| NR2F1 shapes mitochondria in the mouse brain, providing new insights into Bosch-Boonstra-Schaaf optic atrophy syndrome. | NR2F1 shapes mitochondria in the mouse brain, providing new insights into Bosch-Boonstra-Schaaf optic atrophy syndrome.
Bonzano S, Dallorto E, Molineris I, Michelon F, Crisci I, Gambarotta G, Neri F, Oliviero S, Beckervordersandforth R, Lie DC, Peretto P, Bovetti S, Studer M, De Marchis S., Free PMC Article | 07/3/2023 |
| Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver. | Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver.
Cholico GN, Nault R, Zacharewski TR., Free PMC Article | 03/12/2022 |
| COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex. | COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex.
Del Pino I, Tocco C, Magrinelli E, Marcantoni A, Ferraguto C, Tomagra G, Bertacchi M, Alfano C, Leinekugel X, Frick A, Studer M. | 12/4/2021 |
| Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity. | Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.
Chen CA, Wang W, Pedersen SE, Raman A, Seymour ML, Ruiz FR, Xia A, van der Heijden ME, Wang L, Yin J, Lopez J, Rech ME, Lewis RA, Wu SM, Liu Z, Pereira FA, Pautler RG, Zoghbi HY, Schaaf CP., Free PMC Article | 07/10/2021 |
| NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients. | NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients.
Bertacchi M, Romano AL, Loubat A, Tran Mau-Them F, Willems M, Faivre L, Khau van Kien P, Perrin L, Devillard F, Sorlin A, Kuentz P, Philippe C, Garde A, Neri F, Di Giaimo R, Oliviero S, Cappello S, D'Incerti L, Frassoni C, Studer M., Free PMC Article | 04/13/2021 |
| Mouse Nr2f1 haploinsufficiency results in model of Bosch-Boonstra-Schaaf optic atrophy. | Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome.
Bertacchi M, Gruart A, Kaimakis P, Allet C, Serra L, Giacobini P, Delgado-García JM, Bovolenta P, Studer M., Free PMC Article | 05/9/2020 |
| Loss of Nr2f1 in mouse cortex leads to increased locomotor activity but less anxiety. | Hyperactive and anxiolytic-like behaviors result from loss of COUP-TFI/Nr2f1 in the mouse cortex.
Contesse T, Ayrault M, Mantegazza M, Studer M, Deschaux O. | 01/18/2020 |
| COUP-TFI as a central regulator of the neuron-astroglia cell fate decision and a key modulator during neuroinflammation in the adult hippocampus. | Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo.
Bonzano S, Crisci I, Podlesny-Drabiniok A, Rolando C, Krezel W, Studer M, De Marchis S. | 11/9/2019 |
| These data support a translational control of COUP-TFI gradient expression by FGF8 via miR-21 and contribute to our understanding of how regionalized expression is established during neocortical area mapping. | The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.
Terrigno M, Bertacchi M, Pandolfini L, Baumgart M, Calvello M, Cellerino A, Studer M, Cremisi F., Free PMC Article | 09/21/2019 |
| These results indicate that COUP-TF1 plays an important role in modulating the timing and magnitude of T3-stimulated gene expression required for normal corticogenesis. | COUP-TF1 Modulates Thyroid Hormone Action in an Embryonic Stem-Cell Model of Cortical Pyramidal Neuronal Differentiation.
Teng X, Liu YY, Teng W, Brent GA., Free PMC Article | 02/2/2019 |
| COUP-TFI expression is required for functional organization of the hippocampal septo-temporal longitudinal axis | Gradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal Axis.
Flore G, Di Ruberto G, Parisot J, Sannino S, Russo F, Illingworth EA, Studer M, De Leonibus E. | 03/10/2018 |
| These data identify silencer elements of the Nr2f1-A830082K12Rik gene pair as new candidate loci for Waardenburg syndrome type 4. | Upregulation of the Nr2f1-A830082K12Rik gene pair in murine neural crest cells results in a complex phenotype reminiscent of Waardenburg syndrome type 4.
Bergeron KF, Nguyen CM, Cardinal T, Charrier B, Silversides DW, Pilon N., Free PMC Article | 12/9/2017 |
| Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons | Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons.
