| selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in the peritoneal cavity. | Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity.
Zhang N, Czepielewski RS, Jarjour NN, Erlich EC, Esaulova E, Saunders BT, Grover SP, Cleuren AC, Broze GJ, Edelson BT, Mackman N, Zinselmeyer BH, Randolph GJ., Free PMC Article | 04/18/2020 |
| Mice with the FVL mutation do not have increased spermatogenesis as compared to wildtype mice. | Factor V Leiden is associated with increased sperm count.
van Mens TE, Joensen UN, Bochdanovits Z, Takizawa A, Peter J, Jørgensen N, Szecsi PB, Meijers JCM, Weiler H, Rajpert-De Meyts E, Repping S, Middeldorp S. | 06/30/2018 |
| Platelet-derived FV is a critical mediator of arterial thrombosis that involves platelet activation. | Platelet-Derived Factor V Is a Critical Mediator of Arterial Thrombosis.
Ren M, Li R, Chen N, Pang N, Li Y, Deng X, Wang L, Luo M, Liu Y, Hao H, Liu Y, Sun H, Wu J., Free PMC Article | 05/19/2018 |
| Platelet-derived FV contributes to the control of angiogenesis and is likely associated with thrombin generation in hind limb ischemia model. | Platelet-derived factor V promotes angiogenesis in a mouse hind limb ischemia model.
Yang Y, Xiao L, Chen N, Li Y, Deng X, Wang L, Sun H, Wu J. | 05/20/2017 |
| These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC in the context of endotoxemia and infection | Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.
Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernández JA, Camire RM, Ruf W, Griffin JH, Weiler H., Free PMC Article | 03/5/2016 |
| Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin. | Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D., Free PMC Article | 11/26/2011 |
| The FVL mutation does not influence coagulation activation, lung inflammation or survival in lethal influenza A. | Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenza.
Schouten M, van der Sluijs KF, Roelofs JJ, Levi M, Van't Veer C, van der Poll T. | 04/2/2011 |
| It suggested that there could be a combination of GLA deficiency and FVL or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis. | [Synergistic effect of deficiency in thrombosis-related genes].
Shen YC, Luo BH, Ou BR, Chen AL, Wang XM, Li J. | 09/20/2010 |
| Data suggest that tissue factor and factor V induction by LPS may in part accelerate mesangioproliferative glomerulonephritis through activation of factor X and downstream proinflammatory and procoagulant mechanisms. | Lipopolysaccharide-triggered acute aggravation of mesangioproliferative glomerulonephritis through activation of coagulation in a high IgA strain of ddY mice.
Shimosawa M, Sakamoto K, Tomari Y, Kamikado K, Otsuka H, Liu N, Kitamura H, Uemura K, Nogaki F, Mori N, Muso E, Yoshida H, Ono T. | 01/21/2010 |
| Homozygous Factor V could promote atherosclerosis and fibrin deposition in apolipoprotein E deficient mice. | [Factor V Leiden mutation leads to enhanced atherosclerosis in apolipoprotein E deficient mice].
Shen YC, Lu DF, Wu J, Pan JZ, Zhao CC, Hu DX, Li J. | 01/21/2010 |
| In contrast to humans, pregnancy induced a decrease in APC resistance in wild-type and in FV Leiden mice. | Pregnancy-associated changes in the hemostatic system in wild-type and factor V Leiden mice.
Tchaikovski SN, van Vlijmen BJ, Cleuren AC, Thomassen MC, Tchaikovski V, Tans G, Rosing J. | 01/21/2010 |
| the factor V Leiden mutation is associated with enhanced thrombotic tendency after FeCl3 injury of the femoral artery on a standard fat diet, but not a high fat diet | Factor V Leiden mutation is associated with enhanced arterial thrombotic tendency in lean but not in obese mice.
Nagai N, Lijnen HR, Cleuren AC, Rosendaal FR, Van Hoef B, Hoylaerts MF, Van Vlijmen BJ. | 01/21/2010 |
| Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. | Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.
Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin SR, Weiler H., Free PMC Article | 01/21/2010 |
| FV Leiden allele has no effect in murine colitis and we thus question the importance of activated blood coagulation in the etiology or pathogenesis of inflammatory bowel disease. | Factor V Leiden and the etiology of inflammatory bowel disease.
Spek CA, ten Kate FJ, te Velde AA. | 01/21/2010 |
| The FVL mutation has no effect on the development of secondary tumours of colon cancer in livers of mice. | Colon cancer metastasis in mouse liver is not affected by hypercoagulability due to Factor V Leiden mutation.
Klerk CP, Smorenburg SM, Spek CA, Van Noorden CJ., Free PMC Article | 01/21/2010 |
| observations demonstrate a synergistic interaction between alpha-galactosidase A deficiency and Factor V Leiden toward tissue fibrin deposition; concomitant mutations in these genes may increase the penetrance of vascular thrombotic events in humans | Alpha-galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the factor V Leiden mutation.
Shen Y, Bodary PF, Vargas FB, Homeister JW, Gordon D, Ostenso KA, Shayman JA, Eitzman DT. | 01/21/2010 |
| The source of the FVL leading to accelerated thrombosis appears to be circulating, non-platelet-derived plasma FVL. | Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice.
Eitzman DT, Westrick RJ, Shen Y, Bodary PF, Gu S, Manning SL, Dobies SL, Ginsburg D. | 01/21/2010 |
| FVL has the ability to improve the hemophilia A or B phenotype, but this effect is principally evident at the microcirculation level following a particular vascular injury. | Factor V Leiden improves in vivo hemostasis in murine hemophilia models.
Schlachterman A, Schuettrumpf J, Liu JH, Furlan Freguia C, Toso R, Poncz M, Camire RM, Arruda VR. | 01/21/2010 |
| the murine platelet and plasma FV pools are biosynthetically distinct | The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis.
Sun H, Yang TL, Yang A, Wang X, Ginsburg D. | 01/21/2010 |
| that the murine platelet FV compartment is derived exclusively from primary biosynthesis within cells of marrow origin and an intact platelet FV pool is not required for protection from spontaneous hemorrhage or bleeding following minor trauma | Biosynthetic origin and functional significance of murine platelet factor V.
Yang TL, Pipe SW, Yang A, Ginsburg D. | 01/21/2010 |