., Free PMC Article | 04/24/2021 |
| Expression of fibroblast growth factor receptor1, -2c, and -3c transcripts in mouse molars after tooth eruption. | Expression of fibroblast growth factor receptor1, -2c, and -3c transcripts in mouse molars after tooth eruption.
Kano T, Morita T, Sumida K, Yumoto H, Baba O. | 04/17/2021 |
| LncRNA KCNQ1OT1 accelerates fracture healing via modulating miR-701-3p/FGFR3 axis. | LncRNA KCNQ1OT1 accelerates fracture healing via modulating miR-701-3p/FGFR3 axis.
Chen L, Xiong Y, Yan C, Zhou W, Endo Y, Xue H, Hu Y, Hu L, Leng X, Liu J, Lin Z, Mi B, Liu G. | 01/23/2021 |
| Enhanced FGFR3 activity in postmitotic principal neurons during brain development results in cortical dysplasia and axonal tract abnormality. | Enhanced FGFR3 activity in postmitotic principal neurons during brain development results in cortical dysplasia and axonal tract abnormality.
Huang JY, Krebs BB, Miskus ML, Russell ML, Duffy EP, Graf JM, Lu HC., Free PMC Article | 01/16/2021 |
| FGFR3 is a key factor for the regulation of macrophage recruitment in synovium. FGFR3 deficiency in macrophages contribute to the development of synovitis and result in multiple joints destruction in mice. FGFR3 inhibits CXCR7 expression and CXCL12-dependent chemotaxis of macrophages through regulating the NF-kappaB pathways. | FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice.
Kuang L, Wu J, Su N, Qi H, Chen H, Zhou S, Xiong Y, Du X, Tan Q, Yang J, Jin M, Luo F, Ouyang J, Zhang B, Wang Z, Jiang W, Chen L, Chen S, Wang Z, Liu P, Yin L, Guo F, Deng C, Chen D, Liu C, Xie Y, Ni Z, Chen L. | 04/25/2020 |
| Transient Redirection of SVZ Stem Cells to Oligodendrogenesis by FGFR3 Activation Promotes Remyelination. | Transient Redirection of SVZ Stem Cells to Oligodendrogenesis by FGFR3 Activation Promotes Remyelination.
Kang W, Nguyen KCQ, Hébert JM., Free PMC Article | 04/18/2020 |
| The patient-specific growth plate cartilage xenograft model for FGFR3 skeletal dysplasia indicated recapitulation of pathology and effectiveness of a FGFR inhibitor for treatment and warrants more study for its usefulness to study disease pathology and drug testing. | Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia.
Kimura T, Ozaki T, Fujita K, Yamashita A, Morioka M, Ozono K, Tsumaki N. | 11/9/2019 |
| Study in Runx2-/- mice revealed that number of osteoblast progenitors and their proliferation were dependent on the gene dosage of Runx2 in background. The expression of Fgfr2 and Fgfr3 was severely reduced in Runx2-/- calvariae. These results indicate that Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation, at least partly, by regulating Fgfr2 and Fgfr3 expression. | Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3.
Kawane T, Qin X, Jiang Q, Miyazaki T, Komori H, Yoshida CA, Matsuura-Kawata VKDS, Sakane C, Matsuo Y, Nagai K, Maeno T, Date Y, Nishimura R, Komori T., Free PMC Article | 11/2/2019 |
| FGFR3 may play a central role in lymphatic endothelial cell proliferation, migration, tubule formation, and lymphangiogenesis. | Modulation of Fibroblast Growth Factor Expression in Lymphedema.
Rockson SG. | 08/3/2019 |
| These findings indicate that a deficiency of SAM3, a novel brain-specific chemokine-like molecule, may lead to the pathogenesis of ASDs and suggest the possibility that SAM3, a soluble factor, could be a novel therapeutic target for ASD treatment. | Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice.
Kim S, Lee B, Choi JH, Kim JH, Kim CH, Shin HS., Free PMC Article | 07/13/2019 |
| Variations in Fgf3 signaling activity contribute to the severity of the osteochondroma phenotype by affecting both, osteochondroma size and number, in distinct manners. | Signaling systems affecting the severity of multiple osteochondromas.
Piombo V, Jochmann K, Hoffmann D, Wuelling M, Vortkamp A. | 03/23/2019 |
| Activated FGFR3 signaling prevented sclerotic changes of the subchondral bone and subsequent cartilage degeneration. | Activated FGFR3 prevents subchondral bone sclerosis during the development of osteoarthritis in transgenic mice with achondroplasia.
Okura T, Matsushita M, Mishima K, Esaki R, Seki T, Ishiguro N, Kitoh H. | 03/23/2019 |
| Authors showed that in chondrocytes from human (ACH, TD) and mouse Fgfr3Y367C/+ cartilage, the constitutively active FGFR3 perturbed PC length and the sorting and trafficking of intraflagellar transport (IFT) 20 to the PC. | Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.
Martin L, Kaci N, Estibals V, Goudin N, Garfa-Traore M, Benoist-Lasselin C, Dambroise E, Legeai-Mallet L. | 01/5/2019 |
| Study explored the transgenic model expressing mouse Fgfr3 containing the achondroplasia (Ach) mutation G380R under the Col2 promoter (Ach). Survival and growth rate of the Ach mice were reduced compared to WT littermates. Axial skeletal defects and abnormalities of the sternebrae and vertebrae were observed in the Ach mice. | Skeletal Characterization of the Fgfr3 Mouse Model of Achondroplasia Using Micro-CT and MRI Volumetric Imaging.
Shazeeb MS, Cox MK, Gupta A, Tang W, Singh K, Pryce CT, Fogle R, Mu Y, Weber WD, Bangari DS, Ying X, Sabbagh Y., Free PMC Article | 12/1/2018 |
| Accelerated endochondral ossification could contribute to faster healing in Fgfr3(achondroplasia) mice. | Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis.
Osawa Y, Matsushita M, Hasegawa S, Esaki R, Fujio M, Ohkawara B, Ishiguro N, Ohno K, Kitoh H. | 06/16/2018 |