| Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking. | Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking.
Mulholland PJ, Padula AE, Wilhelm LJ, Park B, Grant KA, Ferguson BM, Cervera-Juanes R., Free PMC Article | 12/1/2023 |
| Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis. | Endothelial K(Ca)3.1 and K(Ca)2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis.
Li JJ, Zhao XY, Wang Y, Xu R, Di XH, Zhang Y, Yang H, Han MZ, Bai RY, Xie L, Pang ZD, Zhang X, Zhang J, Du XJ, Deng XL, Zhang Y, Xie W. | 05/1/2023 |
| Erectile Dysfunction and Altered Contribution of KCa1.1 and KCa2.3 Channels in the Penile Tissue of Type-2 Diabetic db/db Mice. | Erectile Dysfunction and Altered Contribution of KCa1.1 and KCa2.3 Channels in the Penile Tissue of Type-2 Diabetic db/db Mice.
Comerma-Steffensen S, Prat-Duran J, Mogensen S, Fais R, Pinilla E, Simonsen U. | 05/7/2022 |
| Bioinformatics identification and pharmacological validation of Kcnn3/KCa2 channels as a mediator of negative affective behaviors and excessive alcohol drinking in mice. | Bioinformatics identification and pharmacological validation of Kcnn3/K(Ca)2 channels as a mediator of negative affective behaviors and excessive alcohol drinking in mice.
Padula AE, Rinker JA, Lopez MF, Mulligan MK, Williams RW, Becker HC, Mulholland PJ., Free PMC Article | 07/10/2021 |
| AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice. | AMPK upregulates K(Ca)2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice.
Pang ZD, Wang Y, Song Z, She G, Ma XZ, Sun X, Wu W, Lai BC, Zhang J, Zhang Y, Du XJ, Shyy JYJ, Deng XL. | 04/17/2021 |
| Properties of SK3 channel-expressing PDGFRalpha (+) cells in the rodent urinary bladder | Properties of SK3 channel-expressing PDGFRα (+) cells in the rodent urinary bladder.
Hayashi T, Hashitani H, Takeya M, Uemura KI, Nakamura KI, Igawa T. | 01/11/2020 |
| Caveolae provide a key microdomain in renal collecting duct cells for coupling of TRPV4 with SK3, IK1, and BK that directly contributes to TRPV4-mediated Ca(2+) signaling in these domains. | Caveolae facilitate TRPV4-mediated Ca(2+) signaling and the hierarchical activation of Ca(2+)-activated K(+) channels in K(+)-secreting renal collecting duct cells.
Li Y, Hu H, O'Neil RG., Free PMC Article | 09/21/2019 |
| These findings demonstrate how Ca(2+) influx through TRPV4 channels can activate SK channels in PDGFRalpha(+) cells and prevent bladder overactivity during filling. | Premature contractions of the bladder are suppressed by interactions between TRPV4 and SK3 channels in murine detrusor PDGFRα(+) cells.
Lee H, Koh BH, Peri LE, Corrigan RD, Lee HT, George NE, Bhetwal BP, Xie Y, Perrino BA, Chai TC, Sanders KM, Koh SD., Free PMC Article | 07/20/2019 |
| the present study shows that KCa2.3 channels are located in the apical plasma membrane of endothelial cells, and occasionally at inter-endothelial junctions of the corpus cavernosum. We found that down-regulation of these channels increases norepinephrine contraction in corpus cavernosum strips, and it seems associated with erectile dysfunction. | Down-regulation of K(Ca)2.3 channels causes erectile dysfunction in mice.
Comerma-Steffensen S, Kun A, Hedegaard ER, Mogensen S, Aalkjaer C, Köhler R, Mønster Christensen B, Simonsen U., Free PMC Article | 12/22/2018 |
| Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT) neuronal excitability. | Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels.
Sargin D, Oliver DK, Lambe EK., Free PMC Article | 12/16/2017 |
| These results identify SK3 as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY neural activities and animals' feeding behavior and energy metabolism. | A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism.
He Y, Shu G, Yang Y, Xu P, Xia Y, Wang C, Saito K, Hinton A Jr, Yan X, Liu C, Wu Q, Tong Q, Xu Y., Free PMC Article | 11/25/2017 |
| Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells. | Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel in kidney collecting duct cells.
Li Y, Hu H, Tian JB, Zhu MX, O'Neil RG., Free PMC Article | 08/12/2017 |
| SK3 signaling microdomain modulates endothelial Ca(2+) dynamics, vascular tone, and blood pressure. SK3 knockout mice are hypertensive. | Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure.