Hu JS, Vogt D, Lindtner S, Sandberg M, Silberberg SN, Rubenstein JLR., Free PMC Article | 10/7/2017 |
| COUP-TFI is required predominantly in Dentate gyrus progenitors for modulating expression of the Cxcr4 receptor during granule cell neurogenesis and migration. | COUP-TFI mitotically regulates production and migration of dentate granule cells and modulates hippocampal Cxcr4 expression.
Parisot J, Flore G, Bertacchi M, Studer M. | 09/23/2017 |
| Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb. | Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb.
Zhou X, Liu F, Tian M, Xu Z, Liang Q, Wang C, Li J, Liu Z, Tang K, He M, Yang Z. | 07/25/2015 |
| Findings provide evidence that Sp8 and another transcription factor, COUP-TF1, mutually repress each other's cortical neuroepithelial expression along the anterior-posterior and dorsoventral axes | Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.
Borello U, Madhavan M, Vilinsky I, Faedo A, Pierani A, Rubenstein J, Campbell K., Free PMC Article | 12/20/2014 |
| a novel tissue-dependent coregulatory network for NR2F1, miR-140, and Klf9 in the inner ear | A coregulatory network of NR2F1 and microRNA-140.
Chiang DY, Cuthbertson DW, Ruiz FR, Li N, Pereira FA., Free PMC Article | 10/4/2014 |
| odour deprivation, which is known to downregulate tyrosine hydroxylase expression in the olfactory bulb, also downregulates COUP-TFI in dopaminergic cells, indicating a correlation between tyrosine hydroxylase- and COUP-TFI-activity-dependent action. | COUP-TFI controls activity-dependent tyrosine hydroxylase expression in adult dopaminergic olfactory bulb interneurons.
Bovetti S, Bonzano S, Garzotto D, Giannelli SG, Iannielli A, Armentano M, Studer M, De Marchis S. | 02/15/2014 |
| CoupTFI collaborates with retinoic acid signaling to regulate both cortical ventricular zone progenitor cell behavior and cortical neurogenesis | CoupTFI interacts with retinoic acid signaling during cortical development.
Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ., Free PMC Article | 12/7/2013 |
| COUP-TFI and related NRs such as the COUPTFs and PNR can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates COUP-TFII-mediated repression of the RARb2 gene. | A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.
Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM, Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM., Free PMC Articles: PMC3834829, PMC3834829 | 09/24/2013 |
| Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI, COUP-TFII, EAR2 and TLX requires a F/YSXXLXXL/Y motif. NSD1 interaction with liganded NRs is mediated by an overlapping LXXLL motif. | A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.
Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM, Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM., Free PMC Articles: PMC3834829, PMC3834829 | 09/24/2013 |
| Our data suggest that the non-protein coding locus Mcs1a regulates Nr2f1, which is a candidate modifier of differentiation, proliferation, and mammary cancer risk. | The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation.
Smits BM, Haag JD, Rissman AI, Sharma D, Tran A, Schoenborn AA, Baird RC, Peiffer DS, Leinweber DQ, Muelbl MJ, Meilahn AL, Eichelberg MR, Leng N, Kendziorski C, John MC, Powers PA, Alexander CM, Gould MN., Free PMC Article | 09/14/2013 |
| study extends the pool of recognized putative AR targets and identifies a negatively regulated target of AR - COUP-TF1 - which could possibly play a role in human prostate cancer | Genome-wide analysis of androgen receptor targets reveals COUP-TF1 as a novel player in human prostate cancer.
Perets R, Kaplan T, Stein I, Hidas G, Tayeb S, Avraham E, Ben-Neriah Y, Simon I, Pikarsky E., Free PMC Article | 06/15/2013 |
| Exogenous expression of COUP-TFI in AS cells, in a dose-dependent fashion, leads to growth inhibition. | Role of COUP-TFI during retinoic acid-induced differentiation of P19 cells to endodermal cells.
Pickens BS, Teets BW, Soprano KJ, Soprano DR., Free PMC Article | 05/25/2013 |
| Data demonstrate that COUP-TFI modulates late-born neuron migration and favours proper differentiation of callosal projection neurons by finely regulating Rnd2 expression levels. | COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression.
Alfano C, Viola L, Heng JI, Pirozzi M, Clarkson M, Flore G, De Maio A, Schedl A, Guillemot F, Studer M. | 12/31/2011 |