| P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis. | P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.
Chen L, Liu Y, Yue S, Wang H, Chen J, Ma W, Xu W, Xu M, Chen Z, Chen X, Zhang L, Liang C., Free PMC Article | 07/18/2024 |
| ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation. | ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
Zheng S, Que X, Wang S, Zhou Q, Xing X, Chen L, Hou C, Ma J, An P, Peng Y, Yao Y, Song Q, Li J, Zhang P, Pei H. | 04/2/2024 |
| The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC. | The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC.
Machtens DA, Bresch IP, Eberhage J, Reubold TF, Eschenburg S., Free PMC Article | 10/8/2022 |
| Micro-ribonucleic acid-23a-3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of nucleotide-binding oligomerization-like receptor family pyrin domain containing 3 inflammatory bodies-caused pyroptosis through negatively regulating NIMA-related kinase 7. | Micro-ribonucleic acid-23a-3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of nucleotide-binding oligomerization-like receptor family pyrin domain containing 3 inflammatory bodies-caused pyroptosis through negatively regulating NIMA-related kinase 7.
Chang H, Chang H, Cheng T, Lee GD, Chen X, Qi K., Free PMC Article | 12/11/2021 |
| Hsa-miR-372-5p regulates the NIMA related kinase 7 and IL-1beta release in NK/T-cell lymphoma. | Hsa-miR-372-5p regulates the NIMA related kinase 7 and IL-1β release in NK/T-cell lymphoma.
Chen Q, Liu S, Zhang K, Yu B, Zhang W, Zhang H, Chen X. | 11/6/2021 |
| Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease. | Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease.
Cai H, Wang P, Zhang B, Dong X., Free PMC Article | 08/21/2021 |
| EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7. | EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
O'Regan L, Barone G, Adib R, Woo CG, Jeong HJ, Richardson EL, Richards MW, Muller PAJ, Collis SJ, Fennell DA, Choi J, Bayliss R, Fry AM., Free PMC Article | 06/26/2021 |
| Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine. | Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
Byrne MJ, Nasir N, Basmadjian C, Bhatia C, Cunnison RF, Carr KH, Mas-Droux C, Yeoh S, Cano C, Bayliss R., Free PMC Article | 12/5/2020 |
| Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. | Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ. | 09/19/2020 |
| NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-kappaB signaling. | NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling.
Chen X, Liu G, Yuan Y, Wu G, Wang S, Yuan L., Free PMC Article | 09/5/2020 |
| Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression. | Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.
Adib R, Montgomery JM, Atherton J, O'Regan L, Richards MW, Straatman KR, Roth D, Straube A, Bayliss R, Moores CA, Fry AM. | 08/15/2020 |
| Aurora A kinase expression was positively correlated with YAP in lung cancer. Aurora A depletion suppresses lung cancer cell colony formation, which could be reversed by YAP ectopic overexpression. | Activation of Aurora A kinase increases YAP stability via blockage of autophagy.
Wang P, Gong Y, Guo T, Li M, Fang L, Yin S, Kamran M, Liu Y, Xu J, Xu L, Peng F, Xue X, Yang M, Hung MC, Lam EW, Gu C, Wang C, Zhan Q, Liu Q., Free PMC Article | 07/11/2020 |
| data suggest that NEK7 bridges adjacent NLRP3 subunits with bipartite interactions to mediate the activation of the NLRP3 inflammasome | Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H., Free PMC Article | 02/8/2020 |
| The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis. | The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.
Eisa NH, Jilani Y, Kainth K, Redd P, Lu S, Bougrine O, Abdul Sater H, Patwardhan CA, Shull A, Shi H, Liu K, Elsherbiny NM, Eissa LA, El-Shishtawy MM, Horuzsko A, Bollag R, Maihle N, Roig J, Korkaya H, Cowell JK, Chadli A., Free PMC Article | 10/19/2019 |
| Results demonstrate that NEK7 is involved in the timely regulation of G1 progression, S-phase entry, and procentriole formation. | NEK7 is required for G1 progression and procentriole formation.
Gupta A, Tsuchiya Y, Ohta M, Shiratsuchi G, Kitagawa D., Free PMC Article | 11/18/2017 |
| Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis. | A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.
Cullati SN, Kabeche L, Kettenbach AN, Gerber SA., Free PMC Article | 09/30/2017 |
| TRF1 phosphorylation by Nek7 favors the binding of shelterin protein TIN2 and disfavors E3 ligase Fbx4 interaction, thus preventing TRF1 ubiquitination and proteasome degradation to maintain telomere integrity. | Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.
Tan R, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X, Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B, Lan L., Free PMC Article | 09/9/2017 |
| Studies indicate that NIMA related kinase 7 (NEK7) targets at NLRP3 protein and involves in the activation of NLRP3 inflammasome. | NEK7: a novel promising therapy target for NLRP3-related inflammatory diseases.
Xu J, Lu L, Li L. | 03/4/2017 |
| Study highlights for the first time the possible role of Nek7 in HCC progression. Nek7 would be a useful biomarker that early predicts HCC patients at higher risk of poor prognosis. | Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular carcinoma cell proliferation in vitro and in vivo.
Zhou L, Wang Z, Xu X, Wan Y, Qu K, Fan H, Chen Q, Sun X, Liu C., Free PMC Article | 03/4/2017 |
| NEK7 serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division. | NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, Su L, Pratt D, Bu CH, Hildebrand S, Lyon S, Scott L, Quan J, Sun Q, Russell J, Arnett S, Jurek P, Chen D, Kravchenko VV, Mathison JC, Moresco EM, Monson NL, Ulevitch RJ, Beutler B., Free PMC Article | 07/16/2016 |
| The C-terminal domain of Nek9 activates Nek7 through promoting back-to-back dimerization. | Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.
Haq T, Richards MW, Burgess SG, Gallego P, Yeoh S, O'Regan L, Reverter D, Roig J, Fry AM, Bayliss R., Free PMC Article | 05/21/2016 |
| Results show that NEK7 was directly regulated by WHSC1 through H3K36me2 and its knockdown significantly reduced cell-cycle progression, indicating that NEK7 is a key player in the molecular pathway regulated by WHSC1. | WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck.
Saloura V, Cho HS, Kiyotani K, Alachkar H, Zuo Z, Nakakido M, Tsunoda T, Seiwert T, Lingen M, Licht J, Nakamura Y, Hamamoto R. | 04/2/2016 |
| RGS2 or Nek7 depletion or even overexpression of wild-type or kinase-dead Nek7, reduced gamma-tubulin from the mitotic spindle poles. | Human Nek7-interactor RGS2 is required for mitotic spindle organization.
de Souza EE, Hehnly H, Perez AM, Meirelles GV, Smetana JH, Doxsey S, Kobarg J., Free PMC Article | 12/5/2015 |
| Nek7 increased Ser/Thr phosphorylation of Anks3 primarily within ankyrin domain.Interaction with Anks3 led to cytoplasmic retention and nuclear exclusion of Nek7. | Anks3 alters the sub-cellular localization of the Nek7 kinase.
Ramachandran H, Engel C, Müller B, Dengjel J, Walz G, Yakulov TA. | 11/14/2015 |
| Nek7, was significantly associated with certain clinicopathologic indices in gallbladder carcinoma | The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival.
Wang R, Song Y, Xu X, Wu Q, Liu C. | 02/1/2014 |