Yap FC, Weber DS, Taylor MS, Townsley MI, Comer BS, Maylie J, Adelman JP, Lin MT., Free PMC Article | 07/1/2017 |
| The data of this study implicated the family of KCNN genes in alcohol, nicotine, and drug addiction, and identify KCNN3 as a mediator of voluntary and excessive alcohol consumption | KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction.
Padula AE, Griffin WC 3rd, Lopez MF, Nimitvilai S, Cannady R, McGuier NS, Chesler EJ, Miles MF, Williams RW, Randall PK, Woodward JJ, Becker HC, Mulholland PJ., Free PMC Article | 03/12/2016 |
| ovariectomy leads to a reduction in endothelial SK3 channel activity thereby reducing the SK3 contribution to endothelium-dependent hyperpolarization vasorelaxation. | Ovariectomy-induced reductions in endothelial SK3 channel activity and endothelium-dependent vasorelaxation in murine mesenteric arteries.
Yap FC, Taylor MS, Lin MT., Free PMC Article | 12/12/2015 |
| Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias. | Down-regulation of the small conductance calcium-activated potassium channels in diabetic mouse atria.
Yi F, Ling TY, Lu T, Wang XL, Li J, Claycomb WC, Shen WK, Lee HC., Free PMC Article | 05/30/2015 |
| Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels | Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels.
Wandall-Frostholm C, Skaarup LM, Sadda V, Nielsen G, Hedegaard ER, Mogensen S, Köhler R, Simonsen U., Free PMC Article | 02/28/2015 |
| SK3 channel modulates placental vascular development and fetal health by altering VEGF signaling. | The SK3 channel promotes placental vascularization by enhancing secretion of angiogenic factors.
Rada CC, Murray G, England SK., Free PMC Article | 02/28/2015 |
| SK3 is functionally expressed in the distal nephron and collecting ducts where induction of TRPV4-mediated Ca2+ influx activates the channel. | Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4.
Berrout J, Mamenko M, Zaika OL, Chen L, Zhang W, Pochynyuk O, O'Neil RG., Free PMC Article | 01/24/2015 |
| Reduced SK3 expression attenuates endometrial cell migration and is associated with unsuccessful pregnancy outcomes. | Small-conductance, calcium-activated potassium channel 3 (SK3) is a modulator of endometrial remodeling during endometrial growth.
Lu YC, Yang J, Ding GL, Shi S, Zhang D, Jin L, Pan JX, Lin XH, Zhu YM, Sheng JZ, Huang HF. | 01/24/2015 |
| SK3 channel contributes importantly towards atrial action potential repolarization. | Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.
Zhang XD, Timofeyev V, Li N, Myers RE, Zhang DM, Singapuri A, Lau VC, Bond CT, Adelman J, Lieu DK, Chiamvimonvat N., Free PMC Article | 10/4/2014 |
| Overexpression of the SK3 channel causes an increased risk of sudden death associated with bradyarrhythmias and heart block, possibly due to atrioventricular nodal dysfunction. | Overexpression of KCNN3 results in sudden cardiac death.
Mahida S, Mills RW, Tucker NR, Simonson B, Macri V, Lemoine MD, Das S, Milan DJ, Ellinor PT., Free PMC Article | 10/4/2014 |
| SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats | Expression of postsynaptic Ca2+-activated K+ (SK) channels at C-bouton synapses in mammalian lumbar -motoneurons.
Deardorff AS, Romer SH, Deng Z, Bullinger KL, Nardelli P, Cope TC, Fyffe RE., Free PMC Article | 08/10/2013 |
| SK3-mediated [Ca(2+)]i elevation and membrane potential hyperpolarization in trophectoderm cells are important for blastocyst hatching. | Small-conductance calcium-activated K(+) channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration.
Lu YC, Ding GL, Yang J, Zhang YL, Shi S, Zhang RJ, Zhang D, Pan JX, Sheng JZ, Huang HF. | 02/2/2013 |
| The results established that the SK3 channel contributes to both maternal and fetal outcomes during pregnancy. | Overexpression of the SK3 channel alters vascular remodeling during pregnancy, leading to fetal demise.
Rada CC, Pierce SL, Nuno DW, Zimmerman K, Lamping KG, Bowdler NC, Weiss RM, England SK., Free PMC Article | 01/12/2013 |